Effect of Ascorbic Acid 2-Sulfate on the Faecal Excretion of Exogenous Cholesterol in the Rat

Effects of Ascorbic Acid and its 2-Sulfate on Rabbit Aortic Intimal Thickening

“…Cholesterol has been shown to be sulfated in vivo to form the more watersoluble cholesterol sulfate which is then excreted [36]. However, this process has been reported to be not very significant [17,18] and it does not seem likely that this is the mechanism of the reduction in intimal thickening especially when high dietary doses of cholesterol are being used. Thus, L-ascorbic acid and L-ascorbic acid 2-sulfate probably affect the lipid deposition process in some way and it is conceivable that it is related to biological sulfation other than cholesterol sulfate formation.…”

“…L-Ascorbic acid 2-sulfate has been demon strated to be an excellent sulfating agent of alcohols under oxidizing or transesterification conditions [12], Recently. L-ascorbic acid 2-sulfate has been shown to be a naturally occurring compound in human urine [2], bile [17] and in rat liver [27], L-ascorbic acid 2-sulfate has been shown to in fluence sulfation in cultured fibroblasts [3], in embryonic brine shrimp cysts [15] and in liver and kidney slices [6], L-Ascorbic acid effects the hepatic metabolism of cholesterol [14,18,30], and L-ascorbic acid 2-sulfate has been shown to effect the sulfation of cholesterol in vivo [36],…”

Effect of L-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs.

“…Verlangieri and Mumma (16) reported an increased excretion of cholesterol sulfate into the feces of rats that received AAS by an intracardial injection . Hornig et al (17), however, reported that these effects were not observed in animals that were intravenously injected AAS and, 5 hr after the injection of AAS , [4-14C]cholesterol. Since most of the AAS intravenously injected was excreted within 5 hr into the urine (18), the effects of AAS on the excretion of cholesterol sulfate should be studied further.…”