Effect of arabinoxylan on colonic bacterial metabolites and mucosal barrier in high‐fat diet‐induced rats

Li, Shanshan; Sun, Yanan; Hu, Xinxin; Qin, Wen; Li, Cheng; Liu, Yuntao; Liu, Aiping; Zhao, Ye; Wu, Ding‐Tao; Lin, Derong; Zhang, Qing; Chen, Shuai; Chen, Hong

doi:10.1002/fsn3.1164

Cited by 14 publications

(14 citation statements)

References 46 publications

(57 reference statements)

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“…An hypocholesterolemic effect was also observed Lactobacillus paracasei M7 EPS in an in vitro model [ 106 ]. Several mechanisms have been proposed for the EPS activity, namely BS sequestration, deconjugation of BS and production of SCFA [ 107 , 108 , 109 , 110 ].…”

Section: Microbiota Bio-transformations Of Polysaccharides and Bile Salts: Hypocholesterolemic Implicationsmentioning

confidence: 99%

Polysaccharide Structures and Their Hypocholesterolemic Potential

et al. 2021

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Several classes of polysaccharides have been described to have hypocholesterolemic potential, namely cholesterol bioaccessibility and bioavailability. This review will highlight the main mechanisms by which polysaccharides are known to affect cholesterol homeostasis at the intestine, namely the effect (i) of polysaccharide viscosity and its influence on cholesterol bioaccessibility; (ii) on bile salt sequestration and its dependence on the structural diversity of polysaccharides; (iii) of bio-transformations of polysaccharides and bile salts by the gut microbiota. Different quantitative structure–hypocholesterolemic activity relationships have been explored depending on the mechanism involved, and these were based on polysaccharide physicochemical properties, such as sugar composition and ramification degree, linkage type, size/molecular weight, and charge. The information gathered will support the rationalization of polysaccharides’ effect on cholesterol homeostasis and highlight predictive rules towards the development of customized hypocholesterolemic functional food.

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Section: Microbiota Bio-transformations Of Polysaccharides and Bile Salts: Hypocholesterolemic Implicationsmentioning

confidence: 99%

Polysaccharide Structures and Their Hypocholesterolemic Potential

et al. 2021

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“…Furthermore, dietary fiber reduces transit time and increases satiety and intestinal motility. In addition to the immunomodulatory effects of polysaccharides, specifically arabinoxylan, a previous study showed that they regulate the level of lipopolysaccharides in the blood in the case of high-fat diets (Li et al, 2019).…”

Section: Analysis Of Microbial Communities With Different Substratesmentioning

confidence: 99%

In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

Zeyneb

Pei

Cao

et al. 2021

Food Science & Nutrition

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It has been shown that whole grains and dietary fiber are important for their fermentation characteristics in the large intestine, drawing more and more attention to quinoa and quinoa polysaccharides. In this study, we evaluated the prebiotic effect of quinoa seeds and quinoa polysaccharides after human simulated digestion. The modulatory effect of the quinoa and quinoa polysaccharides (QPs) on the gut microbiota was evaluated by the in vitro fermentation using human fecal microbiota. The yield of polysaccharides extraction was 15.45%. The digestibility of the cooked and uncooked quinoa after simulation of human digestion was 69.04% and 64.09%, respectively. The effect on the microbiota composition and their metabolic products was determined by the assessment of pH, short‐chain fatty acids (SCFAs), and changes in the bacterial population. After 24 hr anaerobic incubation, the total SCFAs of cooked, uncooked quinoa, and quinoa polysaccharides were 82.99, 77.11, and 82.73 mM, respectively with a pH decrease. At the phylum, genus, and class level, it has been found that the quinoa substrates enhance the growth of certain beneficial bacteria such as Prevotella and Bacteroides . Quinoa polysaccharides can be considered prebiotic due to their ability to increase Bifidobacterium and Collinsella . Principal component analysis (PCA) showed that there was a distinct modulating effect on the fecal microbiota which represents different distribution. Our research suggests that quinoa and quinoa polysaccharides have a prebiotic potential due to their association with the positive shifts in microbiota composition and short‐chain fatty acids production, which highlights the importance of further studies around this topic.

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“…Few studies have found increases in Lactobacillus with AX or AX-rich foods in a high-fat diet rat study [ 60 ], in two piglet feeding trials with AX from wheat (Naxus) [ 10 , 61 ], and in a double blinded, placebo-controlled, crossover human intervention study with AX-rich breakfast cereal intervention [ 62 ]. In contrast, another human intervention study consisting of wheat bran AX consumption showed no effect and even a decrease in Lactobacillus levels [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Extraction and characterisation of arabinoxylan from brewers spent grain and investigation of microbiome modulation potential

et al. 2021

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Purpose Brewers’ spent grain (BSG) represents the largest by-product of the brewing industry. Its utilisation as an animal feed has become less practical today; however, its high fibre and protein content make it a promising untapped resource for human nutrition. BSG contains mainly insoluble fibre. This fibre, along with protein, is trapped with the complex lignocellulosic cell structure and must be solubilised to release components which may be beneficial to health through modulation of the gut microbiota. Methods In this study, the application of a simultaneous saccharification and fermentation process for the extraction and solubilisation of arabinoxylan from BSG is demonstrated. Results Processing of the BSG was varied to modulate the physicochemical and molecular characteristic of the released arabinoxylan. The maximum level of arabinoxylan solubilisation achieved was approximately 21%, compared to the unprocessed BSG which contained no soluble arabinoxylan (AX). Concentration of the solubilised material produced a sample containing 99% soluble AX. Samples were investigated for their microbiome modulating capacity in in-vitro faecal fermentation trials. Many samples promoted increased Lactobacillus levels (approx. twofold). One sample that contained the highest level of soluble AX was shown to be bifidogenic, increasing the levels of this genus approx. 3.5-fold as well as acetate (p = 0.018) and propionate (p < 0.001) production. Conclusion The findings indicate that AX extracted from BSG has prebiotic potential. The demonstration that BSG is a source of functional fibre is a promising step towards the application of this brewing side-stream as a functional food ingredient for human nutrition.

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Effect of arabinoxylan on colonic bacterial metabolites and mucosal barrier in high‐fat diet‐induced rats

Cited by 14 publications

References 46 publications

Polysaccharide Structures and Their Hypocholesterolemic Potential

Polysaccharide Structures and Their Hypocholesterolemic Potential

In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota

Extraction and characterisation of arabinoxylan from brewers spent grain and investigation of microbiome modulation potential

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