Effect of Antihypertensive Drugs on Uric Acid Metabolism in Patients with Hypertension: Cross-Sectional Cohort Study

Ueno, S.; Hamada, Toshihiro; Taniguchi, Shin‐ichi; Ohtani, Naoyuki; Miyazaki, Shigeru; Mizuta, Einosuke; Ohtahara, Akira; Oginö, Kazuhíde; Yoshïda, Akio; Kuwabara, Masanari; Yoshida, Kazuharu; Ninomiya, Haruaki; Kotake, Hiroshi; Taufiq, Fikri; Yamamoto, Kazuhide; Hisatome, Ichiro

doi:10.1055/s-0042-113183

Cited by 33 publications

(41 citation statements)

References 19 publications

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“…It is also advised to make urine pH alkaline to prevent formation of kidney stones. The patient should also be interviewed according to the ACR 2012 Checklist for other health problems that increase UA [ 4 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…In another study conducted by Ueno et al [ 22 ] 751 patients with AH were treated with diuretics, β-blockers or α-1 blockers. The eGFR in patients treated with these drugs was negatively correlated with UA level.…”

Section: Discussionmentioning

confidence: 99%

“…The drugs reduced eGFR and raised UA levels. Calcium channel blockers, ACE inhibitors and ARBs, including losartan, did not increase serum UA levels [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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What is the role of angiotensin receptor blockers in treatment of hyperuricemia coexisting with arterial hypertension?

Nieradko-Iwanicka

2018

Reumatologia

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Angiotensin receptor blockers or sartans are used to treat arterial hypertension. Hyperuricemia and arterial hypertension often coexist in patients with metabolic syndrome. Also hyperuricemia is correlated with an increased risk of cardiovascular disease and death. There are data suggesting that lowering serum urate may assist in control of arterial hypertension and use of certain drugs for arterial hypertension may reduce the serum uric acid level. The Polish Society of Arterial Hypertension recommends losartan for treatment of arterial hypertension in patients with coexisting hyperuricemia.The aim of the present review was to find evidence supporting the concept of use and explain the role of sartans in treatment of hyperuricemia.Thirty-five original and review articles about hyperuricemia and arterial hypertension focusing on the use of sartans in both these medical conditions were analyzed.In conclusion, sartans should be recommended for treatment of hyperuricemia coexisting with arterial hypertension in patients without bilateral renal artery stenosis and with exclusion of pregnant women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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What is the role of angiotensin receptor blockers in treatment of hyperuricemia coexisting with arterial hypertension?

Nieradko-Iwanicka

2018

Reumatologia

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“…Due to the fact that all patients who developed tachycardia while on second-line anti-TB drugs were taking propranolol (40mg once or twice daily for at least three months), incident gout could partially be attributed to the effect of this beta-blocker. This is because beta-blockers like propranolol are known to increase the amount of uric acid in blood [24–26], which is a predisposing factor for the development of gout. However, it is difficult to establish causation between tachycardia (through intake of propranolol) and gout from this study since it is unknown which event developed first.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Gout in MDR-TB Patients in Eritrea: A Case-Control Study

Russom

Tesfaselassie

Goitom

et al. 2019

Tuberculosis Research and Treatment

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Though the incidence of gout in general population is less than 5% (globally), a study conducted in Eritrea among patients with multidrug resistant tuberculosis (MDR-TB) revealed a higher incidence (25%). Other similar studies conducted elsewhere, however, did not report gout as an adverse effect. It is unknown why a higher incidence of gout is being reported in Eritrea compared to similar studies from other countries. The objective of this study is therefore to explore risk factors for the increased risk of incident gout among MDR-TB patients in Eritrea. A case-control study was conducted in Merhano MDR-TB National Referral Hospital in Eritrea. All MDR-TB patients diagnosed with gout between June 2011 and June 2018 were considered as cases. Controls matched by age, sex, and cumulative drug exposure time were selected from the same study population (1:1 ratio). A total of 84 MDR-TB patients, 42 cases and 42 controls, were included in this study. No patient from the control group has comorbidities, while six patients from the case group have diabetes (χ2 = 6.46, df=1, p=0.026). Patients having tachycardia (OR=3.26, 95% CI=1.28, 8.27), alopecia (OR=3.11, 95% CI=1.00, 9.67), and gastrointestinal upset (OR=3.17, 95% CI=1.26, 7.96) as adverse effects and being on prolonged use of propranolol (OR=3.26, 95% CI=1.28, 8.27) were found to be more likely to develop incident gout compared to their controls. In conclusion, MDR-TB patients with diabetes mellitus, tachycardia, alopecia, and gastrointestinal upset and on prolonged use of propranolol tablet had increased risk of incident gout.

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“…Nevertheless, allopurinol may also be considered in hypertensives with asymptomatic HU, particularly those at high CV risk. Among the drugs recommended for the treatment of co-morbidities with HU, great attention should be paid to the key drugs that influence sUA levels (Table 1) [153][154][155][156][157][158][159].…”

Section: Allopurinol and Hypertensionmentioning

confidence: 99%

Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk

Borghi¹,

Tykarski²,

Widecka³

et al. 2018

Cardiol J

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Effect of Antihypertensive Drugs on Uric Acid Metabolism in Patients with Hypertension: Cross-Sectional Cohort Study

Cited by 33 publications

References 19 publications

What is the role of angiotensin receptor blockers in treatment of hyperuricemia coexisting with arterial hypertension?

What is the role of angiotensin receptor blockers in treatment of hyperuricemia coexisting with arterial hypertension?

Risk Factors of Gout in MDR-TB Patients in Eritrea: A Case-Control Study

Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk

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