Effect of apple intake on fecal microbiota and metabolites in humans

Shinohara, Kenji; Ohashi, Yuji; Kawasumi, Koh; Terada, Atsushi; Fujisawa, Tomohiko

doi:10.1016/j.anaerobe.2010.03.005

Cited by 110 publications

(80 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pseudomonas spp., for example, are well adapted to colonize the mucosa (Tsang et al, 1994;Aristoteli and Willcox, 2003) and have been identified in human intestinal and mucosal studies (Aristoteli and Willcox, 2003;Shinohara et al, 2010). Many of the other bacteria enriched on the mucosa, such as Campylobacter spp., Weissella spp, and Sutterella spp., are known mucosal colonizers or pathogens and are likely mucosal specialists (On, 1996).…”

Section: Discussionmentioning

confidence: 99%

Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations

Looft

Allen

Cantarel³

et al. 2014

The ISME Journal

329

265

View full text Add to dashboard Cite

Disturbance of the beneficial gut microbial community is a potential collateral effect of antibiotics, which have many uses in animal agriculture (disease treatment or prevention and feed efficiency improvement). Understanding antibiotic effects on bacterial communities at different intestinal locations is essential to realize the full benefits and consequences of in-feed antibiotics. In this study, we defined the lumenal and mucosal bacterial communities from the small intestine (ileum) and large intestine (cecum and colon) plus feces, and characterized the effects of in-feed antibiotics (chlortetracycline, sulfamethazine and penicillin (ASP250)) on these communities. 16S rRNA gene sequence and metagenomic analyses of bacterial membership and functions revealed dramatic differences between small and large intestinal locations, including enrichment of Firmicutes and phage-encoding genes in the ileum. The large intestinal microbiota encoded numerous genes to degrade plant cell wall components, and these genes were lacking in the ileum. The mucosaassociated ileal microbiota harbored greater bacterial diversity than the lumen but similar membership to the mucosa of the large intestine, suggesting that most gut microbes can associate with the mucosa and might serve as an inoculum for the lumen. The collateral effects on the microbiota of antibiotic-fed animals caused divergence from that of control animals, with notable changes being increases in Escherichia coli populations in the ileum, Lachnobacterium spp. in all gut locations, and resistance genes to antibiotics not administered. Characterizing the differential metabolic capacities and response to perturbation at distinct intestinal locations will inform strategies to improve gut health and food safety.

show abstract

Section: Discussionmentioning

confidence: 99%

Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations

Looft

Allen

Cantarel³

et al. 2014

The ISME Journal

329

265

View full text Add to dashboard Cite

show abstract

“…A study from Walker et al (2011) showed partial agreement with the above results and indicated that RS diet could also increase the abundance of the Oscillibacter group [15]. Pectin from apple intake was said to be associated with an increase in the abundances of Bifidobacterium, lactobacilli and streptococci and a corresponding reduction in the abundances of Enterobacteriaceae, Pseudomonas and some lectithinase-positive clostridia [21].…”

Section: Diet Influences the Composition Of Gut Microbiotamentioning

confidence: 74%

Impact of diet on the human intestinal microbiota

Tan

O’Toole

2015

Current Opinion in Food Science

View full text Add to dashboard Cite

“…For example, regular consumption of apples (two per day for 2 weeks) increased the numbers of fecal bifidobacteria and decreased the C. perf ringens count. 197 Similarly, the concomitant dietary presence of apple polyphenols and FOS increased SCFA production. 198 In contrast, compared to consumption of an inulin-containing diet alone, including a grapefruit flavonoidrich extract decreased both production of SCFAs and the bifidobacteria population.…”

Section: Microbiota Interactionsmentioning

confidence: 99%

Emerging Aspects of Food and Nutrition on Gut Microbiota

He¹,

Marco²,

Slupsky³

2013

J. Agric. Food Chem.

View full text Add to dashboard Cite

The human gastrointestinal tract contains a highly complex ecosystem that harbors various microorganisms, which together create a unique environment within each individual. There is growing awareness that dietary habits are one of the essential factors contributing to the microbial diversity and community configuration that ultimately affects human health. From an evolutionary perspective, human dietary history can be viewed as a central factor in the selection of the gut microbial community and stabilization of the mutualistic host−microbial interaction, that together drive host phenotype. Herein, current knowledge concerning the influence of major dietary macrostructure and individual food ingredients is presented. This knowledge will provide perspectives for personalized gut microbiota management and, ultimately, movement toward an era of personalized nutrition and medicine. KEYWORDS: gut microbiome, diet, nutrition, food, colon, dietary fiber ■ INTRODUCTIONWe live in an intimate relationship with microorganisms that are present on the surfaces and cavities of the human body. During birth, or shortly thereafter, microbes from the mother's skin and milk, the air, and inanimate objects enter the virtually germ-free system of the neonate and proliferate to a dramatic extent. The gastrointestinal (GI) tract is the most densely populated microbial ecosystem of the mammalian host. Bacterial cells are most abundant, but other types of microbes are also present in the GI tract, such as archaea, viruses, protozoa, and fungi. The intestinal lumen alone harbors 10 times more bacterial cells than eukaryotic cells in the entire human body, an amount equivalent to approximately 1 kg of human mass.1 This fact leads us to view ourselves as "superorganisms", being composed of our cells as well as microbial cells that are dependent on each another for survival. 2Food is a major source of energy that promotes growth and development, immunity, and tissue repair, as well as homeostatic regulation. It is also an important energy source for gut microbiota.3,4 Although most nutrient absorption occurs in the small intestine, the colon harbors the majority of bacterial colonists. The colon can be viewed as the major site for "co-metabolic" activity, which enhances the efficiency of the energy harvest from foods 5,6 and influences the synthesis, bioavailability, and function of nutrients, 4 vitamins, 7,8 and drugs.9,10 Thus, the functional interaction between microbes and their host explains individual variability of nutrient metabolism and bioavailability.11 Understanding the relationship between the gut microbiome and diet is important for the development of next-generation therapeutic foods that target these microbes in health-promoting ways and will ultimately usher us toward an era of personalized nutrition and medicine.In this paper, current knowledge of the gut microbiome from the perspective of human dietary history and the coevolutionary relationship with the host will be broadly reviewed. The impact of major dietary...

show abstract

Effect of apple intake on fecal microbiota and metabolites in humans

Cited by 110 publications

References 20 publications

Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations

Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations

Impact of diet on the human intestinal microbiota

Emerging Aspects of Food and Nutrition on Gut Microbiota

Contact Info

Product

Resources

About