Effect of animal contact and microbial exposures on the prevalence of atopy and asthma in urban vs rural children in India

Vedanthan, P.K.; Mahesh, P A; Vedanthan, Rajesh; Holla, Amrutha D.; Liu, Andrew H.

doi:10.1016/s1081-1206(10)63552-1

Cited by 43 publications

(27 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is possible that early pet exposure in rural areas may prevent the development of atopic sensitisation (32,40,41); high-dose exposure to cat dander has been associated with clinical tolerance with a modified Th-2 immune response leading to the production of G4 instead of E antibodies (42,43). However, these observations differ from those in Kuwait showing that pet ownership increased the risk of sensitization to pets and those in Cyprus where there was lack of association between pet sensitization and pet ownership in an urban setting (44,45).…”

Section: Allergen Exposurementioning

confidence: 99%

See 1 more Smart Citation

Asthma Symptoms and Airway Narrowing in Children Growing up in an Urban versus Rural Environment

2009

View full text Add to dashboard Cite

The development of asthma and allergy appears to be the result of gene-environment interaction. Potential environmental risk factors such as outdoor and indoor air pollution, infections, allergen exposure, diet, and lifestyle patterns may trigger respiratory symptoms and compromise lung function in children. Specific features of urban and rural lifestyle may constitute distinct risk factors but may also coexist within certain socioeconomic levels. Children of rural environments are at lower risk for asthma and aeroallergen sensitization. The protective effect has been associated with close contact with large animals, but the genetic factor also plays a contributory role. Children with prolonged exposure to urban environment are at increased risk of reduced lung function and those that reside in polluted areas exhibit slower lung growth. It is possible that polluted urban environment per se facilitates subclinical small airway disease. Evidence to date supports a strong relation between residential area as a potential risk factor for childhood asthma symptoms and airway obstruction and a western type of socioeconomic development.

show abstract

Section: Allergen Exposurementioning

confidence: 99%

“…Children living in rural environment seem to be at lower risk of asthma than their urban counterparts (6); moreover, children living in a farming environment are at decreased risk of developing asthma (6)(7)(8). In addition, children exposed to outdoor or indoor air pollutants experience aggravation of their symptoms (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Asthma Symptoms and Airway Narrowing in Children Growing up in an Urban versus Rural Environment

2009

View full text Add to dashboard Cite

show abstract

“…Numerous studies have also associated early-life animal exposure-especially to dogs, cows, and pigs, and animal farming or rural living lifestyles-with less atopic dermatitis, allergic sensitization, and/or asthma; some of these studies are also of a longitudinal, prospective study design, stronger for inferences of causation. [130][131][132][133][134][135] These animals/ lifestyles have been associated with higher levels of endotoxin in house dust and ambient air samples. 129,[136][137][138][139] Other microbial PAMP exposures may also protect against the development of allergy and/or asthma.…”

Section: Tlr Stimulation and Allergy/asthma Prevention In Mouse To Manmentioning

confidence: 99%

Innate microbial sensors and their relevance to allergy

Liu

2008

Journal of Allergy and Clinical Immunology

Self Cite

View full text Add to dashboard Cite

“…De entre as inúmeras referências a estudos epidemiológicos, avultam as que concluem que crianças, nascendo e crescendo em quintas, em contacto com currais e feno acumulado em palheiros, vêm a revelar menos asma e atopia do que populações vizinhas com estilo de vida mais próximo do urbano, efeito tanto mais nítido quanto mais precoce a exposição 85 . Algumas especificidades são as de certos estilos de vida, como acontece em algumas comunidades da península hindustânica, onde é íntimo o contacto doméstico com animais, de grande porte ou gatos durante a noite, que levariam a que as crianças desen-or cats during the night, leading the children to develop less asthma, rhinitis and allergy 87,88 . The same is seen for the habitual consumption of non-pasteurised milk 85 .…”

Section: Os Produtos Bacterianosunclassified

“…Repeated exposure to endotoxins and other bacterial products leads to a refractory situation in response to re-exposure. Romagnani 92 argues for an effect of Infecção na modulaçâo da asma J Pinto Mendes volvessem menos asma, rinite e atopia 87,88 . O mesmo para o consumo habitual de leite não pasteurizado 85 .…”

Section: Os Produtos Bacterianosmentioning

confidence: 99%

Infecção na modulaçâo da asma11Trabalho apresentado no XXIII Congresso de Pneumologia da SPP – Guarda, Novembro 2007 / Paper presented at the XXIII Congresso de Pneumologia da SPP / PSP Pulmonology Congress, Guarda, November 2007

Mendes¹

2008

Revista Portuguesa de Pneumologia

View full text Add to dashboard Cite

publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. R e v i s t a P o r t u g u e s a d e P n e u m o l o g i a 647 Vol XIV N.º 5 Setembro/Outubro 2008 Artigo de Revisão Review ArticleResumo Faz -se uma revisão da influência das infecções no aparecimento e na clínica da asma brônquica. Dá -se o relevo que merece à intervenção virusal, sobretudo ao rinovírus, pela sua influência nas exacerbações, e ao vírus sincicial respiratório, sobre o qual recai a suspeita de poder ser causa determinante no aparecimento da síndroma asmática. Tentam -se esclarecer os mecanismos da resposta imune à agressão virusal em função das debilidades da resposta do asmático e do atópico, sobretudo no período perinatal, salientando -se, ainda, um efeito de potenciação da agressão virusal sobre a resposta atópica. Aborda -se a hipótese higiénica e a sua falta de consistência científica, pelo menos no papel que pretende atribuir a um não demonstrado antagonismo das respostas linfocitárias Th 1 e Th 2, apontando -se a importância actual da investigação, não das bactérias mas dos produtos bacterianos, como as endotoxinas, na modulação da asma e da AbstractThis paper reviews the impact of infections on the onset and clinical course of bronchial asthma. A just emphasis is given to the role viral infections, particularly rhinovirus infections, play in exacerbations, and that played by respiratory syncytial virus, suspected of triggering the asthmatic syndrome. The mechanisms of the immune response to virus attacks are explained, highlighting the asthmatic and allergic patient's weakened response, particularly in the perinatal period. Further stressed is a potentiating effect of viral aggression on the allergic response. The hygiene hypothesis and its lack of scientific consistency is detailed, at least as far as the role it seeks to confer on an unproven antagonism of the Th 1 and Th 2 lymphocyte responses. The current importance of research not into bacteria, but into bacterial products, including endotoxins, on the modulation of asthma and allergy is noted. Studies which, along these lines, show an Infecção na modulaçâo da asma 1 The role of infection in asthma 1 Recebido para publicação/R e v i s t a P o r t u g u e s a d e P n e u m o l o g i a 648 Vol XIV N.º 5 Setembro/Outubro 2008atopia, dando -se relevo aos estudos que, a partir deste modelo, demonstram uma influência do ambiente na secreção génica e, consequentemente, no fenótipo. Invocam -se, nas entrelinhas, vários mecanismos que podem explicar a asma neutrofílica que, para muitos, é um paradoxo perante o consagrado domínio do eosinófilo na inflamação asmática. Rev Port Pneumol 2008; XIV (5): 647-675Palavras-chave: Asma e infecção, asma e vírus, endotoxinas.environmental impact on genetic secretion in the phenotype are underlined. Also dis...

show abstract

Effect of animal contact and microbial exposures on the prevalence of atopy and asthma in urban vs rural children in India

Cited by 43 publications

References 36 publications

Asthma Symptoms and Airway Narrowing in Children Growing up in an Urban versus Rural Environment

Asthma Symptoms and Airway Narrowing in Children Growing up in an Urban versus Rural Environment

Innate microbial sensors and their relevance to allergy

Infecção na modulaçâo da asma11Trabalho apresentado no XXIII Congresso de Pneumologia da SPP – Guarda, Novembro 2007 / Paper presented at the XXIII Congresso de Pneumologia da SPP / PSP Pulmonology Congress, Guarda, November 2007

Contact Info

Product

Resources

About