Effect of Aqueous Extract of &lt;i&gt;Dendropanax morbifera&lt;/i&gt; Leaf on Sexual Behavior in Male Rats

Jung, Myung-A; Oh, Kangho; Choi, Eun Jin; Kim, Yu jin; Bae, Donghyuck; Oh, Dool-Ri; Kim, Ki man; Kim, Dong-Wook; Choi, Chulyung

doi:10.12691/jfnr-5-7-10

Cited by 2 publications

(3 citation statements)

References 13 publications

(15 reference statements)

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“…The enhancement of libido may be due to an increase in the anterior pituitary hormone and serum testoster-one levels, which in turn stimulates sexual behavior (32,33). Recently, we reported that an aqueous DME affected the sexual behavior of male rats (17).…”

Section: Discussionmentioning

confidence: 99%

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In vitro and in vivo androgen regulation of Dendropanax morbiferus leaf extract on late-onset hypogonadism

Jung

Choi

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Late-onset hypogonadism (LOH) is associated with advancing age and is caused by a deficiency in serum testosterone levels. The aim of this study was to examine the effect of a Dendropanax morbiferus H.Lév. leaf extract (DME) on LOH using TM3 cells and aging male rats as in vitro and in vivo models, respectively. The in vitro effects of DME on testosterone levels and 3β-hydroxysteroid dehydrogenase (3β-HSD) protein expression in TM3 cells were analyzed.In the in vivo experiments, DME was orally administered to rats at three doses (50, 100, and 200 mg/kg/day) for 4 weeks. DME significantly increased the testosterone levels and 3β-HSD protein expression in TM3 cells. The DME groups showed significantly increased levels of androgenic hormones such as testosterone and dehydroepiandrosterone sulfate. The sex hormone-binding globulin production was significantly lower in the DME groups than that in the control group, while the neurohormone levels in the hypothalamic-pituitary-gonadal axis markedly increased. No significant differences were observed in the glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and prostate-specific antigen levels among the DME and control groups. The triglyceride and low-density lipoprotein cholesterol levels were significantly lower, while the high-density lipoprotein cholesterol levels were significantly higher in the DME groups than those in the control group. The latency time in the rotarod, treadmill, and swimming tests increased with the DME treatment. Furthermore, the sperm counts in the epididymis markedly increased. These results suggest that DME can be effectively used to alleviate the symptoms of LOH.

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Section: Discussionmentioning

confidence: 99%

“…We previously reported that an aqueous extract of D. morbiferus leaves affected the sexual behavior of male rats (17). Based on these results, we evaluated the ameliorating effect of DME on LOH using TM3 Leydig cells and aging male rats as in vitro and in vivo models, respectively.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo androgen regulation of Dendropanax morbiferus leaf extract on late-onset hypogonadism

Jung

Choi

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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“…In other research, the crude extracts of D. moribifera leaves seemed to exhibit higher immune activation activities and were used as an immunomodulatory agent [ 59 ]. D. morbifera leaf extracts also appear to be a useful natural resource for the management of sexual function [ 60 ]. Meanwhile, D. moribifera is also used in multi-therapeutic applications.…”

Section: Medicinal Uses and Pharmacological Properties Of mentioning

confidence: 99%

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

Balakrishnan¹,

Cho²,

Kim³

et al. 2020

Antioxidants

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The Dendropanax genus is a kind of flowering plant in the family of Araliaceae that encompasses approximately 91 to 95 species. Several Dendropanax species are used as traditional medicinal plants, extensively used Korea and South America and other parts of the world. Almost every part of the plant, including the leaves, bark, roots, and stems, can be used as traditional medicine for the prevention and management of a broad spectrum of health disorders. This paper sought to summarizes the ethnopharmacological benefits, biological activities, and phytochemical investigations of plants from the genus Dendropanax, and perhaps to subsequently elucidate potential new perspectives for future pharmacological research to consider. Modern scientific literature suggests that plants of the Dendropanax genus, together with active compounds isolated from it, possess a wide range of therapeutic and pharmacological applications, including antifungal, anti-complement, antioxidant, antibacterial, insect antifeedant, cytotoxic, anti-inflammatory, neuroprotective, anti-diabetic, anti-cancer, and anti-hypouricemic properties. The botanical descriptions of approximately six to 10 species are provided by different scientific web sources. However, only six species, namely, D. morbiferus, D. gonatopodus, D. dentiger, D. capillaris, D. chevalieri, and D. arboreus, were included in the present investigation to undergo phytochemical evaluation, due to the unavailability of data for the remaining species. Among these plant species, a high concentration of variable bioactive ingredients was identified. In particular, D. morbifera is a traditional medicinal plant used for the multiple treatment purposes and management of several human diseases or health conditions. Previous experimental evidence supports that the D. morbifera species could be used to treat various inflammatory disorders, diarrhea, diabetes, cancer, and some microbial infections. It has recently been reported, by our group and other researchers, that D. morbifera possesses a neuroprotective and memory-enhancing agent. A total of 259 compounds have been identified among six species, with 78 sourced from five of these species reported to be bioactive. However, there is no up-to-date information concerning the D. morbifera, its different biological properties, or its prospective benefits in the enhancement of human health. In the present study, we set out to conduct a comprehensive analysis of the botany, traditional medicinal history, and medicinal resources of species of the Dendropanax genus. In addition, we explore several phytochemical constituents identified in different species of the Dendropanax genus and their biological properties. Finally, we offer comprehensive analysis findings of the phytochemistry, medicinal uses, pharmacological actions, and a toxicity and safety evaluation of the D. morbifera species and its main bioactive ingredients for future consideration.

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Effect of Aqueous Extract of <i>Dendropanax morbifera</i> Leaf on Sexual Behavior in Male Rats

Cited by 2 publications

References 13 publications

In vitro and in vivo androgen regulation of Dendropanax morbiferus leaf extract on late-onset hypogonadism

In vitro and in vivo androgen regulation of Dendropanax morbiferus leaf extract on late-onset hypogonadism

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

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