Effect of antihypertensive drugs on mortality, morbidity and blood pressure in blacks

Brewster, LLM; Kleijnen, J; Montfrans, GA van

doi:10.1002/14651858.cd005183

Cited by 3 publications

(4 citation statements)

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“…For comparison, a search for further retracted Cochrane reviews using the PubMed query “Cochrane Database Syst Rev[TA] AND Retracted Publication[PT] AND 1971:2005/5/25[edat]” was conducted. One reference, in addition to the IHCA review already discussed, was identified, which was a retracted review by Brewster et al [ 18 ] about antihypertensives. The retraction for the Brewster et al review is explained on the Cochrane website as follows: “This systematic review has been withdrawn temporarily because its contents are potentially misleading.”…”

Section: Resultsmentioning

confidence: 99%

A Case Study of a Retracted Systematic Review on Interactive Health Communication Applications: Impact on Media, Scientists, and Patients

Rada¹

2005

J Med Internet Res

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Background In October 2004, a flawed systematic review entitled “Interactive Health Communication Applications for People with Chronic Disease” was published in the Cochrane Library, accompanied by several press releases in which authors warned the public of the negative health consequences of interactive health communication applications, including the Internet. Within days of the review's publication, scientists identified major coding errors and other methodological problems that invalidated the principal conclusions of the study and led to a retraction. While the original study results and their negative conclusions were widely publicized in the media, the retraction seemed to go unnoticed.Objective This paper aims to document an unprecedented case of misinformation from a Cochrane review and its impact on media, scientists, and patients. As well, it aims to identify the generic factors leading to the incident and suggest remedies.Methods This was a qualitative study of the events leading to the retraction of the publication and of the reactions from media, scientists, and patients. This includes a review and content analysis of academic and mass media articles responding to the publication and retraction. Mass media articles were retrieved in May 2005 from LexisNexis Academic and Google and were classified and tallied. The extended case method is employed, and the analysis is also applied to comparable publishing events.Results A search on LexisNexis Academic database with the query “Elizabeth Murray AND health” for the period of June 2004 to May 2005 revealed a total of 15 press reports, of which only 1 addressed the retraction. Google was searched for references to the review, and the first 200 retrieved hits were analyzed. Of these, 170 pages were not related to the review. Of the remaining 30 pages, 23 (77%) were reports about the original publication that did not mention the retraction, 1 (3%) was a bibliography not mentioning the retraction, and 6 (20%) addressed the retraction, of which only 1 was a non-Cochrane–related source.Conclusions Analyzed retrievals showed that the mass media gave more coverage to the Cochrane review than to the retraction or to a related systematic review with a similar scope but a different conclusion. Questionable results were prematurely disseminated, oversimplified, and sensationalized, while the retraction was hardly noticed by the public. Open commentary by scientists and patients helped to rapidly identify the errors but did not prevent or correct the dissemination of misinformation.

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Section: Resultsmentioning

confidence: 99%

A Case Study of a Retracted Systematic Review on Interactive Health Communication Applications: Impact on Media, Scientists, and Patients

Rada¹

2005

J Med Internet Res

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“…Whilst much of the salutary effect of diuretics on stroke prevention might be related to the slightly lower BP achieved in the diuretic group, it would not fully account for the significantly greater reduction in stroke rates in Black patients receiving diuretics, compared with ACEIs [10]. Although this might be related to the poorer efficacy of ACEIs in Black patients, possibly related to genetic differences [11–14], it is also possible that some of the benefit seen with diuretics might be related to enhancement of angiotensin II (AngII).…”

Section: Introductionmentioning

confidence: 99%

Role of angiotensin receptor blockers in the prevention and management of ischaemic stroke

Mathur

Cleland

Rodrigues

et al. 2007

Euro J of Neurology

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“…Overall, 1 in 3 American adults have high blood pressure (BP), while 2 in 5 African American adults have high BP 2 . African Americans bear a greater burden of disease, 3,4 have a variable response to conventional antihypertensive medications, 5,6 and develop more severe end‐organ damage 7,8 …”

mentioning

confidence: 99%

“…1 Overall, 1 in 3 American adults have high blood pressure (BP), while 2 in 5 African American adults have high BP. 2 African Americans bear a greater burden of disease, 3,4 have a variable response to conventional antihypertensive medications, 5,6 and develop more severe end-organ damage. 7,8 In addition to pharmacologic therapy and lifestyle modifications, community-based interventions focusing on African Americans may improve outcomes.…”

mentioning

confidence: 99%

Antihypertensive Therapy in African Americans: Findings From an Inner‐City Ambulatory Clinic

Odigie-Okon

Zarich²,

Okon³

et al. 2010

J of Clinical Hypertension

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African Americans bear a greater burden of hypertension. Understanding prevailing epidemiologic patterns can facilitate the implementation and successful outcome of community programs. The authors assessed practice patterns of antihypertensive drug utilization and blood pressure (BP) control in a predominantly African American population in Brooklyn, NY, from January 1 to January 31, 2008. A total of 416 (53.1%) had hypertension, with a mean age of 61 years, and 267 (64%) were women. In general, 212 (50.9%) were at goal BP and 59.9% of those at goal were taking at least 2 drugs. Patient age correlated with the number of drugs used (r=0.14; P=.004). Patients taking b-blockers and calcium channel blockers were older: 63.6 vs 60.1 years (P=.01) and 62.7 vs 60.3 years (P=.07), respectively. The pattern of antihypertensive use was as follows:angiotensin-converting enzyme inhibitors, 194 (46.6%); calcium channel blockers, 162 (38.9%); diuretics, 162 (38.9%); b-blockers, 133(32%); and angiotensin receptor blockers, 93 (22.4%). The findings of age associated with the class of medications used and a predominance of angiotensin-converting enzyme inhibitors usage highlight possible gaps in appropriateness of antihypertensive therapy. The application of age-appropriate race-based antihypertensive therapy might improve BP control rates. These results strengthen arguments for investing in community-based programs to overcome possible provider-related and local health system barriers to achieving BP control goals.

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Effect of antihypertensive drugs on mortality, morbidity and blood pressure in blacks

Cited by 3 publications

References 0 publications

A Case Study of a Retracted Systematic Review on Interactive Health Communication Applications: Impact on Media, Scientists, and Patients

A Case Study of a Retracted Systematic Review on Interactive Health Communication Applications: Impact on Media, Scientists, and Patients

Role of angiotensin receptor blockers in the prevention and management of ischaemic stroke

Antihypertensive Therapy in African Americans: Findings From an Inner‐City Ambulatory Clinic

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