Effect of As2O3 and Ginsenoside Rg3 on Inhibiting Angiogenesis in Rabbit Liver VX2 Tumor

Abstract

Liver cancer is an aggressive disease with a poor outcome. Here, we implicate the roles of arsenic trioxide (As 2 O 3 ) and Ginsenoside Rg3 (GRg3) in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF). Rabbits VX2 liver cancer models were established, then 24 rabbits were randomly divided into 3 groups with the same number (As 2 O 3 , GRg3 and control). Liver function and the levels of VEGF and CD31 were assessed. The tumor weight and levels of VEGF and CD31 in As 2 O 3 and GRg3-treated rabbits were lower than those in controls, while no significant differences between As 2 O 3 and GRg3 groups. There was no significant difference in the liver function among the groups. In conclusion, our findings implicate decreases in the tumor weight and the levels of VEGF and CD31 in the rabbits VX2 liver cancer induced by As 2 O 3 and GRg3, while no significant differences between As 2 O 3 and GRg3. GRg3 might be much more convenient than As 2 O 3 in clinical application.