Effect of ascorbic acid administration on erythrocyte osmotic fragility of pigs transported by road during the hot-dry season

Asala, Olayinka; Ayo, Joseph Olusegun; Rekwot, P.I.; Minka, Ndazo Salka; Omoniwa, D. O.; Adenkola, A. Y.

doi:10.1007/s11259-011-9469-7

Cited by 20 publications

(17 citation statements)

References 29 publications

(35 reference statements)

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“…Similar effects of VE and AA on the erythrocytes have been reported in humans, suffering from different diseases or subjected to strenuous exercise [8,41,39], and in livestock, including poultry, subjected to diverse pharmacological and stressful conditions [12,14,15,19,46]. Of recent, the ameliorating effect of AA on the erythrocytes was shown in transported pigs [11,13] andgoats [24]. The result obtained in the present study on VE and AA clearly indicated the role of the antioxidant vitamins in maintaining erythrocyte membrane integrity and, consequently, decreasing the degree of haemolysis in transported quails.…”

Section: Citationsupporting

confidence: 60%

“…This mechanism is induced by the action of catecholamines on adrenergic receptors, located in the splenic capsule and partly attributed to a reduction in the plasma volume [8]. The higher (P<0.05) Hb concentration and EOF values obtained immediately, and 3and 7 days after transportation in the control quails as compared to VE and AA quails, indicates erythrocyte destruction due to the adverse effects of road transportation stress factors.Such stress factors were mainly handling, crating, vehicle motion and vibration, noise from the engine or moving vehicle, incremental micro-environmental conditions, travel sickness and novelty to the environment [12,13,24]. The stress factors in a complex way overtax the animal control systems and induce oxidative stress [1,12].…”

Section: Citationmentioning

confidence: 99%

“…The EOF may be employed as a biomarker and additional diagnostic tool for the assessment of transport-induce oxidative stress in quails. [7,10].The use of EOF as a biomarker of road transport-induced stress in livestock is a new field of study that may add to the arsenals of tests, currently used in the diagnosis of stress due to road transportation [11][12][13]. Body temperature measurement is an important method of evaluation of physiological status.…”

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Effects of Antioxidants Vitamin E and C on ErythrocyteFragility, HaemoglobinIndex and Colonic Temperature of Transported Japanese Quails (Coturnixcoturnix japonica)

Minka¹

2013

J Veterinar Sci Technolo

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The present study investigated the effects of antioxidants Vitamin E (VE) and C (ascorbic acid, AA) on erythrocytes osmotic fragility (EOF), haemoglobin index (HI), colonic temperature (CT) and recovery times of transported Japanese quails during the hot-dry conditions. Two hundred male Japanese quails were used. The birds were randomly and equally divided into four groups: VE and AA groups, administered with 0.5 mg/kg and 200 mg/ kg body weight of VE and AA, respectively, control transported group (control group), administered with 0.5 ml of sterile water, and sedentary non-transported group (S). One hour after the administration of the antioxidants, the birds were transported by road for 2 h. The EOF, HI and CT were recorded before transportation, immediately after transportation (0) and on 3 rd and 7 th day of post-transportation period. The results showed that transportation induced hyperthermia, increased EOF and hypochromic erythrocytes in the quails, the effects of which were mitigated by antioxidants VE and AA. Base-line values for EOF were returned to normal in the control, AA and VE quails on days 7, 3 and 0, respectively post-transportation. The findings showed that recovery time after transportation in quails should be 7 days; but the duration may be reduced to 3 days if treated with AA or eliminated completely if the quails are treated with VE before transportation. The ameliorating effect was more pronounced in quails administered with antioxidant VE. The EOF may be employed as a biomarker and additional diagnostic tool for the assessment of transport-induce oxidative stress in quails. [7,10].The use of EOF as a biomarker of road transport-induced stress in livestock is a new field of study that may add to the arsenals of tests, currently used in the diagnosis of stress due to road transportation [11][12][13]. Body temperature measurement is an important method of evaluation of physiological status. It is also an ideal indicator for the assessment of stress and adaptability of livestock, including poultry, to various environmental stress factors [14][15][16]. Effects of Antioxidants Vitamin E and C on ErythrocyteFragilitySeveral stress factors have been reported to decrease the level of body antioxidants, vitamin E (VE) and vitamin C, otherwise known as ascorbic acid (AA); resulting in increases in the body requirements in these vitamins [14,[17][18][19]. The administration of the vitamins exerts ameliorating effects which are well manifested; when the body AA and VE are either overwhelmed or exhausted as a result of increased ROS generation by stress factors that overtax the animal control systems [18,20]. Therefore, a decrease in the concentration of antioxidant vitamins causes an increase in lipid peroxidation in the plasma and tissues, leading to damage of cell membranes [21,22]. Previous reports have revealed the beneficial effects of supplementation of VE and AA on birds and animals, subjected to various oxidative stress factors [12,16,18,22].Several studies have evaluated the respon...

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Section: Citationsupporting

confidence: 60%

Section: Citationmentioning

confidence: 99%

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confidence: 99%

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Effects of Antioxidants Vitamin E and C on ErythrocyteFragility, HaemoglobinIndex and Colonic Temperature of Transported Japanese Quails (Coturnixcoturnix japonica)

Minka¹

2013

J Veterinar Sci Technolo

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“…Erythrocyte osmotic fragility (EOF) is an important biomarker of oxidative stress (Minka & Ayo 2010b;Asala et al 2011;Olaifa et al 2012). The EOF test is used to assess the stability of erythrocytes in hypotonic solutions in birds (Minka & Ayo 2010b.…”

Section: Introductionmentioning

confidence: 99%

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Sinkalu

Ayo

Abimbola

et al. 2014

Journal of Applied Animal Research

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Experiments were conducted with the aim of determining effects of melatonin on fluctuations in cloacal temperature (CT) and erythrocyte osmotic fragility (EOF) of layer hens. The CT of 14 melatonin-treated and 12 control laying hens were taken for 2 days, 1 week apart, at 06:00 h, 14:00 h and 18:00 h, using a standard digital thermometer inserted into the cloaca. The control birds were given water only, while the treated layers were individually administered at 18:00 h with melatonin orally. On day 12 of the administration, venous blood samples were collected from the layer hens to determine EOF. The overall mean CT values in melatonin-treated and control birds were 41.0 ± 0.05°C and 40.9 ± 0.04°C, respectively (P < 0.05). CT of the melatonin-treated group was lowest at 06:00 h (40.9 ± 0.10°C), but highest at 18:00 h (41.2 ± 0.05°C; P < 0.05). At 0.1%, EOF of 62.01 ± 3.75% obtained in melatonin-treated layer hens was lower (P < 0.001) than the corresponding value of 73.86 ± 2.59%, recorded in control layer hens. In conclusion, melatonin administration to layer hens sustained thermal homeostasis and decreased EOF in layer hens during the hot-dry season.

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“…Effect of treatments on erythrocyte osmotic fragility in wistar rats exposed to noise stress Erythrocyte osmotic fragility (EOF) which measures the resistance of erythrocyte to intracellular pressure is known to be a biomarker of oxidative stress or lipid peroxidation [34].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress

Ao¹,

Ao²,

So³

et al. 2017

Insights Biomed

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Effect of ascorbic acid administration on erythrocyte osmotic fragility of pigs transported by road during the hot-dry season

Cited by 20 publications

References 29 publications

Effects of Antioxidants Vitamin E and C on ErythrocyteFragility, HaemoglobinIndex and Colonic Temperature of Transported Japanese Quails (Coturnixcoturnix japonica)

Effects of Antioxidants Vitamin E and C on ErythrocyteFragility, HaemoglobinIndex and Colonic Temperature of Transported Japanese Quails (Coturnixcoturnix japonica)

Effects of melatonin on cloacal temperature and erythrocyte osmotic fragility in layer hens during the hot-dry season

Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress

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