Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients

Mück‐Šeler, Dorotea; Jakovljević, Miro; Deanović, Z

doi:10.1016/0165-0327(91)90028-q

Cited by 44 publications

(15 citation statements)

References 34 publications

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“…We have found, for the first time, that the platelet 5-HT content was decreased in a large group of HD patients, regardless of the presence of comorbid depression, as compared with healthy controls or depressed psychiatric patients. The finding of the unaltered platelet 5-HT values between HD patients, with or without comorbid depression, is in line with the lack of any difference in platelet 5-HT levels between depressed patients and healthy controls [present study13, 14, 19, 20]. The presence of comorbid depression did not change already diminished platelet 5-HT concentrations, presumably a consequence of the impaired peripheral 5-HT function [2, 10, 11, 12]induced by the stress of the HD procedure [3, 4].…”

Section: Discussionsupporting

confidence: 70%

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Comorbid Depression and Platelet Serotonin in Hemodialysis Patients

Barišić

Pivac²,

Mück‐Šeler³

et al. 2004

Nephron Clin Pract

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Background/Aim: Comorbid depression often occurs in chronic renal failure patients on hemodialysis (HD). Reduced serotonin (5-HT) function is implicated in the pathophysiology of depression. Methods: Comorbid depression and different clusters of depressive symptoms were assessed in 79 male HD patients and 35 male depressed psychiatric patients. Platelet 5-HT concentration (a peripheral model for the central serotonergic neurons) was determined in all patients and 80 male healthy controls. Results: Comorbid depression occurred in 50 out of 79 HD patients. Depressed psychiatric patients and depressed HD patients had higher scores of anxiety, retardation, and cognitive symptoms than nondepressed HD patients. Platelet 5-HT concentration was lower in depressed or nondepressed HD patients than in healthy controls, or in depressed patients. Higher platelet 5-HT content was found in depressed psychiatric patients with depressive clusters than in all other patients. Among HD patients, anxious HD patients had a higher platelet 5-HT concentration than HD patients without anxiety symptoms. Conclusions: Comorbid depression occurred in 63% of HD patients. Dialyzed patients had decreased platelet 5-HT concentration, regardless of the occurrence of comorbid depression. Higher platelet 5-HT concentration was related to anxiety symptoms in HD patients. Our data suggest that platelet 5-HT concentration might be a suitable marker for anxiety symptoms in dialyzed patients.

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Section: Discussionsupporting

confidence: 70%

“…Blood (4 ml) was drawn from antecubital vein in a plastic syringe into 1 ml of acid citrate dextrose anticoagulant. Platelet 5-HT concentration was determined by the spectrofluorimetric method, as described before [13, 14, 19]. …”

Section: Methodsmentioning

confidence: 99%

Comorbid Depression and Platelet Serotonin in Hemodialysis Patients

Barišić

Pivac²,

Mück‐Šeler³

et al. 2004

Nephron Clin Pract

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“…Wirz-Justice and Puhringer (1978a) have found an in crease in bipolar patients without alteration in absolute platelet 5-HT levels from unipolar patients, and those results were later replicated by Stahl et al (1983). Moreover, the study from Muck-SeIer et al (1991) was also at variance with the reduced platelet 5-HT level in endogenous depression (Muck-SeIer et al 1991). These authors reported a hyperserotonemia in major depres sion.…”

Section: Discussionmentioning

confidence: 99%

“…Very few studies have examined depression-asso ciated changes in platelet 5-HT levels, and investiga tions in this domain have mostly yielded contradictory results (Lingjaerde 1979). For example, Muck-SeIer et al (1991) have recently reported a hyperserotonemia in unipolar depressed patients, whereas Quintana (1992) found a decreased platelet 5-HT content in ma jor depressed patients. The same author also reported an increase of platelet 5-HT concentrations following imipramine treatment, whereas previous papers had often reported that imipramine or other tricyclics (Mar tensson et al 1991;Celada et al 1992) induced platelet 0893-133X/94/$7.00 5-HT depletion, whatever the clinical outcome.…”

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confidence: 99%

Platelet Serotonin and Plasma Tryptophan in Depressed Patients: Effect of Drug Treatment and Clinical Outcome

Karege

Widmer

Bovier

et al. 1994

Neuropsychopharmacol

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Platelet serotonin and plasma tryptophan were studied in healthy subjects and in depressed patients before and during their antidepressant drug treatment. Before treatment, mean platelet serotonin level was normal in depressed patients compared with healthy subjects while a significant decrease in patients' plasma TRP was noted (t = 6.0, P < .001). anxiety scores. Antidepressant drugs treatment decreased platelet 5-HT level (ANOVA F = B.27, P < .001) whatever the clinical outcome of the patient, whereas the changes observed in plasma TRP were positively related to the mood state change. These results suggest that platelet serotonin could be a good pharmacological model but has no relevance concerning the mood state.

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“…In studies performed in human beings all SSRIs have consistently shown a drastic decrease in platelet serotonin content after several weeks of treatment reaching levels around or below 10% of the pretreatment serotonin levels (Wagner et al 1990;Mück-Seler et al 1991;Narayan et al 1998;Hergovich et al 2000;Javors et al 2000) (fig. 1).…”

Section: Pharmacology Of Ssris On Platelets and The Biological Plausimentioning

confidence: 99%