Effect of antihypertensive therapy on hospitalization and mortality among uncomplicated and high risk hypertensive patients

Abstract

and older (66.4 ± 11.6, 67.5 ± 13.2 VS 61.6 ± 13.9) than hypertensive patients and were more treated with concomitant therapy. Drugs acting on the renin-angiotensin system were the more frequent choice in the three cohorts but with a different prevalence (63.9%, 52.9%, 35.9% in diabetic, hypertensive and high risk patients respectively). Adherent patients to AHD (PDC > 80%) were 44.0% among diabetic patients, 48.4% among high risk, 35.2% among hypertensive. A Cox regression model showed that the risk of the combined outcome was determined by increasing age, male gender, presence of concomitant therapy, low adherence to AHD and first choice of AHD. Conclusions: An integrated analysis of prescription and hospital discharge database has the great advantage that it uses routinely available data, it can be done quickly and by few staff, and it is less expensive than planned large scale survey.