Effect of Antihypertensive Agents on Biochemical Parameters in Diabetic Patients in Taif - KSA

Abstract

Introduction: Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Our objective is to evaluate the effect of Angiotensin converting enzyme inhibitors and Angiotensin II receptor blockers comparatively and in integration with Metformin, dipeptidyl 4 inhibitors and insulin on lipid profile, serum creatinine, liver enzymes and electrolytes in type II diabetic patients.Methodology: Data of the study were collected from clinical reports of 100 hypertensive patients with type II diabetes from Taif Diabetic Center. Male and non-pregnant female with an average age (55 ± 10 years) who's treated with ACE Inhibitors and ARBs were our target.Results: Our results recorded that, ARBs significantly increase AST in compared to ACE inhibitors while chloride level decrease with ACE inhibitors in compared to ARBs.On other hand, when we compared the effect of ACE/ARBs in combined with antidiabetic agents Significant increase in TC was recorded with ACE inhibitors + Metformin, also LDL was increase with ACE inhibitors + insulin while ARBs + Insulin was increase HDL. Serum creatinine increased in both groups used Insulin. ALT was significantly increases with ARBs + Metformin + DPP-4 inhibitors.Electrolytes were affected during the combination with antidiabetic agents, Sodium level was increased with ARBs + Metformin + DPP4 inhibitors and potassium was increase with ARBs + Insulin. Conclusion:There are slight effects on selected biochemical parameters was recorded during the treatment with ACE inhibitors and ARBs separately and when combined with antidiabetic agents.