Effect of antibiotics on the expression of pyocyanin synthetic genes in Pseudomonas aeruginosa isolated from different clinical sources of a few hospitals in Mosul, Iraq
Rayan Mazin Faisal,
Rafal Mhaide Younis
Abstract:Pyocyanin is a blue-green phenazine pigment and one of the most virulent factors produced by the opportunistic pathogen Pseudomonas aeruginosa. It has a redox activity and a toxic impact on living cells, as it interacts with oxygen to produce reactive oxygen species (ROS). Using antibiotics at a sub-lethal dose has an unexpected influence on the expression of pyocyanin-producing genes. In this study, qPCR technique was performed to identify the effect of eight antibiotics (cefotaxime, ampicillin, amoxiclav, ce… Show more
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