Effect of Antiviral Agents on Atherosclerosis in Patients with Chronic Hepatitis C

Solís, Juan; López, Ervin Saúl Enciso; Bautista-Santos, A.; Garay, Juan Carlos Anda; Rodríguez, Jose Luis Calixto; Alcántar, Rosalba Moreno; Montiel-López, Luis

doi:10.1016/j.arcmed.2021.04.009

Cited by 3 publications

(8 citation statements)

References 32 publications

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“…The reduction of cIMT seems to be irrespective of the increase in TC showed after viral eradication, whereas both studies observed an amelioration in fasting glucose 21,52 . Interestingly, another study conducted in patients without T2DM showed a significant reduction in the percentage of patients with carotid plaques after SVR despite cIMT did not significantly differ both as a linear value and as a percentage of increased cIMT 53 …”

Section: Resultsmentioning

confidence: 85%

“…Concerning HDL, 17 studies did not show a significant change after SVR, 20 studies observed an increase in HDL after SVR, especially in female patients with metabolic syndrome, 22,45,64,72,95 but not during the treatment when HDL declined, 13,91,96 and only 2 studies revealed a reduction in HDL 61,91 . Finally, 19 studies did not show significant changes in TGs after viral eradication, 13,22,26,40,45,46,53,60,73,74,97–103 in 16 TGs worsened, 12,16,28,36,37,39,52,58,61,64,68,72,91,92,104,105 and in 9 studies TGs decreased after SVR 38,43,54–56,69,79,106,107 …”

Section: Resultsmentioning

confidence: 99%

“…21,52 Interestingly, another study conducted in patients without T2DM showed a significant reduction in the percentage of patients with carotid plaques after SVR despite cIMT did not significantly differ both as a linear value and as a percentage of increased cIMT. 53 Notably, one study showed the opposite result. The authors evaluated both the greatest cIMT value measured, defined as max-cIMT, and the mean-cIMT derived from three measurements.…”

Section: Changes In Carotid Atherosclerosismentioning

confidence: 99%

“…Conversely, 7 studies revealed an increase in BMI after SVR, 27,40,90,[114][115][116][117] while 3 studies showed a reduction in mean BMI. 53,81,118 Increase in weight/BMI. The baseline presence of IR, the worsening of steatosis after SVR, higher fibrosis stage/cirrhosis, younger age, and moderate alcohol consumption seem to be the factors related to the increase in BMI after SVR.…”

Section: Changes In Lipid Parametersmentioning

confidence: 99%

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Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Cespiati,

Coelho Rodrigues,

Santos

et al. 2024

Liver International

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Background and AimsThe beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra‐hepatic metabolic features is underreached. This systematic review aimed to synthesize the evidence on the impact of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, glucidic impairment, dyslipidaemia, and weight gain.MethodsA systematic search of the existing literature (up to December 2022) identified 97 original studies that fulfilled the inclusion criteria.ResultsWhereas total cholesterol and low‐density lipoprotein (LDL) seem to increase after viral eradication, the cardiovascular damage expressed as carotid plaques and intima‐media thickness seems to improve. Otherwise, the effect on liver steatosis, glucidic homeostasis, and weight seems to be strictly dependent on the presence of baseline metabolic disorders.ConclusionDespite high heterogeneity and relatively short follow‐up of included studies, we can conclude that the presence of metabolic risk factors should be strictly evaluated due to their impact on liver steatosis, glucidic and lipid homeostasis, and on weight gain to better identify patients at risk of liver disease progression despite the virus eradication.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Changes In Carotid Atherosclerosismentioning

confidence: 99%

Section: Changes In Lipid Parametersmentioning

confidence: 99%

See 2 more Smart Citations

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Cespiati,

Coelho Rodrigues,

Santos

et al. 2024

Liver International

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“…In addition to directly attacking vascular endothelium, oxidative stress contributes to inducing inflammation ( Domingueti et al, 2016 ; Bai et al, 2020 ), which has been confirmed in a variety of cardio- and cerebrovascular diseases, such as atherosclerosis (e.g., ox-LDL), diabetes (e.g., high glucose and glycosylation end products), and hypertension (angiotensin II [Ang II]) ( Pleskovič et al, 2017 ; Solis et al, 2021 ). Further research has shown that the mechanism of inflammatory response involves a variety of microRNAs (miR-126, miR-155, miR-221/222, miR-31, miR-17-3p, miR-10a, miR-663, miR-125a-5p, and miR-125b-5p) by regulating downstream target proteins (such as VCAM-1, RGS16, Ets-1, AT1R, E-selectin, ICAM-1, MAP3K7, and βTRC) ( Forouzanfar and Asgharzade, 2020 ; Wu et al, 2020 ; Luan et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Research progress in endothelial cell injury and repair

Huang

Song

et al. 2022

Front. Pharmacol.

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Endothelial cells, which are important metabolic and endocrine cells, play an important role in regulating vascular function. The occurrence and development of various cardiovascular and cerebrovascular diseases are associated with endothelial dysfunction. However, the underlying mechanism of vascular endothelial injury is not fully understood. It has been reported that the mechanism of endothelial injury mainly involves inflammation and oxidative stress. Moreover, endothelial progenitor cells are regarded as important contributors in repairing damaged endothelium. Multiple interventions (including chemical drugs and traditional Chinese medicines) exert endothelial protection by decreasing the release of inducing factors, suppressing inflammation and oxidative stress, and preventing endothelial cell senescence.

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Chronic Hepatitis B, C, and stroke; association and pathophysiology

Hamza Imran,

Adnan Yousuf,

Mohammad Wasay

2023

PJNS

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Background and Objectives: Hepatitis infection may raise the incidence of stroke and other cerebrovascular abnormalities, according to several studies. However, its association is controversial. This review looked to compile the most recent research on the relationship between HBV and HCV, atherosclerosis, and stroke. Methods: This article reviews the literature on the connection between hepatitis B and C viruses with stroke and atherosclerosis. The search included articles from PubMed, PakMediNet, and Google Scholar, as well as a Medline search using specific keywords and MeSH terms. A total of 2655 articles were identified. Out of these 2655 articles we identified 134 articles in English for review. These 134 articles comprised of original studies, individual case studies, and retrospective cohorts. The review included original research, individual case reports, and retrospective cohorts published after 1990. Studies addressing co-infection with HIV were excluded. Results: After the screening, many articles were selected which included several topics of discussion under the said heading. The studies were closely examined to gather pertinent information relevant to the review's objectives. Most of the literature emphasized the link between chronic hepatitis and the risk of stroke. Conclusion: Although current evidence does tilt the scale in favor of hepatitis-causing cerebrovascular disease, this review study has some limitations, such as the lack of prospective cohorts and limited evidence for the natural history of hepatitis patients in relation to cardiovascular and cerebrovascular diseases.

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Effect of Antiviral Agents on Atherosclerosis in Patients with Chronic Hepatitis C

Cited by 3 publications

References 32 publications

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Research progress in endothelial cell injury and repair

Chronic Hepatitis B, C, and stroke; association and pathophysiology

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