Effect of Anti-Carbonic Anhydrase Antibodies on Carbonic Anhydrases I and II

Botrè, Francesco; Botrê, Claudio; Podestà, Elisabetta; Podda, Mauro; Invernizzi, Pietro

doi:10.1373/49.7.1221

Cited by 23 publications

(11 citation statements)

References 21 publications

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“…CA is responsible for bicarbonate reabsorption in the kidneys, NH + 4 excretion and the acid-base balance [ 2 ]. The inhibition of CA II by autoantibodies has been demonstrated [ 27 ]. In addition, autoantibodies are known to be taken up into target cells via receptor-mediated (Fc receptor) and nonreceptor paths (electrostatic interactions and endocytosis) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Carbonic Anhydrase II Antibodies in End-Stage Renal Disease Patients

Alver¹,

Menteşe

Menteşe³

et al. 2014

Med Princ Pract

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Objective: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. Subjects and Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. Results: The CA II autoantibody titers in the ESRD group (0.170 ± 0.237) were significantly higher than those in the control group (0.079 ± 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p < 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r = -0.278, p = 0.032, respectively). Conclusions: In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD.

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Section: Discussionmentioning

confidence: 99%

Anti-Carbonic Anhydrase II Antibodies in End-Stage Renal Disease Patients

Alver¹,

Menteşe

Menteşe³

et al. 2014

Med Princ Pract

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“…The presence of CA autoantibodies has been documented in acute anterior uveitis, Graves’ disease, systemic lupus erythematosus, Sjögren’s syndrome, endometriosis, idiopathic chronic pancreatitis, primary biliary cirrhosis, tubulointerstitial nephritis, autoimmune hepatitis, and autoimmune cholangitis. 17,18,19,20,21,24,25,26,27 …”

Section: Discussionmentioning

confidence: 99%

“…17,18,19,20,21 Based on this premise, the aim of our study was to investigate the presence of CA autoantibodies in patients with type 1 diabetes, which is considered an immunological disease, and to examine possible associations between these autoantibodies and DRP.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Serum Carbonic Anhydrase 1-2 Autoantibody Levels and Diabetic Retinopathy in Type 1 Diabetes Patients

Türk

Mollamehmetoğlu

Alver

et al. 2017

tjo

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Objectives:To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes.Materials and Methods:A total of 37 type-1 diabetic patients, 17 with DRP (group 1) and 20 without (group 2), and 38 healthy control subjects (group 3) were included. CA-I and CA-II autoantibody levels were measured in serum samples obtained from each of the three groups and compared statistically. Additionally, the correlation between CA-I and CA-II autoantibody levels and the presence of diabetic macular edema was examined.Results:Mean measured CA-I autoantibody levels were 0.145±0.072, 0.117±0.047, and 0.138±0.061 ABSU in group 1, group 2, and group 3, respectively (p=0.327). The average CA-II autoantibody levels achieved in the same groups were 0.253±0.174, 0.155±0.137, and 0.131±0.085 ABSU, respectively (p=0.005). No significant difference was obtained between the subgroups of group 1, with macular edema (n=8) and without (n=9), in terms of both CA-I and CA-II autoantibody levels (p=0.501, p=0.178, respectively).Conclusion:A significant correlation was observed between the development of DRP and serum CA-II autoantibody levels in type 1 diabetic cases. However, there was no correlation between the autoantibody levels and the presence of diabetic macular edema in cases with DRP.

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“…Indeed, CA II is a cytoplasmic enzyme, which is the most widespread of all CA isozymes and the catalytically fastest member of the a-class family (together with CA IX) and thus implicated in numerous physiological functions. To get further insights into various pathologies implicating CA II in autoimmune reactions 56 or deficiency 57 , it makes no doubt that specific hCA II inhibitors are needed and should be welcome for further advances in these fields. …”

Section: Discussionmentioning

confidence: 99%