Abstract:The pharmacokinetics of acetaminophen in a group of healthy volunteers has been studied after a single peroral administration at a dose of 625 mg under normal and antiorthostatic hypokinesia (head-down bed rest) conditions. A highly significant correlation has been established between the concentrations of acetaminophen in the blood plasma and saliva of volunteers and also between the pharmacokinetic parameters calculated from the dynamics of drug distribution in plasma and saliva. A tendency toward increased … Show more
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