Effect of apple peel extract on diabetes-induced peripheral neuropathy and wound injury

Kamdi, Sandesh P.; Raval, Amit D.; Nakhate, Kartik T.

doi:10.1007/s40200-020-00719-6

Cited by 10 publications

(2 citation statements)

References 47 publications

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“…The deposition of excess body fat leads to obesity, diabetes, atherosclerosis and several other metabolic disorders. We utilized the HFD and STZ treatment to simulate the diabetic state in mice, similar to in a clinical condition [ 24 , 25 , 26 , 27 ]. A significant weight gain was observed in mice kept on HFD compared to the chow diet-fed animals, although curcumin treatment led to the maintenance of body weight even in the presence of HFD [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors

Pawar

Mahajan

Nakhate

et al. 2022

Life

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Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist. Since CB2R is involved in cardioprotective functions, we explored its role in ameliorative actions of curcumin against myocardial damage triggered by isoproterenol in diabetic animals. Mice were kept on a high-fat diet (HFD) throughout the experiment (30 days). Following 7 days of HFD feeding, streptozotocin was administered (150 mg/kg, intraperitoneal) to induce diabetes. From day 11 to 30, diabetic mice received either curcumin (100 or 200 mg/kg/day, oral), CB2R antagonist AM630 (1 mg/kg/day, intraperitoneal) or both, with concurrent isoproterenol (150 mg/kg, subcutaneous) administration on day 28 and 29. Diabetic mice with myocardial infarction showed an altered hemodynamic pattern and lipid profile, reduced injury markers, antioxidants with increased lipid peroxidation in the myocardium, and elevated glucose and liver enzymes in the blood. Moreover, an increased pro-inflammatory markers, histological severity, myonecrosis, and edema were observed. Curcumin compensated for hemodynamic fluctuations, restored biochemical markers, preserved antioxidant capacity, decreased cytokines levels, and restored cardiac functionality. However, the AM630 pre-treatment attenuated the effects of curcumin. The data suggest the involvement of CB2R in the actions of curcumin such as in the prevention of myocardial stress and in the improvement of the normal status of the myocardial membrane associated with diabetes.

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Section: Discussionmentioning

confidence: 99%

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors

Pawar

Mahajan

Nakhate

et al. 2022

Life

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“…Interestingly, it was reported that the hexosamine of DW tissue decreased compared with the normal control group in streptozotocininduced diabetic rats [146]. Topical application of apple peel extract (APE) significantly increased hydroxyproline and hexosamine levels, thereby enhancing the DW healing process [145]. The application of natural biologics, such as ethanolic extracts of Melia dubia [146] and Solanum xanthocarpum [147] (more examples are shown in the Table 1), during the wound repair in diabetic rats promotes the deposition of hexosamine, which eventually accelerates the wound repair.…”

Section: Hexosamine Pathwaysmentioning

confidence: 99%

Natural Biologics Accelerate Healing of Diabetic Foot Ulcers by Regulating Oxidative Stress

Song¹,

Liu²,

Liu³

et al. 2022

Front. Biosci. (Landmark Ed)

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Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge. Although current treatments such as debridement, offloading, and infection control have resulted in partial improvement in DFU, the incidence, amputation, and mortality rates of DFU remain high. Therefore, there is an urgent need to find new or more effective drugs. Numerous studies have shown that oxidative stress plays an important role in the pathophysiology of DFU. The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway and the advanced glycated end products (AGEs)-receptor for advanced glycation endproducts (RAGE), protein kinase C (PKC), polyol and hexosamine biochemical pathways play critical roles in the regulation of oxidative stress in the body. Targeting these pathways to restore redox balance can control and alleviate the occurrence and development of DFU. Natural biologics are a major source of potential drugs for these relevant targets, and their antioxidant potential has been extensively demonstrated. Here, we discussed the pathophysiological mechanism of oxidative stress in DFU, and identifiled natural biologics targeting these pathways to accelerate DFU healing, in order to provide a new or potential direction for clinical treatment, nursing and related basic research of DFU.

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Phloridzin ameliorates type 2 diabetes‐induced depression in mice by mitigating oxidative stress and modulating brain‐derived neurotrophic factor

Kamdi

Raval

Nakhate³

2021

J Diabetes Metab Disord

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Effect of apple peel extract on diabetes-induced peripheral neuropathy and wound injury

Cited by 10 publications

References 47 publications

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors

Natural Biologics Accelerate Healing of Diabetic Foot Ulcers by Regulating Oxidative Stress

Phloridzin ameliorates type 2 diabetes‐induced depression in mice by mitigating oxidative stress and modulating brain‐derived neurotrophic factor

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