Effect of antiglaucoma agents on short-term intraocular pressure fluctuations after intravitreal bevacizumab injections

Shoeibi, Nasser; Ghosi, Zina; Habib, Jafari; Omidtabrizi, Arash

doi:10.1007/s10792-020-01667-z

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Lam et al [18] reported that history of glaucoma surgery reduced immediate IOP increase after intravitreal anti-VEGF agent injection and recovery time of IOP to baseline was short. Furthermore, Shoeibi et al [11] reported that administration of timolol, brimonidine, oral acetazolamide, and intravenous mannitol 30-60min before intravitreal bevacizumab injection did not reduce the immediate IOP increase. VR reduces immediate IOP increase [9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Shoeibi et al [11] reported that administration of timolol, brimonidine, oral acetazolamide, and intravenous mannitol 30-60min before intravitreal bevacizumab injection did not reduce the immediate IOP increase. VR reduces immediate IOP increase [9][10][11] . Chen et al [24] reported that VR might be a potential cause of endophthalmitis after intravitreal injection and its visual outcome is poor [25] .…”

Section: Discussionmentioning

confidence: 99%

“…Vitreous reflux (VR) is frequently observed after intravitreal anti-VEGF antibody injection. VR ameliorates the immediate IOP increase [9][10][11] . Uyar et al [9] reported that VR rate decreased as the total number of intravitreal ranibizumab injection increased.…”

Section: Introductionmentioning

confidence: 94%

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Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

Muto,

Imaizumi

2024

Int J Ophthalmol

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AIM: To evaluate the effect of background diseases and number of previous intravitreal aflibercept injections (IVAIs) on immediate intraocular pressure (IOP) increase and vitreous reflux (VR) rate and to evaluate the correlation of both age and axial length with immediate IOP increase and VR rate. METHODS: This study included 105 patients with cystoid macular edema secondary to retinal vein occlusion, 35 patients with diabetic macular edema, 69 patients with neovascular age-related macular degeneration (nAMD), and 12 patients with myopic choroidal neovascularization, which underwent first-time IVAI. The correlation of immediate IOP increase and VR rates with the four background diseases was investigated. Moreover, the correlation of age with immediate IOP increase and VR rate as well as correlation of axial length with immediate IOP increase and VR rate were evaluated. Further, 54 patients with nAMD were treated with IVAI>10 times (multiple IVAIs). Moreover, the correlation of immediate IOP increase and VR rates with first-time and multiple IVAIs in nAMD was determined. RESULTS: The immediate IOP increase (P=0.16) and VR rates (P=0.50) were almost similar among the four background diseases. The immediate postinjection IOP and age, VR rate and age, immediate postinjection IOP and axial length, or VR rate and axial length were not correlated in the four background diseases. The immediate IOP increase (P=0.66) and VR rates (P=0.28) did not significantly differ between first-time and multiple IVAIs in nAMD. CONCLUSION: Background diseases and number of previous IVAIs have no effect on immediate IOP increase and VR rate. Further, age and axial length have no correlation on immediate IOP increase and VR rate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

Muto,

Imaizumi

2024

Int J Ophthalmol

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“…Secondly, they checked the effect of IOP-decreasing drugs on after-injection IOP rise and found no pressurelowering effect of these prophylactic medications. 16 Knecht PB, et al used two techniques for intravitreal injection. One, with the straight entry of the needle and the second with the tunnelled entry of the needle.…”

Section: Discussionmentioning

confidence: 99%

Association Of Conjunctival Vitreous Reflux With Intraocular Pressure Spikes After Intravitreal Bevacizumab Injection

Abbasi,

Jameel,

Khan

et al. 2024

JRMC

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Objective: To evaluate the effect of conjunctival vitreous reflux on intraocular pressure immediately after intravitreal bevacizumab injection. Methods: A prospective interventional study was done at Benazir Bhutto Hospital, for 6 months from 13-01-2021 to 12-07-2021.Patients were selected through a non-probability consecutive sampling technique. A total of 88 eyes undergoing intravitreal bevacizumab were included in the study. IOP was checked before injection, immediately after injection, at 30 minutes and 60 minutes. The presence or absence of conjunctival reflux was noted. Data was analyzed to see the association of post-injection IOP and conjunctival reflux. Results: Those having conjunctival reflux positive had mean Intraocular pressure before intravitreal injection 13.14+2.569, the p-value was 0.0001. Immediately after injection at 0 minutes it was 27.95+3.988, and the p value was 0.0001. At 30 minutes, it was reduced to 21.58+2.814, the p-value was 0.0001, and at 60 minutes, the mean intraocular pressure was 17.26+1.853, and the p-value was 0.001. Those having conjunctival reflux negative had mean Intraocular pressure before intravitreal injection 13.44+2.981, p-value 0.0001. Immediately after injection at 0 minutes it was 33.69+5.608, and the p-value was 0.0001. At 30 minutes, it was reduced to 24.51+5.337, the p-value was 0.0001, and at 60 minutes, the mean intraocular pressure was 18.98+2.973, and the p-value was 0.001. Conclusion: Patients with vitreous reflux positive had less IOP elevation as compared to those with vitreous reflux negative. Keywords: Intravitreal bevacizumab injection, Intraocular pressure, conjunctival reflux.

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Prophylactic effect of brinzolamide–brimonidine fixed combination on intraocular pressure spikes after intravitreal anti-VEGF injections

et al. 2021

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Effect of antiglaucoma agents on short-term intraocular pressure fluctuations after intravitreal bevacizumab injections

Cited by 6 publications

References 33 publications

Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

Background diseases and the number of previous intravitreal aflibercept injections on immediate intraocular pressure increase and vitreous reflux rate in phakic eyes

Association Of Conjunctival Vitreous Reflux With Intraocular Pressure Spikes After Intravitreal Bevacizumab Injection

Prophylactic effect of brinzolamide–brimonidine fixed combination on intraocular pressure spikes after intravitreal anti-VEGF injections

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