Effect of Arginine‐Enriched Total Parenteral Nutrition on the Host‐Tumor Interaction in Cancer‐Bearing Rats

Oka, Toshinori; Ohwada, Katsuo; Nagao, M; Kitazato, Kenji

doi:10.1177/0148607193017004375

Cited by 20 publications

(6 citation statements)

References 19 publications

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“…Nutrition may in uence tumour growth since some tumours require large amounts of speci c nutrients (44), and deplete the body pool in tumour-bearing rats. Nutrients should meet host nutritional requirements but not tumour needs and therapeutic approaches should provide nutrients that improve the nutritional status of the host over that of the tumour (45,46). Therefore, the effects of GH and hyperproteic diets require further research in tumour-bearing models before their clinical use.…”

Section: Discussionmentioning

confidence: 99%

Effects of Growth Hormone Plus a Hyperproteic Diet on Methotrexate-induced Injury in Rat Intestines

Ortega

Segura²,

Breda-Vázquez³

et al. 2001

Acta Oncologica

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The aim of this study was to determine whether growth hormone treatment reduces injury to the intestinal mucosa induced by methotrexate (MTX). Wistar rats with intestinal injury induced by methotrexate were treated with daily growth hormone, beginning 3 days before MTX treatment until 3 or 4 days after MTX administration. The rats were killed at 3 or 7 days post-MTX administration. The rats were fed with either a normoproteic diet or a hyperproteic diet. Body weight, mortality, bacterial translocation, intestinal morphometry, proliferation and apoptosis and blood somatostatin and IGF-1 were determined. Combined administration of growth hormone and a hyperproteic diet reduces MTX-induced mortality. This effect was accompanied by increased cell proliferation and decreased apoptosis within the crypt. Morphometric data showed complete recovery of the mucosa by day 7 post-MTX administration. These results indicate a synergistic protective action of growth hormone combined with a hyperproteic diet to MTX-induced injury.

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Section: Discussionmentioning

confidence: 99%

Effects of Growth Hormone Plus a Hyperproteic Diet on Methotrexate-induced Injury in Rat Intestines

Ortega

Segura²,

Breda-Vázquez³

et al. 2001

Acta Oncologica

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“…After an abdominal operation and trauma, a negative N balance with progressive loss of body protein is observed, possibly resulting from hormonal changes and cytokine secretion (Fong et al 1990;Baigrie et al 1992). A report by Oka et al (1993) showed that TPN with Arg improved the host N balance in tumour-bearing rats. Fig.…”

Section: Discussionmentioning

confidence: 99%

Effects of arginine-containing total parenteral nutrition on N balance and phagocytic activity in rats undergoing a partial gastrectomy

et al. 2005

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The present study investigated the effect of arginine (Arg)-containing parenteral nutrition on phagocytic activity to elucidate the possible roles of Arg in the secretion of anabolic hormones and N balance in rats undergoing gastrectomy. Rats were divided into two experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN, the other group replaced 2 % of the total energy as Arg. After receiving TPN for 3 d, one-third of the rats in each experimental group were killed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 or 3 d after surgery. The results showed that there were no differences in N balance, plasma growth hormone and insulin-like growth factor-1 levels between the two groups before or after surgery. The phagocytic activity of peritoneal macrophages was higher in the Arg group than in the control group 1 d after surgery. There were no differences in the phagocytic activities of blood polymorphonuclear neutrophils between the two groups at various time points. TNF-a levels in peritoneal lavage fluid were lower in the Arg group than in the control group on post-operative day 3. These results suggest that parenterally infused Arg enhances phagocytic activity and reduces the production of inflammatory mediators at the site of injury. However, Arg supplementation did not influence the secretion of anabolic hormones nor N balance in rats with a partial gastrectomy.

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“…Urinary 3-methylhistidine was determined as previously described. 15 In the second experiment (analysis of tissue DNA or RNA synthesis), groups of 24 rats and 20 rats were randomized to receive one of two intravenous diets for 2 days and 7 days, respectively. The infusion methods were the same as described earlier.…”

Section: Methodsmentioning

confidence: 99%

Arginine‐Enriched Solution Induces a Marked Increase in Muscle Glutamine Concentration and Enhances Muscle Protein Synthesis in Tumor‐Bearing Rats

Oka

Ohwada

Nagao

et al. 1994

J Parenter Enteral Nutr

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Using a transplantable Yoshida sarcoma in a rat model of total parenteral nutrition (TPN), we measured the effectiveness of an arginine-enriched amino acid solution (AI-82) on muscle glutamine concentration and muscle protein synthesis compared with that of a conventional amino acid solution (Proteamin12). After tumor-bearing rats had been given one of two isocaloric TPN regimens for 6 days, [15N]glycine (99 atom %) containing TPN solution was infused into animals at a constant rate of 8 mg of [15N]glycine per hour for 18 hours, after which the liver, skeletal muscle (gastrocnemius muscle), and tumor protein synthesis rates were measured. A significantly increased whole muscle protein synthesis rate was observed in the AI-82 group; there was no difference in the whole liver and tumor protein synthesis rates between the two groups. When each TPN solution was administered for 1 week, muscle concentrations of arginine, ornithine, glutamine, and glutamate were considerably higher in the AI-82 group than in the Proteamin12 group, and these differences were also accompanied by a decrease in the plasma branched-chain amino acid (BCAA) (leucine, isoleucine, and valine) levels in the AI-82 group. The high levels of muscle glutamine concentration in the AI-82 group were investigated in connection with the high use of exogenous branched-chain amino acids.

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Effect of Arginine‐Enriched Total Parenteral Nutrition on the Host‐Tumor Interaction in Cancer‐Bearing Rats

Cited by 20 publications

References 19 publications

Effects of Growth Hormone Plus a Hyperproteic Diet on Methotrexate-induced Injury in Rat Intestines

Effects of Growth Hormone Plus a Hyperproteic Diet on Methotrexate-induced Injury in Rat Intestines

Effects of arginine-containing total parenteral nutrition on N balance and phagocytic activity in rats undergoing a partial gastrectomy

Arginine‐Enriched Solution Induces a Marked Increase in Muscle Glutamine Concentration and Enhances Muscle Protein Synthesis in Tumor‐Bearing Rats

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