Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study

Cicero, Arrigo Francesco Giuseppe; Caliceti, Cristiana; Fogacci, Federica; Giovannini, Marina; Calabria, Donato; Colletti, Alessandro; Veronesi, Maddalena; Roda, Aldo; Borghi, Claudio

doi:10.1002/mnfr.201700373

Cited by 50 publications

(56 citation statements)

References 38 publications

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“…In a dietary crossover study evaluating the effects of clear and cloudy apple juices, whole apples, and apple pomace on plasma lipids, there was a small decrease in total cholesterol and LDL‐C in the whole apple intervention group, that did not reach statistical significance when compared to the control . While the present study did not show any significant decrease in fasting plasma glucose, a recently published study by Cicero et al., demonstrated a decrease after 8 weeks supplementation with an apple polyphenol extract …”

Section: Discussioncontrasting

confidence: 79%

Flavonoid‐Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

Bondonno

Blekkenhorst

et al. 2017

Molecular Nutrition Food Res

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Section: Discussioncontrasting

confidence: 79%

Flavonoid‐Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

Bondonno

Blekkenhorst

et al. 2017

Molecular Nutrition Food Res

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“…Patients' personal history was evaluated taking particular attention to CVD and other diseases, dietary and smoking habits assessment (both evaluated with validated semiquantitative questionnaires; Cicero et al, ), physical activity, and pharmacological treatment.…”

Section: Methodsmentioning

confidence: 99%

Three‐arm, placebo‐controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects

Cicero

Fogacci

Bove

et al. 2019

Phytotherapy Research

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Our double-blind, placebo-controlled, parallel-group, dose-escalation, clinical trial aimed to test the effect of a combined nutraceutical containing bergamot extract (120-mg flavonoids), phytosterols, vitamin C, and chlorogenic acid from dry artichoke extract on 90 overweight dyslipidemic subjects. Participants were randomly allocated to treatment with two pills of either active treatment or placebo, or a combination of both (a pill per treatment). After 8 weeks, all active-treated groups experienced a significant improvement in triglycerides (TG) versus placebo and in low-density lipoprotein cholesterol (LDL-C) versus baseline and placebo treatments. In the high-dosetreated group, also total cholesterol (TC), nonhigh-density lipoprotein cholesterol (non-HDL-C), γ-glutamil transpeptidasi, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) significantly decreased. At 24-week follow-up, TG levels maintained lower than baseline in all groups. All patients allocated to either low-dose or high-dose active treatment experienced a significant decrease in TG, LDL-C, and homeostatin model assessment of insulin resistance. In subjects taking high-dose active treatment, adiponectin significantly increased, whereas TC, non-HDL-C, insulin (fasting plasma insulin), leptin, leptin/adiponectin ratio, hs-CRP, and TNF-α were significantly reduced. The tested nutraceutical showed to improve lipid and glucose metabolism, adipokines pattern, and systemic inflammation in dyslipidemic overweight subjects.

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“…Subjects' personal history was evaluated taking particular attention to cardiovascular and metabolic diseases, dietary and smoking habits assessment (both evaluated with validated semi-quantitative questionnaires) [13], physical activity, and pharmacological treatments.…”

Section: Clinical Data and Anthropometric Measurementsmentioning

confidence: 99%

A Randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study

et al. 2020

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The Beta-glucan Effects on Lipid profile, glycemia and inTestinal health (BELT) Study investigated the effect of 3 g/day oat beta-glucans on plasma lipids, fasting glucose and self-perceived intestinal well-being. The Study was an 8-week, double-blind, placebo-controlled, cross-over randomized clinical trial, enrolling a sample of 83 Italian free-living subjects, adherent to Mediterranean diet, with a moderate hypercholesterolemia and a low cardiovascular risk profile. Beta-glucans reduced mean LDL-Cholesterol (LDL-C) levels from baseline by 12.2% (95%CI: −15.4 to −3.8) after 4 weeks of supplementation and by 15.1% (95%CI: −17.8 to −5.9) after 8 weeks of supplementation (p < 0.01 for both comparison and versus placebo). Between baseline and 4 weeks Total Cholesterol (TC) levels showed an average reduction of 6.5% (95%CI: −10.9 to −1.9) in the beta-glucan sequence; while non-HDL-C plasma concentrations decreased by 11.8% (95%CI: −14.6 to −4.5). Moreover, after 8 weeks of beta-glucan supplementation TC was reduced by 8.9% (95%CI: −12.6 to −2.3) and non-HDL-C levels by 12.1% (95%CI: −15.6 to −5.3). Decreses in TC and non HDL-C were significant also versus placebo (respectively p < 0.05 and p < 0.01 to both follow-up visits). Fasting plasma glucose and self-perceived intestinal well-being were not affected by both beta-glucan and placebo supplementation.

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Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study

Abstract: In vivo, apple polyphenols extract has a positive effect on vascular oxidative stress and endothelium function and reduce FPG and uric acid by inhibiting xanthine oxidase, as our In vitro experiment attests.

Cited by 50 publications

References 38 publications

Flavonoid‐Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

Flavonoid‐Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

Three‐arm, placebo‐controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects

A Randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study

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