Effect of antioxidant/reducing agents on the initial and long-term bonding performance of a self-etch adhesive to caries-affected dentin with and without smear layer-deproteinizing

Prasansuttiporn, Taweesak; Thanatvarakorn, Ornnicha; Mamanee, Teerapong; Hosaka, Keiichi; Tagami, Junji; Foxton, Richard M.; Nakajima, Masatoshi

doi:10.1016/j.ijadhadh.2020.102648

Cited by 9 publications

(9 citation statements)

References 43 publications

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“…Previous studies demonstrated that the application of Accel significantly improved the bonding performance of 1-SEAs and 2-SEAs to normal and caries-affected dentin after the smear layer deproteinizing pretreatment [41][42][43][44][45] . Additionally, it was demonstrated that the pretreatment with Accel could improve the bonding durability of 2-SEAs to untreated as well as smear layer-deproteinized dentin 46,47) . Further research is required to examine the effect of sulfinate concentrations in the agent on the initial and long-term bond strengths and DC of 1-SEAs to untreated as well as smear layer-deproteinized dentin.…”

Section: Discussionmentioning

confidence: 99%

Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents

et al. 2021

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The influence of sulfinate agents applied as a dentin pretreatment or a mixture with multi-mode one-step self-etch adhesives (1-SEAs) on the degree of conversion (DC) and micro-tensile bond strength (μTBS) of light-cured 1-SEAs was investigated. 1-SEAs Clearfil Universal Bond Quick (UBQ) or Scotchbond Universal Adhesive (SBU) were applied to dentin in etch&rinse or self-etch mode using various application strategies: 1) no pretreatment, 2) pretreatment with 90 wt% ethanol, 3) pretreatment with a sulfinate agent Clearfil DC Activator (UDC) or Scotchbond Universal DCA (SDC), or 4) a mixture of UBQ+UDC or SBU+SDC. μTBS was measured after 24 h. Additionally, DC was measured using attenuated total reflectance Fourier-transform infrared spectroscopy. Pretreatment with sulfinate agents resulted in the highest μTBS and DC, significantly improving them especially in etch&rinse mode. The mixture of sulfinate agents with 1-SEAs was less effective. Pretreatment with ethanol significantly improved μTBS in etch&rinse mode but compromised μTBS in self-etch mode.

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Section: Discussionmentioning

confidence: 99%

Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents

et al. 2021

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Section: Discussionmentioning

confidence: 99%

“…As a part of the deproteinizing action of NaOCl, free radicals were formed, and they interfered with the propagation of vinyl radicals, which in turn resulted in premature chain termination and the incomplete polymerization of adhesives [21,[24][25][26][27]. This was the rationale for using STS, as previous studies showed that applying antioxidants or reducing agents could improve the bond strength to NaOCl-deproteinized dentin [21,[24][25][26][27]. Furthermore, sulfinates could substitute tertiary amines as co-initiators of camphorquinone [35], which is used as a photoinitiator in most adhesive systems, and sulfinate-containing agents were recently reported to increase the degree of conversion of light-cured adhesives on dentin [28].…”

Section: Discussionmentioning

confidence: 99%

“…However, previous reports have shown that the treatment of dentin with NaOCl harms the polymerization of adhesives, as the oxidizing effect leads to premature chain termination [21] and hampers the bonding performance [22]. The effect is dependent on the application time of NaOCl [23] and to counteract this, the application of an antioxidant, e.g., sodium ascorbate, sodium thiosulfate, rosmarinic acid or sodium p-toluenesulfinate (STS), was shown to be effective in several studies [21,[24][25][26][27]. Moreover, a recent study showed that the application of agents containing sulfinates improved the adhesives' degree of conversion even on untreated sound dentin [28].…”

Section: Introductionmentioning

confidence: 99%

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Sodium p-Toluenesulfinate Enhances the Bonding Durability of Universal Adhesives on Deproteinized Eroded Dentin

et al. 2021

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The effects of deproteinization using sodium hypochlorite (NaOCl) and the subsequent application of an antioxidant (sodium p-toluenesulfinate, STS) onto the bonding durability of universal adhesives on eroded dentin were investigated. Untreated sound dentin served as the control, whereas eroded dentin, which had been prepared by pH-cycling in 1% citric acid and a remineralization solution, was either untreated, deproteinized with a 10% NaOCl gel or deproteinized with the 10% NaOCl gel and subsequently treated with an STS-containing agent. The dentin surfaces were bonded using a universal adhesive (Clearfil Universal Bond Quick, Scotchbond Universal or G-Premio Bond), and the micro-tensile bond strength (µTBS) test was performed after 24 h or 10,000 thermal cycles. The µTBS data were statistically analyzed using a three-way ANOVA and Tukey’s HSD post hoc tests. The lowest µTBS was measured on untreated eroded dentin (p < 0.001). Deproteinization of eroded dentin resulted in µTBS similar to untreated sound dentin (p > 0.05), but the highest µTBS was obtained if deproteinization was followed by the application of STS. Thermocycling significantly decreased µTBS in all groups (p < 0.001), except for STS-treated deproteinized eroded dentin (p > 0.05). This indicated that deproteinization, followed by the application of STS, could enhance the bonding durability of universal adhesives on eroded dentin.

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“…It has recently been reported that the application of 6% sodium hypochlorite (NaOCl) or 50-200 ppm hypochlorous acid (HOCl) solutions can dissolve the organic phase of the smear layer, thus increasing the mineral-to-organic ratio on the bonding surface and thinning the smear layer [4][5][6][7][8][9][10] . In addition, when bonding with SEAs, the deproteinizing pretreatment of dentin surfaces covered with a smear layer can prevent the formation of the hybridized smear layer, and it significantly improves the bonding of SEAs to cariesaffected dentin, that is covered with a thicker and collagen-rich smear layer 4,6,8) .…”

Section: Introductionmentioning

confidence: 99%

Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?

et al. 2022

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This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a standardized smear layer were pretreated with 6% NaOCl or 100 ppm HOCl for 5 s, 15 s, or 30 s, and washed out with water for 5 s, 15 s or 30 s with or without the application of Clearfil DC Activator (CDA). No pretreatment was used as a control. The discs were bonded with a 1-SEA (Bond Force II or Clearfil Universal Bond Quick) and microtensile bond strength (µTBS) was measured after 24 h. Pretreatment with NaOCl for 15 s and 30 s significantly decreased µTBS (p<0.05), irrespective of wash-out time. The application of CDA recovered µTBS but did not outperform the control group. Conversely, pretreatment with HOCl for 15 s and 30 s followed by 30 s wash-out time significantly increased µTBS of 1-SEAs (p<0.05), regardless of CDA application.

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Effect of antioxidant/reducing agents on the initial and long-term bonding performance of a self-etch adhesive to caries-affected dentin with and without smear layer-deproteinizing

Cited by 9 publications

References 43 publications

Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents

Degree of conversion and dentin bond strength of light-cured multi-mode adhesives pretreated or mixed with sulfinate agents

Sodium p-Toluenesulfinate Enhances the Bonding Durability of Universal Adhesives on Deproteinized Eroded Dentin

Smear layer deproteinization with NaOCl and HOCl: Do application/wash-out times affect dentin bonding of one-step self-etch adhesives?

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