Effect of angiotensinogen gene T235 variant on the development of diabetic complications in type II diabetes mellitus

McLaughlin, Kevin; Jagger, Carol; Small, M.; Jardine, AG

doi:10.1016/s0140-6736(95)91831-0

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Similarly, for stroke and various other atherosclerotic manifestations, such as restenosis after angio-Ž plasty or the presence of atherosclerotic lesions Kamitani . et al, 1995;McLaughlin et al, 1995 , there was no excess risk in TT homozygotes compared with MM homozygotes.…”

Section: Atheroslerotic Complicationsmentioning

confidence: 91%

Genetic polymorphisms in the renin–angiotensin system: relevance for susceptibility to cardiovascular disease

Wang

Staessen

2000

European Journal of Pharmacology

151

109

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Section: Atheroslerotic Complicationsmentioning

confidence: 91%

Genetic polymorphisms in the renin–angiotensin system: relevance for susceptibility to cardiovascular disease

Wang

Staessen

2000

European Journal of Pharmacology

151

109

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“…Thus, while several studies have reported an association between the ACE-D allele and diabetic nephropathy both in patients with IDDM [12] and NIDDM [14,17,18], other investigators have failed to confirm this relationship [13,16]. Although one preliminary report in a small group of patients with NIDDM (n = 76) failed to demonstrate a relationship between the AGT 235T-variant and diabetic nephropathy [15], the issue remains to be addressed in a larger population.…”

mentioning

confidence: 95%

“…Several recent studies have also examined the role of these genetic variants of the renin-angiotensin system on the development of diabetic nephropathy [12][13][14][15][16][17][18] and other renal diseases [19][20][21], but the results remain controversial. Thus, while several studies have reported an association between the ACE-D allele and diabetic nephropathy both in patients with IDDM [12] and NIDDM [14,17,18], other investigators have failed to confirm this relationship [13,16].…”

mentioning

confidence: 99%

Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension

et al. 1997

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Diabetic nephropathy, usually preceded by hypertension and persistent albuminuria, eventually develops in 30 to 50 % of patients with insulin-dependent (IDDM) or non-insulin-dependent (NIDDM) diabetes mellitus, and is one of the leading causes of end-stage renal failure in most industrialized countries. Based on the finding that both diabetic nephropathy [1] and hypertension [2] tend to cluster in families, it is anticipated that genetic markers can be identified which could allow the early detection of diabetic individuals prone to the development of this devastating complication.The renin-angiotensin system plays a central role in blood pressure regulation and renal function not only as a key regulator of sodium homeostasis, but also as a modulator of vascular tone and possibly vascular structure [3]. These effects are primarily mediated by angiotensin II which is liberated from angiotensinogen (AGT) by the sequential action of renin Diabetologia (1997) 40: 193-199 Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension Summary Recent studies have suggested an association between a deletion (D) variant of the angiotensin-converting-enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. The objective of our study was therefore to examine the relationship between these genetic variants of the renin-angiotensin system and diabetic nephropathy and hypertension, respectively, in a large (n = 661) group of Caucasian patients with insulin-dependent (n = 360) or non-insulin-dependent (n = 301) diabetes mellitus. The study had a power of 0.8 to detect a doubling of risk of nephropathy or hypertension in patients with the ACE-DD or AGT-235TT genotype, respectively. Allelic frequencies of the ACE-D and AGT-235T alleles were similar between patients with and without nephropathy in either type of diabetes, and accordingly, there was no significant association between diabetic nephropathy and the ACE or AGT genotype. Likewise, there was no significant association between the ACE or AGT genotype and hypertension. Thus, our data, in this large and ethnically homogeneous group of patients, do not support the hypothesis that these genetic variants of the renin-angiotensin system are strongly associated with either nephropathy or hypertension in patients with insulin-dependent or non-insulin-dependent diabetes mellitus. These genetic markers are therefore unlikely to serve as clinically useful predictors of either nephropathy or hypertension in Caucasian patients with diabetes. [Diabetologia (1997) 40: 193-199]

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“…The TT genotype is associated with higher plasma angiotensinogen levels (Fogarty et al, 1996). In contrast to Fogarty et al, most investigators could not observe a significant association of that AGI M235T gene polymorphism with diabetic nephropathy (Fogarty et al, 1996;McLaughlin et al, 1995;Ringel et al, 1997;. However, it should be noted that a significant interaction of the ACE insertion/deletion gene polymorphism and the angiotensinogen M2351 gene polymorphism has been recently described in patients with insulin-dependent diabetes mellitus showing proliferative retinopathy.…”

Section: A Variant Of the Angiotensinogen (Agt) Genementioning

confidence: 91%

Diabetic nephropathy and genetic alterations of the renin-angiotensin-system

Tepel¹,

Doberauer²,

Zidek³

2009

Exp Clin Endocrinol Diabetes

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Effect of angiotensinogen gene T235 variant on the development of diabetic complications in type II diabetes mellitus

Cited by 6 publications

References 2 publications

Genetic polymorphisms in the renin–angiotensin system: relevance for susceptibility to cardiovascular disease

Genetic polymorphisms in the renin–angiotensin system: relevance for susceptibility to cardiovascular disease

Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension

Diabetic nephropathy and genetic alterations of the renin-angiotensin-system

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