Effect of Aqueous Leaf Extract of Ocimum gratissimum on Antiretroviral Drug-Induced Hepatotoxicity in Rats

Ughachukwu, PO; Okonkwo, Paul; Nwozor, Cornelius; Okafor, Joseph; Nwafia, Ifeyinwa

doi:10.9734/ejmp/2016/23603

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Liver injury can occur as a result of ingestion of some drugs, chemicals, and herbs. Mechanism of drug-induced hepatic injury include: direct hepatic injury, immune reconstitution, hypersensitivity reaction, and mitochondrial injury 4,5,6,7 .…”

Section: Introductionmentioning

confidence: 99%

Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats

Kosi Emmanuel Ifemenam,

Cornelius Maduabuchi Nwozor,

Dennis Chukwujekwu Adinnu

et al. 2024

World J. Bio. Pharm. Health Sci.

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1 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku, Awka. Anambra State. Nigeria. 2 Department of Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli campus. Anambra State. Nigeria. 3 Department of General Medicine, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom. 4 Department of Gastroenterology, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom. 5 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Abia StateUniversity Teaching Hospital, Aba. Abia State. Nigeria.

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Section: Introductionmentioning

confidence: 99%

Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats

Kosi Emmanuel Ifemenam,

Cornelius Maduabuchi Nwozor,

Dennis Chukwujekwu Adinnu

et al. 2024

World J. Bio. Pharm. Health Sci.

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“…Ocimum gratissimum is a vegetable that is edible, so the chances of it being toxic are minimal. In fact, it has been demonstrated that its extract, when administered to albino rats for 28 days at a dose of 80 mg/kg did not result in any toxic effect to the liver (Ughachukwu et al, 2016). This plant, also known as scent leaf (nchuanwuin Igbo) belongs to the family Lamiaceaae and is commonly used in the treatment of fever, diarrhoea, dysentery, pile, and convulsions (Prabhu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Leaf Extract of Ocimum Gratissimum on some Haematological Indices in Rats Treated with Zidovudine-containing Antiretroviral Drugs

Ughachukwu¹,

Okonkwo²,

Nwozor³

et al. 2017

GJMS

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Background: Anaemia, one of the manifestations of HIV/AIDS, could be worsened by zidovudine-containing antiretroviral therapy. This may result in discontinuation of therapy, drug resistance, and increased mortality and morbidity. The medicinal plant, Ocimum gratissimum, is credited with haematopoetic properties. The study is aimed at finding out if the leaf extract of this plant will protect against anaemia in zidovudine-containing antiretroviral therapy. Methodology: 25 adult rats of both sexes were divided into 5 groups (A, B C, D, E) of 5 animals per group and given oral antiretroviral drugs and extract as follows: A (normal feeds only), B (efavirenz 8.6 mg/kg, abacavir 8.6 mg/kg, zidovudine 4.3 mg/kg), C (extract 80 mg/kg), D (efavirenz 8.6 mg/kg, abacavir 8.6 mg/kg, zidovudine 4.3 mg/kg, plus extract 40 mg/kg), E (efavirenz 8.6 mg/kg, abacavir 8.6 mg/kg, zidovudine 4.3 mg/kg, plus extract 80 mg/kg) all for 28 days. Thereafter, blood samples were collected and analyzed for haemoglobin and packed cell volume values using autoanalyzer. Data were tested for normality and further analyzed for statistical significance using Kruskal-Wallis test plus Dunn's multiple comparison using Graph Pad Prism 7.0. Results: Mean values (± S.E.M.) of haemoglobin were 12.

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Evaluation of therapeutic effect of Psidium guajava root extract against the toxicity induced by Ricinus communis (castor oil) in rats

et al. 2021

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Effect of Aqueous Leaf Extract of Ocimum gratissimum on Antiretroviral Drug-Induced Hepatotoxicity in Rats

Cited by 3 publications

References 23 publications

Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats

Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats

Effect of Aqueous Leaf Extract of Ocimum Gratissimum on some Haematological Indices in Rats Treated with Zidovudine-containing Antiretroviral Drugs

Evaluation of therapeutic effect of Psidium guajava root extract against the toxicity induced by Ricinus communis (castor oil) in rats

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