Effect of Artichoke (<i>cynara scolymus</i>) on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity

Salem, Maryem Ben; Affes, Hanen; Dhouibi, Raouia; Turki, Mouna; Hammami, S.; Ayedi, Fatma; Sahnoun, Zouheir; Zeghal, Khaled Mounir; Ksouda, Kamilia

doi:10.1080/13813455.2019.1670213

Cited by 15 publications

(17 citation statements)

References 47 publications

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“…Then, deciphering how ALE may influence primary human adipocyte behavior and lipid metabolism contribute to the understanding of its health benefits. In high-fat diet rodent models, ALE limits body and organ weight gain by restraining serum total cholesterol and triglycerides and cell hypertrophy [ 32 ]. Chlorogenic acid (CGA) may account for this effect, as it can reduce body weight and fat deposition in a monosodium glutamate (MSG)-induced obesity mouse model [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Wauquier¹,

Boutin-Wittrant²,

Viret

et al. 2021

Nutrients

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The aging of our population is accompanied by an increased prevalence of chronic diseases. Among those, liver, joint and adipose tissue-related pathologies have a major socio-economic impact. They share common origins as they result from a dysregulation of the inflammatory and metabolic status. Plant-derived nutrients and especially polyphenols, exert a large range of beneficial effects in the prevention of chronic diseases but require clinically validated approaches for optimized care management. In this study, we designed an innovative clinical approach considering the metabolites produced by the digestive tract following the ingestion of an artichoke leaf extract. Human serum, enriched with metabolites deriving from the extract, was collected and incubated with human hepatocytes, human primary chondrocytes and adipocytes to determine the biological activity of the extract. Changes in cellular behavior demonstrated that the artichoke leaf extract protects hepatocytes from lipotoxic stress, prevents adipocytes differentiation and hyperplasia, and exerts chondroprotective properties in an inflammatory context. These data validate the beneficial health properties of an artichoke leaf extract at the clinical level and provide both insights and further evidence that plant-derived nutrients and especially polyphenols from artichoke may represent a relevant alternative for nutritional strategies addressing chronic disease issues.

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Section: Discussionmentioning

confidence: 99%

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Wauquier¹,

Boutin-Wittrant²,

Viret

et al. 2021

Nutrients

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“…Artichokes have several healthy properties including antioxidant activity, lipid and cholesterol reduction, and a decrease in postprandial glycemic and insulin response [ 58 , 59 , 60 ]. Components of artichokes which have an effect are caffeic acid derivatives, flavonoids, such as luteolin, cynaroside, scolymoside, and cynarotrioside and sesquiterpenic lactones; artichokes decrease production of cholesterol and endogenous triglycerides and increase their excretion by bile production [ 21 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Production of Vegetables and Artichokes Is Associated with Lower Cardiovascular Mortality: An Ecological Study

Arnedo-Pena

Puig-Barberà

Bellido-Blasco

et al. 2020

IJERPH

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Mortality due to cardiovascular disease (CVD), including cerebrovascular disease (CED) and ischaemic heart disease (IHD), was considerably different in eight municipalities of the province of Castellón, Community of Valencia (Spain) during the period of 1991–2011. In addition, these villages showed differences in agricultural practices and production. Since high vegetable consumption has been linked to decreased all-cause, CVD, and CED mortalities, we hypothesized that the diversity in vegetable and artichoke production, used as proxies for their consumption, could be associated with the diversity of mortality rates. In order to test our hypothesis, we estimated the smoothed standardized mortality ratios (SMRs) of CVD, CED, and IHD mortalities and a directed, age-adjusted mortality rate (AMR). We used a multilevel linear regression analysis to account for the ecological nature of our study. After adjustment, the CVD and CED SMRs were inversely associated with vegetable and artichoke production, with a reduction in SMRs for CVD: −0.19 (95% Confidence Interval [CI] −0.31 to −0.07) and −0.42 (95% CI −0.70 to −0.15) per hectare/103 inhabitants, respectively. The SMRs for CED also decreased: −0.68 (95% CI −1.61 to −0.19) and −1.47 (95% CI −2.57 to −0.36) per hectare/103 inhabitants, respectively. The SMRs for IHD were not associated with vegetal and artichoke production. When the directed AMR was used, CED mortality was consistent with the previous results, whereas the CVD mortality association was lost. Our results indicate that vegetable and artichoke production may act as protective factors of CED and CVD mortalities.

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“…As a result of supplementation of rats with ALE (200 mg/kg and 400 mg/kg), there was an improvement in the lipidic profile due to the decrease in TC, TG, and LDL-c levels and increase in HDL-c levels. In addition, ALE supplementation also reduced the cardiac markers and increased the antioxidant enzyme SOD, GPx, and GSH activities [159]. The effect of artichoke extracts on liver phosphatide phosphohydrolase and lipid profile in hyperlipidemic rats was also evaluated by Heidarian and colleagues.…”

Section: Hypolipidemic Activitymentioning

confidence: 98%

“…Ben Salem and collaborators demonstrated the effect of ALE on the lipidic profile, cardiac markers, and antioxidant levels in obese rats [159]. As a result of supplementation of rats with ALE (200 mg/kg and 400 mg/kg), there was an improvement in the lipidic profile due to the decrease in TC, TG, and LDL-c levels and increase in HDL-c levels.…”

Section: Hypolipidemic Activitymentioning

confidence: 98%

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Silva

Jacinto

Coutinho

2022

Foods

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Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.

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Effect of Artichoke (cynara scolymus) on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity

Cited by 15 publications

References 47 publications

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Production of Vegetables and Artichokes Is Associated with Lower Cardiovascular Mortality: An Ecological Study

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

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