Effect of aromatic ring–containing drugs on carnitine biosynthesis in rats with special regard to p-aminomethylbenzoic acid

Debreceni, Balázs; Farkas, Viktória; Fischer, Gábor; Sándor, Attila

doi:10.1016/j.metabol.2005.06.004

Cited by 1 publication

(1 citation statement)

References 22 publications

(25 reference statements)

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“…Glycine, which can be rate-limiting for benzoic acid conjugation 51 , was nominally lower in dogs with DCM, and increased post-intervention in dogs with DCM that ate NT diets at baseline. Of potential relevance to DCM are studies showing that sodium benzoate administration can alter carnitine metabolism in people and animal models 52 , and benzoic acid analogs have been shown to inhibit carnitine biosynthesis 53 . A definitive role for specific benzoates or benzoates as a chemical class cannot be concluded from our analyses, but in light of the importance of carnitine in fatty acid availability to the heart and the prominence of benzoates in plant-based ingredients, further research into a possible contributory role is warranted.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls

Smith

Parnell

Lai

et al. 2022

Sci Rep

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Dilated cardiomyopathy (DCM), caused by genetic and environmental factors, usually progresses to heart failure, a major cause of death in elderly people. A diet-associated form of DCM was recently identified in pet dogs eating non-traditional (NT) diets. To identify potential dietary causes, we analyzed metabolomic signatures and gene set/pathway enrichment in (1) all dogs based on disease, diet, and their interactions and (2) dogs with DCM based on diet. Metabolomic analysis was performed in 38 dogs with DCM eating NT diets (DCM-NT), 8 dogs with DCM eating traditional diets, 12 healthy controls eating NT diets, and 17 healthy controls eating traditional diets. Overall, 153 and 63 metabolites differed significantly between dogs with DCM versus healthy controls and dogs eating NT versus traditional diets, respectively, with 12 metabolites overlapping both analyses. Protein–protein interaction networks and gene set enrichment analysis identified 105 significant pathways and gene sets including aging-related pathways (e.g., nuclear factor-kappa B, oxidative damage, inflammation). Seventeen metabolites differed significantly in dogs with DCM eating NT versus traditional diets (e.g., fatty acids, amino acids, legume biomarkers), suggesting different mechanisms for primary versus diet-associated DCM. Our multifaceted metabolomic assessment of DCM in dogs highlighted diet’s role in some forms of DCM.

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Section: Discussionmentioning

confidence: 99%