Effect of Antibodies to Nerve Growth Factor and Serum Albumin on the Development and Behavior of Mice

Abstract

We studied physical development, behavioral characteristics, and learning capacity in the offspring of mice immunized with nerve growth factor and bovine serum albumin. High titer of antibodies to these factors in the blood of pregnant females determines high levels of these antibodies in the blood of their pups. These changes modulate physical development, behavior, and learning capacity of rat pups. The effects of these antibodies differed in the strength and directionality. Antibodies to nerve growth factor more markedly retarded physical development, reduced learning capacity, and considerably increased pain thresholds in animals.

Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

“…In studies with experimental animals, it was noted that autoantibodies binding neuroantigens in the early stages of ontogenesis contribute to the formation of various structural anomalies in the nervous system and subsequently lead to a violation of the behavior of young animals. Thus, a high level of antibodies to nerve growth factor in the blood of pregnant females has a pronounced inhibitory effect on the learning process and significantly increases the threshold of pain sensitivity in the offspring [ 8 , 56 , 57 ]. Considering the data on the penetration of immunoglobulins through the blood-brain barrier in autoimmune disorders [ 58 , 59 ] and the detected BBB hyperpermeability in schizophrenia [ 60 ], this phenomenon can be explained by the fact that MBP stimulates the synthesis of antibodies to myelin components.…”