Effect of antioxidant lycopene on human osteoblasts

Bengi, V. Umut; Saygun, Işıl; Bal, Vehbi; Özcan, Erkan; Ozkan, C Kose; Torun, D; Avcu, Ferit; Kantarcı, Alpdoğan

doi:10.1007/s00784-022-04789-z

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Yoshihara et al, 2016(Yoshihara et al, 2016 found that serum osteocalcin had a significant positive association with periodontitis and studies such as that of Golijanin et al, 2015(Golijanin et al, 2015 showed that collagen density and volume decreased significantly as PD progressed. A recent study by Bengi et al, 2022(Bengi et al, 2023 assessed in vitro the proliferative effect of lycopene on human osteoblasts, concluding that its antioxidant effect, would influence as a proliferative stimulator of osteoblastic cells, resulting in a potent bone healing agent. Another recent review reported that lycopene is a potent antioxidant and anticarcinogen, due to the modification of certain pathways that trigger cell growth or death (Ozkan et al, 2023).…”

Section: General Discussion Of Resultsmentioning

confidence: 99%

“…A recent study by Bengi et al, 2022(Bengi et al, 2023 assessed in vitro the proliferative effect of lycopene on human osteoblasts, concluding that its antioxidant effect, would influence as a proliferative stimulator of osteoblastic cells, resulting in a potent bone healing agent. Another recent review reported that lycopene is a potent antioxidant and anticarcinogen, due to the modification of certain pathways that trigger cell growth or death (Ozkan et al, 2023).…”

Section: General Discussion Of Resultsmentioning

confidence: 99%

“…Precisely, this potent antioxidant action is associated with a lower risk of chronic diseases (Rao and Rao, 2007) and it has been shown that high concentrations of lycopene in serum, are associated with lipid peroxidation and a decrease in protein oxidation (Mackinnon et al, 2011). At the cellular level it has been shown that, lycopene, has proliferative effects on osteoblasts, increasing bone regeneration, as well as an inhibitory effect on osteoclastic formation and resorption, which could be very useful in tissue engineering, since lycopene could increase the quality and speed of new bone formation in periodontal treatments (Sołtysiak and Folwarczna, 2015;Bengi et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease

López-Valverde,

Macedo de Sousa

et al. 2024

Front. Bioeng. Biotechnol.

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This systematic review with meta-analysis evaluated the antioxidant effect of lycopene as an adjuvant treatment for periodontal disease. PubMed, EMBASE and Web of Science databases were consulted. According to the PICOs strategy, inclusion criteria were established for intervention studies Randomized Controlled Trials in Probing depth subjects (participants) treated with conventional treatment and lycopene (intervention) compared to patients treated with conventional treatment (control) in which periodontal response to treatment (outcome) was assessed. The risk of bias for randomized studies was assessed using the Cochrane Risk of Bias Tool. The methodological quality of the studies included in the meta-analysis was measured using the Jadad scale. Quantitative data were analyzed using six random-effects meta-analyses, taking into account periodontal parameters: Probing Pocket Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index, Uric Acid and Gingival Index. Six further meta-analyses were performed, according to the follow-up of the studies (short-, medium- and long-term). Of the 339 studies identified, only 7 met the eligibility criteria. The meta-analysis of the studies according to the parameters evaluated only obtained statistical significance in the assessment of plaque index (p = 0.003). Regarding follow-up periods, PPD was significant (p = 0.03) in the short term. bleeding on probing estimates were significant in the short and medium term (p = 0.008 and p = 0.03, respectively), IP was significant in the short and medium term (p = 0.0003 and p = 0.01, respectively) and gingival index in the short and medium term (p = 0.002 and p = 0.02, respectively). Heterogeneity was high (I2 >50%) in all assessments, except for Clinical Attachment Loss (I2 = 16.7%). The results demonstrate that antioxidant treatment with lycopene could be useful as an adjunctive treatment for periodontal disease.

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Section: General Discussion Of Resultsmentioning

confidence: 99%

Section: General Discussion Of Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease

López-Valverde,

Macedo de Sousa

et al. 2024

Front. Bioeng. Biotechnol.

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“…The proliferative effects of lycopene on the human osteoblast cell line (CRL-11372) were analyzed using an in vitro wound healing model. Lycopene had proliferative effects on human osteoblasts, as well as a helpful approach in tissue engineering procedures and periodontitis treatment [111]. In fact, the effect of lycopene on osteoblasts and osteoclasts was presented in the patent EP2948005, a therapeutic composition with anti-inflammatory activity.…”

Section: Other Compound-related Patents In Periodontal Diseasesmentioning

confidence: 99%

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

Juiz,

Ferreira,

Pires

et al. 2024

Antioxidants

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Periodontal disease is an inflammatory condition characterized by an aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing an essential role in its pathogenesis. This paper presents a patent mining, performed in the Orbit Intelligence patent database, related to antioxidant phytochemicals in the technological developments that are working to prevent and treat periodontal disease. To access the documents, the descriptors “PERIODONTAL” and “ANTIOXIDANT” were typed in the title, abstract, and claim search fields. A total of 322 patents demonstrate the growing interest in researching natural antioxidants for scientific and technological purposes. The top ten countries regarding the number of family patents produced were the United States, the European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, and Great Britain. The most cited compounds were vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, and curcumin. These compounds have been used for the technological development of gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, and mouth massage cream and exhibit the ability to neutralize free radicals and reduce oxidative stress, a critical factor in the development and progression of periodontal diseases. The patent documents have shown that using antioxidant compounds in conjunction with traditional periodontal treatments is a promising area of interest in periodontal therapy.

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“…Additionally, Bengi et al showed that in the human OB cell line (CRL-11372), lycopene exerts a proliferative effect [ 72 ]. In animal models, 10- or 20-mg/kg lycopene, which was administered once orally using an intragastric feeding tube, inhibited BMD decrease in OVX rats, and increased lumbar and femoral BMD, even if these differences did not reach the statistical significance.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

Faienza,

Giardinelli,

Annicchiarico

et al. 2024

IJMS

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Bone health is the result of a tightly regulated balance between bone modeling and bone remodeling, and alterations of these processes have been observed in several diseases both in adult and pediatric populations. The imbalance in bone remodeling can ultimately lead to osteoporosis, which is most often associated with aging, but contributing factors can already act during the developmental age, when over a third of bone mass is accumulated. The maintenance of an adequate bone mass is influenced by genetic and environmental factors, such as physical activity and diet, and particularly by an adequate intake of calcium and vitamin D. In addition, it has been claimed that the integration of specific nutraceuticals such as resveratrol, anthocyanins, isoflavones, lycopene, curcumin, lutein, and β-carotene and the intake of bioactive compounds from the diet such as honey, tea, dried plums, blueberry, and olive oil can be efficient strategies for bone loss prevention. Nutraceuticals and functional foods are largely used to provide medical or health benefits, but there is an urge to determine which products have adequate clinical evidence and a strong safety profile. The aim of this review is to explore the scientific and clinical evidence of the positive role of nutraceuticals and functional food in bone health, focusing both on molecular mechanisms and on real-world studies.

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Effect of antioxidant lycopene on human osteoblasts

Cited by 6 publications

References 27 publications

Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease

Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health

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