Effect of arsenic acid withdrawal on hepatotoxicity and disruption of erythrocyte antioxidant defense system

Oyagbemi, Ademola Adetokunbo; Omóbòwálé, Temidayo Olutayo; Asenuga, Ebunoluwa Racheal; Afolabi, Jeremiah; Adejumobi, O.A.; Adedapo, Adeolu Alex; Yakubu, Momoh Audu

doi:10.1016/j.toxrep.2017.09.006

Cited by 13 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Substances that can initiate activity at the ARE include environmental pollutants, hydrogen peroxide and nitric oxide. The Nrf2-Maf-ARE complex then initiates subsequent speci c antioxidant and detoxi cation genes such as that of GST, GPx, GSH and SOD; thereby, increasing antioxidant activities and inactivating ROS (Baird and Dinkova-Kostova 2011; Oyagbemi et al 2017). The antioxidant effect of naringin was established as naringin restored the levels of GSH, GST, GP X , and SOD in the hepatic tissue of BPA-exposed chicks.…”

Section: Discussionmentioning

confidence: 99%

“…Birds are exposed BPA since plastic such as overhead water tanks, drinkers and feeding trays are normally utilized in poultry farms for some major activities (Escande et al 2006). Previous studies on animal models reported that BPA-induced oxidative stress caused a reprotoxic effect by affecting reproductive potential and is also hepatotoxic (Oyagbemi et al 2017;Kumar et al 2019). For instance, BPA caused sperm reserves reduction, shorter sperm transit time, and reduction in mitochondrial activity (Matuszczak et al 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Naringin mitigates Bisphenol A-induced hepatotoxicity in cockerel chicks

Esuola

Esan

Maikifi

et al. 2022

Preprint

View full text Add to dashboard Cite

Bisphenol A (BPA) is an environmental pollutant, a monomer used in the polymer industry to produce plastics. BPA has been reported to cause deleterious effects in both humans and animals. Naringin is one of the flavonoids with antioxidant and metal chelating properties. This study was carried out to assess the potential ameliorative effect of naringin on BPA-induced hepatotoxicity in cockerel chicks. Thirty-one-day old cockerel chicks used for this study were randomly divided into 6 groups of five chicks per group as follows: Group 1 (Control), Group 2 (BPA 100 mg/kg), Group 3 (BPA + 100 mg/kg naringin), Groups 4 (BPA + 200 mg/kg naringin), Group 5 (100 mg/kg naringin) and Group 6 (100 mg/kg naringin), respectively. The administration of BPA and naringin was through oral gavage. BPA intoxication precipitated significant (p < 0.05) increased ALT, ALP, AST, TC, TG, LDL, but decreased total protein and HDL-cholesterol when compared with the control. Also, there was a significant increase in hepatic H2O2 generation and MDA content with concomitant decrease in reduce glutathione, glutathione S-transferase, and superoxide dismutase activity in BPA intoxicated chicks. Histology revealed a moderate diffuse sinusoidal congestion, with a severe periportal cellular infiltration in BPA intoxicated chicks. Immunohistochemistry results revealed a higher expression of hepatic caspase 3 and TNF-α in chicks exposed to BPA alone relative to the control and chicks treated with naringin (100 mg/g and 200 mg/kg). Findings from this study showed that naringin administration restored hepatoxicity, improved antioxidant status, and lowered exaggerated values of cholesterol, oxidative stress indices, and ameliorated ultrastructure anarchy. Combining all, the incorporation of naringin into poultry feeds could position the flavonoid as a novel antioxidant and metal chelator with beneficial effects in the reduction of toxicities associated with environmental pollutants such as bisphenol A, thereby boosting production efficiency in livestock production.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Naringin mitigates Bisphenol A-induced hepatotoxicity in cockerel chicks

Esuola

Esan

Maikifi

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In macroalgae, organic As appears mostly as arsenosugars and, sometimes, as methyl derivatives [monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB)], while the inorganic forms are mainly represented by arsenate (AsV) and arsenite (AsIII). In general, organic forms exert low or no toxicity [ 147 , 148 ], while the inorganic are undoubtedly the most hazardous, with their accumulation being already associated to the development of several disorders, including nephrotoxicity, diabetes, hepatotoxicity, cardiovascular dysfunction, and cancer, mainly at the skin, lungs, and bladder level [ 149 , 150 , 151 , 152 ].…”

Section: Worries Related To Macroalgae Consumptionmentioning

confidence: 99%

Minerals from Macroalgae Origin: Health Benefits and Risks for Consumers

et al. 2018

View full text Add to dashboard Cite

Seaweeds are well-known for their exceptional capacity to accumulate essential minerals and trace elements needed for human nutrition, although their levels are commonly very variable depending on their morphological features, environmental conditions, and geographic location. Despite this variability, accumulation of Mg, and especially Fe, seems to be prevalent in Chlorophyta, while Rhodophyta and Phaeophyta accumulate higher concentrations of Mn and I, respectively. Both red and brown seaweeds also tend to accumulate higher concentrations of Na, K, and Zn than green seaweeds. Their valuable mineral content grants them great potential for application in the food industry as new ingredients for the development of numerous functional food products. Indeed, many studies have already shown that seaweeds can be used as NaCl replacers in common foods while increasing their content in elements that are oftentimes deficient in European population. In turn, high concentrations of some elements, such as I, need to be carefully addressed when evaluating seaweed consumption, since excessive intake of this element was proven to have negative impacts on health. In this regard, studies point out that although very bioaccessible, I bioavailability seems to be low, contrarily to other elements, such as Na, K, and Fe. Another weakness of seaweed consumption is their capacity to accumulate several toxic metals, which can pose some health risks. Therefore, considering the current great expansion of seaweed consumption by the Western population, specific regulations on this subject should be laid down. This review presents an overview of the mineral content of prevalent edible European macroalgae, highlighting the main factors interfering in their accumulation. Furthermore, the impact of using these marine vegetables as functional ingredients or NaCl replacers in foods will be discussed. Finally, the relationship between macroalgae’s toxic metals content and the lack of European legislation to regulate them will be addressed.

show abstract

“…Significant elevation of MDA levels in the brain and liver serves as a marker to measure tissue oxidative stress levels. It is well known that reduced glutathione (GSH) is involved in protection of normal cell structure and functions by maintaining the redox homeostasis, quenching free radicals and by participating in detoxification reactions [57]. GSH is a major endogenous antioxidant which counter balances free radical mediated damage.…”

Section: Discussionmentioning

confidence: 99%