Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level

Hamza, Fouad Ziedan; Al-Sharafi, Nabeel M. N.; Kasim, Sumayah Faruq

doi:10.33899/ijvs.2020.126872.1404

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Data were analyzed by one-way analysis of variance ANOVA and were performed using the minitab 18 program, The Tukey's test was used to compare significance between groups. The significance level was accepted at P<0.05 (12).…”

Section: Discussionmentioning

confidence: 99%

Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats

Al-Ameen¹,

Jirjees²,

Tawfeeq³

2022

IJVS

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Sodium benzoate (SB) is a white powder, used as preservative and food additive. Biochemical, physiological and histopathological effects of SB been tested in adult male rats. Twenty-four adult albino male rats aged100 day and weighted 250-350 g were used. Animals were divided into four groups. The first group considered as control, which received normal saline orally, other groups treated with SB by 300, 400 and 500 mg/kg of body weight respectively for 30 days. At the end of experiment, blood samples were collected from retro orbital sinus. Heart, liver, spleen, kidneys and brain were obtained for weight recording. The results indicated a significant decrease of super oxide dismutase SOD activity and a significant increase of nitric oxide NO level of treated group 500 mg/kg of body weight. Moreover, findings revealed that there are no significant changes in growth hormone GH activity and body weight. A significant reduction of heart weight of treated group 500 mg/kg of body weight were observed. The histopathological changes ranged from mild to severe in the brain cortex, as focal gliosis, satellitosis, mild vacuolation and vasogenic edema in treated groups with SB by different doses. Also, some changes were observed in liver represented by congestion of portal vein, mild hydropic degeneration of hepatocytes, stenosis of sinusoids, steatosis and necrosis of hepatocytes in treated groups with SB compared to control group. It concluded that short-term exposure to high doses of SB may be considered an oxidant substance that caused oxidative stress. Furthermore, SB can harm various organs in the body.

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Section: Discussionmentioning

confidence: 99%

Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats

Al-Ameen¹,

Jirjees²,

Tawfeeq³

2022

IJVS

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“…Thirty-two healthy albino male adult rats weighing 180-200 g were used in this investigation; they were bought from the animal house at the Faculty of Veterinary Medicine at the University of Kufa. Rats were housed at physiology animal house at Faculty of Medicine -University of Kufa in four-per-cage steel wire cages under sanitary conditions [17][18][19]. Before the trial began, rats spent one week getting used to their new surroundings.…”

Section: Samplingmentioning

confidence: 99%

Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats

Kasim,

Hamzah

2023

Kufa Jou. Vete. Med. Sci.

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Diabetes mellitus causes an increase in oxidative stress. Serotonin is a hormone its level in circulation reduced in diabetes; recently, it has been found to possess antioxidant qualities. The purpose of the study was to look at the impact of diabetes on pituitary-thyroid functioning, and serotonin role in modulating these effects in a streptozotocin-induced diabetes mellitus rat model. The thirty-tow healthy male rats with a body weight of 180-200 gm were split equally into 4 groups, group [1[: control, group [2]: Serotonin, group [3]: diabetic, and group [4]: Serotonin-diabetic. The rats were weighed and serum levels of glucose, insulin, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, serotonin, thyroid stimulating hormone, thyroxine, and triiodothyronine were measured. Our results presented that there was a significant increase in T3, T4, glucose, and MDA in the diabetic group compared to the control, while a significant decrease in T3, and T4, glucose, and MDA in the Serotonin with diabetic group compared to diabetic group. Furthermore, a significant decrease in TSH, serotonin, insulin and GPX, CAT, and SOD antioxidants in the diabetic group compared to control, while a significant increase in serum TSH, serotonin, insulin and CAT, GPX and SOD antioxidants in the Serotonin+diabetic group compared to diabetic group as well as a significant increase in serum insulin in the Serotonin group compared to all other groups. Serotonin plays a protective role against diabetes-induced and pituitary-thyroid disorder caused by diabetes which might be because of its antioxidant qualities and ability to maintain glucose and insulin balance.

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“…Moreover, although LH levels increased, the present study demonstrated a significant decline in serum testosterone levels in hyperthyroid male rats. Due to the changes in reproductive hormones, it can be confirmed that hyperthyroidism has an essential association with retard testicular function and male fecundity via affecting the reproductive axis (20,21). The testes and pituitary gland are among the target tissues for thyroid hormones.…”

Section: Reproductive Hormonesmentioning

confidence: 99%

“…Thyroid hormones (T4 and T3) perform their actions either directly through nuclear thyroid receptors or indirectly by interactions with various hormones and growth factors, such as testosterone and insulin-like growth factors (IGF), or by manipulating the release of hypothalamic gonadotropin releasing hormone (GnRH) and/or pituitary gonadotropic hormones (FSH and LH) (5). Moreover, it has been suggested that many cases of low fertility or infertility in animals could be related to thyroid dysfunction (6). Hyperthyroidism refers to a high production of THs, which must be differentiated from thyrotoxicosis, since thyrotoxicosis refers to the exposure of body tissues to high concentrations of thyroid hormones.…”

Section: Introductionmentioning

confidence: 99%

Effect of experimentally induced prepubertal hyperthyroidism on postubertal reproductive activity in male rats

Mohammad¹,

Al-Saaidi²

2022

IJVS

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This study was carried out to investigate the effect of induced prepubertal hyperthyroidism on the reproductive functions of male rats at the pubertal stage. Hyperthyroidism was induced by supplementing thyroxin in drinking water (0.002% w/v) and drenching of 200 μg/kg body weight. Sixty immature males (aged 50 days) were allocated to control and hyperthyroid (PH) groups, administered with distilled water and thyroxin, respectively. Each group was subdivided into three subgroups, sacrificed after 15 days (C15 and PH15), after administration for 15 days and left without treatment for 15 days (C15+ and PH15+), or after 30 days (C30 and PH30). After each period, body weight and relative weight of genital organs were recorded. Serum concentrations of thyroid stimulating hormone (TSH), thyroxin (TT4), triiodothyronine (TT3), follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone was assessed. The expression levels of testicular inha and thyroid hormone receptor (THR) genes were analyzed. Histopathological examination of testis was studied. Compared with control, PH group male rats showed decreased body weight gain and genital organ weights at all experimental periods, increased levels of serum TT4, TT3, and LH, decreased levels of TSH, FSH, and testosterone, and lower expression levels of testicular inha and THR genes. Testicular sections of PH group male rats, showed reduced germinal epithelium, vacuolation, and decreased the number of spermatocytes and Sertoli cells compared with control. In conclusion, the disturbed fluctuations of sex steroid hormones due to prepubertal hyperthyroidism might cause retardation of the testes' development.

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Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level

Cited by 3 publications

References 25 publications

Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats

Effect of sodium benzoate on some biochemical, physiological and histopathological aspects in adult male rats

Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats

Effect of experimentally induced prepubertal hyperthyroidism on postubertal reproductive activity in male rats

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