Effect of antiepileptic drugs on liver enzymes

Hussein, Raghda R. S.; Soliman, Rabie; Ali, Ahmed Mahmoud Abdelhaleem; Tawfeik, Mona H.; Abdelrahim, Mohamed

doi:10.1016/j.bjbas.2013.09.002

Cited by 38 publications

(31 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bile duct proliferation was observed. The histopathological changes in the liver of rats exposed to sodium valproate agree with those published by Hussein et al (2013) who reported that a single dose of 62.5 mg/kg of cypermethrin administered orally to adult Albino rats produced necrotic areas in hepatocytes and cell swelling, cytoplasmic hypertrophy and intracytoplasmic vacuoles were seen.…”

Section: Discussionsupporting

confidence: 89%

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

Dalia¹,

Marwa²,

Walaa³

et al. 2018

J. Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Sodium valproate (VPA) used in epilepsy and has hepatotoxic effect in mammals. This work is to assess the role of L-arginin and omega-3 fatty acid against VPA oxidative stress on liver. This study was carried out on 70 rats divided into 7 groups each of 10 rats treated orally once daily 6days/ week; Group I (control), Group II (L-arginin): each rat was received 300 mg/kg L-arginin, Group III (omega-3): each rat received 300 mg/kg omega-3, Group IV (VIA): Each rat received 400 mg/kg VPA. Group V (VPA and L-arginin): Each rat received the previous doses. Group VI (VPA and omega-3): as before. Group VII (VPA, L-arginin and omega-3 group): as before. There was a significant increase in the mean values of AST, ALT, ALP and TBL in VPA treated group. Upon supplementation with L-arginin or omega-3 to VPA treated rats there was a significant decrease in the mean values of AST, ALT, ALP and TBL. Microscopic examination of liver section of VPA treated rat revealed vacuolated hepatocytes, focal necrosis, and enlarged portal tract. VPA toxicity induced severe liver damage in rats, and administration of either L-arginin or omega-3 protecting liver tissues.

show abstract

Section: Discussionsupporting

confidence: 89%

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

Dalia¹,

Marwa²,

Walaa³

et al. 2018

J. Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

show abstract

“…But long term administration of phenytoin is considered to affect thyroid profile. This is mainly thought to be through increasing clearance from the system by induction of hepatic enzymes 2 . Some authors have linked it with development of autoimmune thyroiditis 3 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

Long term administration of antiepileptic drugs has been found associated with development of hypothyroidism. But conflicting reports about effect on thyroid stimulating hormone (TSH) are available in literature and duration required to bring about this effect has also not been reported. Therefore, twenty five newly diagnosed adult patients with epilepsy were subjected to estimation of TSH before starting phenytoin and then at 2 and 6 months of phenytoin therapy. Phenytoin levels were also estimated using high performance liquid chromatography at 2 and 6 months and correlated with levels of TSH. The levels of TSH at 2 months of phenytoin therapy were found to be significantly increased as compared to baseline levels (p=0.000) and at 6 months (p=0.021) as compared to the levels at 2 months. A significant positive correlation was observed between the levels of phenytoin and TSH at 6 months (r=0.807, p=0.000) while the correlation was not found to be significant at 2 months duration. Thus, it may be concluded that there is a risk of development of hypothyroidism even at 2 months of phenytoin therapy in patients with epilepsy and should be monitored accordingly.

show abstract

“…Two additional compounds that could affect the tissue anti-oxidant status as a consequence of metabolism are terbinafine, an allylamine derivative used as an antifungal agent, and carbamazepine, an iminostilbene used for seizures. Both drugs likely generate reactive metabolites because hepatotoxicity, detectable by increases in serum transaminases, is associated with hypersensitivity or an immunological response in some individuals, yet evidence for adduct formation has not been reported [29,30,47,48]. …”

Section: Discussionmentioning

confidence: 99%

Liver Effects of Clinical Drugs Differentiated in Human Liver Slices

Vickers¹,

Ulyanov

Fisher³

2017

IJMS

View full text Add to dashboard Cite

Drugs with clinical adverse effects are compared in an ex vivo 3-dimensional multi-cellular human liver slice model. Functional markers of oxidative stress and mitochondrial function, glutathione GSH and ATP levels, were affected by acetaminophen (APAP, 1 mM), diclofenac (DCF, 1 mM) and etomoxir (ETM, 100 µM). Drugs targeting mitochondria more than GSH were dantrolene (DTL, 10 µM) and cyclosporin A (CSA, 10 µM), while GSH was affected more than ATP by methimazole (MMI, 500 µM), terbinafine (TBF, 100 µM), and carbamazepine (CBZ 100 µM). Oxidative stress genes were affected by TBF (18%), CBZ, APAP, and ETM (12%-11%), and mitochondrial genes were altered by CBZ, APAP, MMI, and ETM (8%-6%). Apoptosis genes were affected by DCF (14%), while apoptosis plus necrosis were altered by APAP and ETM (15%). Activation of oxidative stress, mitochondrial energy, heat shock, ER stress, apoptosis, necrosis, DNA damage, immune and inflammation genes ranked CSA (75%), ETM (66%), DCF, TBF, MMI (61%-60%), APAP, CBZ (57%-56%), and DTL (48%). Gene changes in fatty acid metabolism, cholestasis, immune and inflammation were affected by DTL (51%), CBZ and ETM (44%-43%), APAP and DCF (40%-38%), MMI, TBF and CSA (37%-35%). This model advances multiple dosing in a human ex vivo model, plus functional markers and gene profile markers of drug induced human liver side-effects.

show abstract

Effect of antiepileptic drugs on liver enzymes

Cited by 38 publications

References 31 publications

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

The amelorative effect of L-arginin and omega-3 fatty acid against sodium valproate induced hepatotoxicity

Untitled

Liver Effects of Clinical Drugs Differentiated in Human Liver Slices

Contact Info

Product

Resources

About