Effect of antipsychotic treatment on Insulin-like Growth Factor-1 and cortisol in schizophrenia: A longitudinal study

Venkatasubramanian, Ganesan; Chittiprol, Seetharamaiah; Neelakantachar, Narendran; Shetty, Taranath K.; Gangadhar, Bangalore N.

doi:10.1016/j.schres.2010.01.033

Cited by 75 publications

(68 citation statements)

References 43 publications

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“…Second, as we sampled blood for hormone measurements only at a single point, the diurnal variation of the hormone levels was unknown. Third, since all patients were receiving antipsychotics, such medication may have influenced HPA axis function as has been demonstrated [50,51]. Although we did not find any significant correlations between antipsychotic dosage and hormonal measures, we have to acknowledge that our data on the chlorpromazine equivalents are themselves limited in that the inpatients were in the midst of their acute treatment and thus the prescription of antipsychotics tended to be frequently changed around the time of the hormone measurement.…”

mentioning

confidence: 71%

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Hori¹

2012

TONEUROPPJ

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Abstract:Earlier studies have used the dexamethasone (DEX) suppression test (DST) to investigate the hypothalamicpituitary-adrenal (HPA) function in schizophrenia, although the findings are controversial. Recently there has been an increased interest in the role of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) in HPA axis function. Several studies have investigated basal DHEA(S) levels and cortisol/DHEA(S) ratios in schizophrenia patients, while no attempts have been made to investigate DHEA(S) level in response to the DEX administration. We aimed to compare the post-DEX cortisol and DHEAS levels and the cortisol/DHEAS ratio between schizophrenia patients and healthy controls. Here we administered the DST to 43 patients with schizophrenia and 37 age-and sex-matched healthy controls. Plasma cortisol levels, serum DHEAS levels, and cortisol/DHEAS ratio after administration of 0.5 mg of DEX were compared between the two groups. Schizophrenia patients showed significantly higher cortisol level and cortisol/DHEAS ratio than controls, while DHEAS levels were not significantly different between groups. These results suggest that besides the cortisol level, cortisol/DHEAS ratio as assessed with the DST might reflect abnormal HPA axis function in schizophrenia.

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confidence: 71%

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Hori¹

2012

TONEUROPPJ

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“…This might be related to the drug treatments and energy balance, factors that can also influence neurotrophin functioning. 48 Venkatasubramanian et al found that antipsychotic-naive patients with schizophrenia had lower serum concentrations of IGF-1, which increased after the start of drug treatment. Two studies reported reductions in IGF-1 among patients taking clozapine 27,49 ; this phenomenon may have influenced the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

Silva

Cassilhas

Àttux

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. Methods: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables were assessed. Results: A significant time-by-group interaction was found for the RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, significant improvements on negative symptoms (p = 0.027), on the role-physical domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM test (p = 0.040) were observed in the RESEX group. No changes were observed for the other variables investigated. Conclusions: In this sample of patients with schizophrenia, 20 weeks of resistance or concurrent exercise program improved disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543.

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“…Decreased serum IGF-1 levels were considered to be strongly associated with the neurodevelopmental pathogenesis of schizophrenia [6,7]. In the present case, although her serum IGF-1 level was not examined during hospitalization, her elevated cortisol level at the time of admission improved to within normal ranges on the 34th day.…”

Section: Discussionmentioning

confidence: 53%

“…Its pathogenesis is considered to be associated with abnormal activity by the hypothalamic-pituitary-adrenal (HPA) axis. In addition, antipsychotic treatments for schizophrenia patients with hypercortisolism have been suggested to reduce high serum cortisol levels to within normal limits [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

A Case of Transient Hypercortisolism Simultaneously Occurring With the Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Olanzapine

et al. 2017

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We herein present a case of a 71-year-old woman who was referred to our hospital with the prolonged disturbance of consciousness after two convulsive seizures the day before admission. She was in longterm hospitalization because of schizophrenia. Blood tests showed severe low-osmolar hyponatremia (Osm: 226 mOsm/kg and Na: 110.3 mEq/L) and hypokalemia (K: 2.67 mEq/L). An endocrine examination revealed that the syndrome of inappropriate antidiuretic hormone secretion (SIADH), which was induced secondary to olanzapine, and transient hypercortisolism had simultaneously occurred. Low-and high-dose overnight dexamethasone suppression tests and the corticotropin-releasing hormone (CRH) test showed similar endocrine responses to those in patients with Cushing's syndrome. However, no abnormality in the pituitary gland was detected using contrast magnetic resonance imaging (MRI). After admission, elevated adrenocorticotropic hormone (ACTH) and cortisol levels gradually decreased and normalized by the time of discharge. Transient hypercortisolism sometimes occurs in patients with schizophrenia. Hypercortisolism in the present case was considered to be induced by stress such as severe hypo-osmotic hyponatremia and convulsions in addition to the underlying disorder of schizophrenia. Clinicians need to routinely check electrolytes in patients taking olanzapine in order to prevent insidious progression to severe hyponatremia. To the best of our knowledge, this is the first case report in which an endocrine examination and its interpretation were performed for SIADH accompanied by transient hypercortisolism due to the stimulation of ACTH.

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Effect of antipsychotic treatment on Insulin-like Growth Factor-1 and cortisol in schizophrenia: A longitudinal study

Cited by 75 publications

References 43 publications

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

A Case of Transient Hypercortisolism Simultaneously Occurring With the Syndrome of Inappropriate Antidiuretic Hormone Secretion Induced by Olanzapine

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