Effect of Artemisia annua on kidney in gentamicin-induced nephrotoxicity in mice through regulation of the COX-2, NF-κB pathway

Althobaiti, Saed A.; Almalki, Daklallah A.; Qahl, Safa H.; Elsigar, Layaly; Gurafi, Lobna M.A.; Kanani, Zeinab; Nasir, Omaima

doi:10.1016/j.jksus.2023.102813

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Numerous herbs exhibit antioxidant benefits since they contain great concentrations of bioactive components, including carotenoids and polyphenols [ 49 ]. Examples of these antioxidant-rich herbs that have recently proven to exert a protective impact in kidney injury brought on by gentamicin include Cistanche deserticola L., Hedyotis aspera L., and Artemisia annua L. [ 50 , 51 , 52 ]. As already stated, a plant with an increased quantity of bioactive constituents that possess antioxidant qualities is Sorbus aucuparia L. The components from Sorbus aucuparia L. berries might attenuate the gentamicin stress caused to renal tissue, a possible application of this plant for which little research has been conducted.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

Aurori,

Niculae,

Hanganu

et al. 2024

Plants

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Considering that Sorbus aucuparia fruits have been underutilized despite their tremendous potential, this study aimed to correlate the in vitro antioxidant, antibacterial and cell-protective abilities of fruit extracts derived from Sorbus aucuparia Romanian cultivars with their phytochemical composition. Therefore, following the preparation of ethanolic and carotenoid extracts, phytochemical screening was performed using UV–Vis and HPLC-DAD-ESI-MS methods. The antioxidant activity was analyzed using DPPH and FRAP tests. As the results revealed high contents of bioactive compounds (polyphenols 1.11 mg GAE/g DM, flavonoids 430.06 µg QE/g DM and carotenoids 95.68 µg/g DM) and an important antiradical action (DPPH 24.51 mg/mL and FRAP 0.016 µM TE/mL), we chose to further examine the fruits’ biological properties. The antibacterial capacity was assessed employing agar well diffusion and broth microdilution techniques, with fruits displaying an intense activity against MSSA, MRSA and Enterococcus faecalis, but also E. coli and Pseudomonas aeruginosa. The cell-protective activity was analyzed on gentamicin-stressed renal cells, through MTT and Annexin V-FITC assays. Importantly, a significant increase in viability was registered on stressed cells following extract administration in low doses; nevertheless, viability was noticed to decline when exposed to elevated concentrations, potentially due to the cumulative actions of the extract and gentamicin. These findings offer novel light on the antibacterial activity of Sorbus aucuparia Romanian cultivars, as well as their cell-protective ability in renal cell injury.

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Section: Discussionmentioning

confidence: 99%

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

Aurori,

Niculae,

Hanganu

et al. 2024

Plants

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“…Aminoglycosides are antibiotics used to treat infections caused by Gram‐positive and Gram‐negative aerobes – either alone or in combination with active cell wall agents. Gentamicin (G) is the most widely administered antibiotic among all aminoglycosides, primarily to treat Gram‐negative bacterial infections (Ali et al, 2011 ; Althobaiti et al, 2023 ; Choi et al, 2011 ). However, taking it for more than 7 days can cause severe ototoxicity and nephrotoxicity (Ali, 2003 ; Ali et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Investigation of antimicrobial and antioxidant activities of Chenopodium album extracts and their effects on gentamicin nephrotoxicity in rats

Akbaş,

Kaya,

Makav

et al. 2023

Food Science & Nutrition

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This study aims to examine the antimicrobial and antioxidant activities of the aerial parts of Chenopodium album extracts (CAE) prepared with different solvents, and how C. album ethanol extract protects them against gentamicin‐induced nephrotoxicity. Extracts of C. album aerial parts were obtained from ethanol, water, methanol, chloroform, and hexane solvents. Thirty‐two male Wistar albino rats were used and gentamycin‐induced nephrotoxicity was utilized as a model. The water extract of C. album exhibited no antimicrobial effect, whereas the methanol one created the highest zone diameter on Bacillus cereus (26 mm). The methanol extract displayed the highest activity in DPPH and ABTS. The ethanol extract yielded the highest reducing power in the CUPRAC. The water extract had the highest reducing power in the FRAP. Concerning gentamicin‐induced renal damage, creatinine and urea levels in the blood were statistically higher in the gentamicin‐C. album group compared to the other groups (p < .05). Urea and creatinine levels of the gentamicin‐C. album group dropped significantly, indicating that the C. album was effective against renal damage. The sections from kidney tissues in the gentamicin + C. album group mostly exhibited mild glomerular congestion. Hyaline cast, cytoplasmic vacuolization, necrosis, and apoptosis were not observed. Thanks to C. album treatment, the gentamicin + C. album suffered less histopathological damage than the gentamicin group did. The results of the present study suggest that CAE can be used as a supportive treatment in people undergoing treatment for nephrotoxicity.

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Effect of Artemisia annua on kidney in gentamicin-induced nephrotoxicity in mice through regulation of the COX-2, NF-κB pathway

Cited by 2 publications

References 27 publications

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

Investigation of antimicrobial and antioxidant activities of Chenopodium album extracts and their effects on gentamicin nephrotoxicity in rats

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