Effect of antepartum vitamin D3 (cholecalciferol) and postpartum oral calcium administration on serum total calcium concentration in Holstein cows fed an acidogenic diet in late gestation

Hajikolaei, Mohammad Rahim Haji; Nouri, Mohammad; Amirabadi, Soroush Hassanpour; Shariari, Ali; Constable, Peter D.

doi:10.1016/j.rvsc.2021.02.017

Cited by 1 publication

(3 citation statements)

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“…The definitions of clinical diseases in the included studies are not consistent. Clinical hypocalcemia is defined as lying flat within 24 h after delivery, corrected by intravenous injection of calcium, or as the symptoms of lying weak or cold limbs without signs of physical injury within 72 h after delivery ( 28 , 29 ). Subclinical hypocalcemia is defined as serum Ca ≤ 2.12 mmol/L, or blood total Ca < 2.125 mM, or ≤ 1.00 mmol/L on calving day ( 23 , 35 , 38 ).…”

Section: Resultsmentioning

confidence: 99%

“…Displacement of the abomasum is defined as the decrease of milk production, and at the same time, when tapping and auscultating the left or right abdominal wall between the ninth and twelfth rib spaces, high-pitched tympanic resonance can be heard, with or without colic ( 24 ). Retained placenta is defined as the fetal membranes or placenta were not discharged within 24 h after delivery ( 28 , 29 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…At present, most farms use the commercial product Ca bolus as a supplement, and its main components are CaCl 2 and CaSO 4 . In addition, there are other forms of calcium supplements, such as Ca gel, Ca tubes and Ca fluid preparation (8,(24)(25)(26)(27)(28)(29)(30)(31). Although Valldecabres et al conducted a meta-analysis, it was revealed that oral Ca supplements were not associated with milk yield or pregnancy rate at first service (32).…”

Section: Introductionmentioning

confidence: 99%

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Effects of oral calcium on reproduction and postpartum health in cattle: a meta-analysis and quality assessment

Ma,

Zhao

et al. 2024

Front. Vet. Sci.

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Postpartum blood calcium (Ca) concentration is related to the reproduction and health of cattle. Oral calcium supplements were given to dairy cows after calving to increase blood Ca concentration and reduce the risk of hypocalcemia. However, studies have shown that oral Ca has different effects in preventing disease. The purposes of this study were (i) to conduct a meta-analysis to evaluate the expected effect of oral Ca on incidence of calving-related diseases, pregnancy risk and milk yield in dairy cows, and (ii) to make a quality assessment of these related studies. In total, 22 eligible studies were included in this review. Meta-analysis showed that oral Ca could significantly reduce the incidence of hypocalcemia (clinical hypocalcemia: relative risk (RR) = 0.67, 95% confidence interval (CI) = [0.52, 0.87]; subclinical hypocalcemia: RR = 0.81, CI = [0.72, 0.91]), and incidence of retained placenta (RR = 0.77, CI = [0.62, 0.95]), improved blood Ca concentrations: mean difference (MD) = 0.08; 95% CI = [0.04, 0.11]. For other results, the meta-analysis revealed a lack of evidence of the correlation between oral Ca and serum magnesium (Mg) / phosphorus (P) concentration (Mg: MD = −0.04; 95% CI = [−0.10, 0.02]; P: MD = 0.05; 95% CI = [−0.10, 0.21]) or incidence of other calving-related disorders (metritis: RR = 1.06, CI = [0.94, 1.19]; ketosis: RR = 1.04, CI = [0.91, 1.18]; mastitis: RR = 1.02, CI = [0.86, 1.21]; displacement of the abomasum: RR = 0.81, CI = [0.57, 1.16]) or pregnancy risk (pregnancy risk at first service: RR = 0.99, CI = [0.94, 1.05]; overall pregnancy rate: RR = 1.03, CI = [0.98, 1.08]) or milk yield (MD = 0.44; 95% CI = [−0.24, 1.13]). The distribution of the funnel plot formed by the included studies was symmetrical, and the Egger’s test had a p > 0.05, indicating that there was no significant publication bias. Sensitivity analyses results suggested that the results of meta-analysis are robust. Quality assessment of the included studies revealed that the risk of bias was focused on selection bias, performance bias, detection bias and other sources of bias, and the future research should focus on these aspects.

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