Effect of anthocyanidins on myogenic differentiation in induced and non-induced primary myoblasts from rainbow trout ( Oncorhynchus mykiss )

Villasante, Alejandro; Powell, Madison S.; Murdoch, Gordon K.; Overturf, Ken; Cain, Kenneth D.; Wacyk, Jurij; Hardy, Ronald W.

doi:10.1016/j.cbpb.2016.03.004

Cited by 3 publications

(2 citation statements)

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“…Moreover, given the crosstalk among signaling pathways controlling muscle growth 44,45 , the redox status could also regulate the expression or activity of factors related to myogenesis, such as MRFs. A relatively recent study showed the effects of other antioxidants on primary myogenic cells isolated from skeletal muscle of rainbow trout, testing different doses of anthocyanidins 46 . The anthocyanidins upregulated the expression of gpx1 ( glutathione peroxidase 1 ) and pax7 ( paired box protein 7 ), which contribute to enhancing muscle tissue defense against oxidative stress and delay the progress of myogenic differentiation, respectively 46 , maintaining the cells in a quiescent or proliferative state.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid stimulates the in vitro myoblast proliferation and migration of pacu (Piaractus mesopotamicus)

Duran

Góes

Zanella

et al. 2019

Sci Rep

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The postembryonic growth of skeletal muscle in teleost fish involves myoblast proliferation, migration and differentiation, encompassing the main events of embryonic myogenesis. Ascorbic acid plays important cellular and biochemical roles as an antioxidant and contributes to the proper collagen biosynthesis necessary for the structure of connective and bone tissues. However, whether ascorbic acid can directly influence the mechanisms of fish myogenesis and skeletal muscle growth remains unclear. The aim of our work was to evaluate the effects of ascorbic acid supplementation on the in vitro myoblast proliferation and migration of pacu (Piaractus mesopotamicus). To provide insight into the potential antioxidant role of ascorbic acid, we also treated myoblasts in vitro with menadione, which is a powerful oxidant. Our results show that ascorbic acid-supplemented myoblasts exhibit increased proliferation and migration and are protected against the oxidative stress caused by menadione. In addition, ascorbic acid increased the activity of the antioxidant enzyme superoxide dismutase and the expression of myog and mtor, which are molecular markers related to skeletal muscle myogenesis and protein synthesis, respectively. This work reveals a direct influence of ascorbic acid on the mechanisms of pacu myogenesis and highlights the potential use of ascorbic acid for stimulating fish skeletal muscle growth.

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Section: Discussionmentioning

confidence: 99%

Ascorbic acid stimulates the in vitro myoblast proliferation and migration of pacu (Piaractus mesopotamicus)

Duran

Góes

Zanella

et al. 2019

Sci Rep

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“…Metformin is known to develop gastrointestinal side effects; rosiglitazone increases the cardiovascular risk (Nissen & Wolski, 2007) and pioglitazone increases the risk of bladder cancer (Lewis et al, 2011). Hydroxycinnamic acid derivatives (chlorogenic acid, p-coumaric acid, cinnamic acid, caffeic acid, trans-ferulic acid, and eugenol) are phenolic phytochemicals that have drawn considerable interest from pharmacological and food industries due to their various antioxidant and pharmacological properties, and their potential role in reducing the risk of several degenerative diseases with no side effects (Martineau et al, 2010;Villasante et al, 2016;Wiesner et al, 2001). Most importantly these derivatives are widely distributed in the plant kingdom and are mainly present in human dietary sources such as wheat, oat, rice, coffee seed, artichoke, pineapple, peanut, and bamboo shoot (Kumar & Pruthi, 2014;Liu, 2004).…”

Section: Introductionmentioning

confidence: 99%

trans‐ferulic acid attenuates hyperglycemia‐induced oxidative stress and modulates glucose metabolism by activating AMPK signaling pathway in vitro

Singh

Patil

2022

Journal of Food Biochemistry

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Adenosine monophosphate-activated protein kinase (AMPK) is a potent metabolic regulator and an attractive target for antidiabetic activators. Here we report for the first that, trans-ferulic acid (TFA) is a potent dietary bioactive molecule of hydroxycinnamic acid derivative for the activation of AMPK with a maximum increase in phosphorylation (2.71/2.67 ± 0.10; p < .001 vs. high glucose [HG] control) in hyperglycemia-induced human liver cells (HepG2) and rat skeletal muscle cells (L6), where HG suppresses the AMPK pathway. It was also observed that TFA increased activation of AMPK in a doseand time-dependent manner and also increased the phosphorylation of acetyl-CoA carboxylase (ACC), suggesting that it may promotes fatty acid oxidation; however, pretreatment with compound C reversed the effect. In addition, TFA reduced the level of intracellular reactive oxygen species (ROS) and nitric oxide (NO) induced by hyperglycemia and subsequently increased the level of glutathione. Interestingly, TFA also upregulated the glucose transporters, GLUT2 and GLUT4, and inhibited c-Jun N-terminal protein kinase (JNK1/2) by decreasing the phosphorylation level in tested cells under HG condition. Our studies provide critical insights into the mechanism of action of TFA as a potential natural activator of AMPK under hyperglycemia. Practical applicationsHydroxycinnamic acid derivatives possess various pharmacological properties and are found to be one of the most ubiquitous groups of plant metabolites in almost all dietary sources. However, the tissue-specific role and its mechanism under hyperglycemic condition remain largely unknown. The present study showed that TFA is a potent activator of AMPK under HG condition and it could be used as a therapeutic agent against hyperglycemia in type 2 diabetes.

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4-hydroxy-3-methoxy cinnamic acid accelerate myoblasts differentiation on C2C12 mouse skeletal muscle cells via AKT and ERK 1/2 activation

et al. 2019

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Effect of anthocyanidins on myogenic differentiation in induced and non-induced primary myoblasts from rainbow trout ( Oncorhynchus mykiss )

Cited by 3 publications

References 44 publications

Ascorbic acid stimulates the in vitro myoblast proliferation and migration of pacu (Piaractus mesopotamicus)

Ascorbic acid stimulates the in vitro myoblast proliferation and migration of pacu (Piaractus mesopotamicus)

trans‐ferulic acid attenuates hyperglycemia‐induced oxidative stress and modulates glucose metabolism by activating AMPK signaling pathway in vitro

4-hydroxy-3-methoxy cinnamic acid accelerate myoblasts differentiation on C2C12 mouse skeletal muscle cells via AKT and ERK 1/2 activation

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