EFFECT OF AQUEOUS EXTRACT (CRUDE) OF LEAVES OF &lt;i&gt;Vernonia Amygdalina&lt;/i&gt; (DEL) ON BLOOD GLUCOSE, SERUM ALBUMIN AND CHOLESTEROL LEVELS IN DIABETIC ALBINO RATS

Uhegbu, Friday O.; Ogbuehi, Kingsley J

doi:10.4314/gjpas.v10i1.16380

Cited by 15 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, several in vivo and in vitro antidiabetes investigations have been carried out on bitter leaf. Studies on the extracts from the leaves have indicated some blood sugar lowering effect in experimental animals (Akah and Okafor 1992;Uhegbu 2004). Erasto et al (2009) demonstrated that bitter leaves significantly increased glucose utilization in the C2C12 muscle and Chang liver cells but showed no effect on the 3T3-L1 cells.…”

Section: Introductionmentioning

confidence: 99%

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

Saliu

Ademiluyi

Akinyemi

et al. 2011

Journal of Food Biochemistry

View full text Add to dashboard Cite

Bitter leaf is a popular vegetable commonly consumed and which has been employed in traditional medicine for the prevention/management of diabetes and hypertension for centuries in the tropical Africa. However, possible mechanism underlining its hypoglycemic and antihypertension is not clear. Therefore, this study sought to investigate the inhibitory effect of free and bound phenol extracts of bitter leaf on key enzymes linked to type‐2 diabetes (α‐glucosidase and α‐amylase) and hypertension (angiotensin‐I converting enzyme [ACE]). The free and bound phenol extracts significantly (P < 0.05) inhibited α‐amylase and α‐glucosidase activities in vitro in a dose‐dependent pattern (4–16 µg/mL). However, the α‐glucosidase inhibitory activity of the extracts were significantly (P < 0.05) higher than their α‐amylase inhibitory activity. Furthermore, the ACE inhibitory activity of the extracts also followed a dose‐dependent pattern (5–20 µg/mL), and the bound phenol extract significantly (P < 0.05) inhibited ACE more than the free phenol extract. However, there exists a strong correlation between the enzyme inhibitory activities and the phenol content of the extracts. Therefore, the inhibition of α‐amylase, α‐glucosidase and ACE, coupled with the antioxidant activities of bitter leaf phenolic‐rich extracts, could be a possible mechanism through which Vernonia amygdalina exert its antidiabetes and antihypertension properties. PRACTICAL APPLICATION This manuscript deals with the possibilities of using phenolic extracts of bitter leaf as a nutraceutical source for the management of diabetes and hypertension.

show abstract

Section: Introductionmentioning

confidence: 99%

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

Saliu

Ademiluyi

Akinyemi

et al. 2011

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

“…The in vivo antidiabetic assay of the aqueous extracts from the leaves of this plant has indicated some blood sugar lowering effect in rats (Uhegbu, 2004). However, the mode of action of the extracts in lowering blood sugar in diabetic rats was uncertain.…”

Section: Introductionmentioning

confidence: 99%

Effect of leaf extracts ofVernonia amygdalinaon glucose utilization in chang-liver, C₂C₁₂muscle and 3T3-L1 cells

Erasto¹,

Venter²,

Roux³

et al. 2009

Pharmaceutical Biology

View full text Add to dashboard Cite

“…Local names by which the plant is called in Nigeria include: Kiriologbo (in Ijaw); Onugbu (in Igbo), Ewuro (in Yoruba) and Shiwaka (in Hausa) [4]. The leaves and bark in Ethiopian local medicine are used as purgative, against menstrual pain and wound dressing [6,7]. It is also documented that V. amygdalina has been used traditionally in blood clotting and has elicited a significant reduction in blood glucose levels at post-prandial time point.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Assessment of Crude and Fractionated Extracts of Vernonia amygdalina Leaf against Multiple Antibiotic Resistant Bacteria of Wound Infection

Onifade

Agunloye

2019

AJRIMPS

View full text Add to dashboard Cite

This study was conducted to determine the antibacterial effect of crude and fractionated extracts of leaves of Vernonia amygdalina against multiple antibiotic resistant bacteria isolate from wounds. The bacteria isolates obtained are: Staphylococcus aureus, Escherichia coli, Pseudomonas aeuroginosa, Klebsiella pneumoniae, Proteus mirabilis and Streptococcus pyogene; they were confirmed standard microbiological techniques. Extracts were prepared from the leaf of the plant using ethanol, chloroform, cold water and hot water. The antibacterial activities of the crude extracts were assayed using the agar well diffusion methods. Multiple antibiotic resistant of the isolates was confirmed in the six (6) isolates. The phytochemical screening revealed the presence of alkaloids, phenols and saponins. All the extract showed varying degrees of activities depending on the extract concentration and the extract solvent. Generally, ethanol rated best as the extraction solvent which was able to inhibit all isolates except K. pneumoniae and P. mirabilis, and inhibits S. aureus at 50 mg/ml with zones 6.997±0.003. The antibacterial efficacy of the extract increases with a corresponding increase in the extract concentration. The MBC values ranged from 50 - 400 mg/mL for all the extraction solvent, and this is very important for people who depend on the plant for their health care needs. Fra 1, 6, and 10 of the column fractions were able to inhibit with 8.997 ± 0.008 mm, 8.993 ± 0.012 mm and 9.007 ± 0.000 mm respectively. The functional groups are Alkene, alkane group, alkyl halides, N-H bend of amides and Alcohol. The leaf of Vernonia amgydalina can be used as a raw material for the production of new antibiotic to control multiple resistant bacteria.

show abstract

EFFECT OF AQUEOUS EXTRACT (CRUDE) OF LEAVES OF <i>Vernonia Amygdalina</i> (DEL) ON BLOOD GLUCOSE, SERUM ALBUMIN AND CHOLESTEROL LEVELS IN DIABETIC ALBINO RATS

Cited by 15 publications

References 0 publications

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

Effect of leaf extracts ofVernonia amygdalinaon glucose utilization in chang-liver, C₂C₁₂muscle and 3T3-L1 cells

Antibacterial Assessment of Crude and Fractionated Extracts of Vernonia amygdalina Leaf against Multiple Antibiotic Resistant Bacteria of Wound Infection

Contact Info

Product

Resources

About

EFFECT OF AQUEOUS EXTRACT (CRUDE) OF LEAVES OF <i>Vernonia Amygdalina</i> (DEL) ON BLOOD GLUCOSE, SERUM ALBUMIN AND CHOLESTEROL LEVELS IN DIABETIC ALBINO RATS

Cited by 15 publications

References 0 publications

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

IN VITROANTIDIABETES AND ANTIHYPERTENSION PROPERTIES OF PHENOLIC EXTRACTS FROM BITTER LEAF (VERNONIA AMYGDALINADEL.)

Effect of leaf extracts ofVernonia amygdalinaon glucose utilization in chang-liver, C2C12muscle and 3T3-L1 cells

Antibacterial Assessment of Crude and Fractionated Extracts of Vernonia amygdalina Leaf against Multiple Antibiotic Resistant Bacteria of Wound Infection

Contact Info

Product

Resources

About

Effect of leaf extracts ofVernonia amygdalinaon glucose utilization in chang-liver, C₂C₁₂muscle and 3T3-L1 cells