Effect of Angiogenesis in Bone Tissue Engineering

Huang, Jianhao; Han, Qixiu; Cai, Meiling; Zhu, Jing; Li, Lan; Yu, Lixin; Wang, Zhen; Fan, Gentao; Zhu, Yan; Lü, Jingwei; Zhou, Guangxin

doi:10.1007/s10439-022-02970-9

Cited by 30 publications

(16 citation statements)

References 130 publications

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“…In addition, we also observed differences in “angiogenesis” at the transcriptome level, suggesting that local oxygen release alleviated the severity of hypoxia within implants, tune hypoxia to a less serious level, which might be more favorable for vascularization. Previous studies emphasized the importance of oxygen supply in implants during the tight coupling of angiogenesis and tissue regeneration, such as bone and neural tissue [ [69] , [70] , [71] ]. In this study, the blood vessel formation in the PFTBA fiber group was significantly increased, compared to the Fiber group, which confirmed that the PFTBA fiber holds the potential of tuning the oxygen tension for the formation of blood vessels, paving a new avenue for achieving the long-term maintenance of nutrient supply at the defect site.…”

Section: Discussionmentioning

confidence: 99%

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Zheng

Xue

Wei

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Zheng

Xue

Wei

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

“…1) VEGF release promotes the mobilization and recruitment of endothelial (progenitor) cells, Frontiers in Bioengineering and Biotechnology frontiersin.org which helps to speed up the vascularization of bone tissue. (Huang et al, 2022). 2) In addition to sticking to VEGF, PDA coating can cling to bone progenitor cells, which promotes bone progenitor cell adhesion and reproduction (Wu et al, 2022;Zhang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Reconstruction failure in the allograft group was 55.3% ( Wisanuyotin et al, 2022 ). The success rate of bone reconstruction may be increased by accelerating the vascularization of the bone tissue scaffold ( Huang et al, 2022 ). Studies have shown that allogeneic bone combined with vascular growth factors promotes bone regeneration and increases osteoinduction ability ( Schmidmaier et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…VEGF was selected as a bioactive factor to promote angiogenesis and loaded on the surface of the allogeneic bone scaffold used in this study. Vascularized bone grafts accelerated bone remodeling and regeneration ( Huang et al, 2022 ). VEGF (especially VEGF-A) is a powerful angiogenic factor that attracts endothelial cells to bone tissue and controls the differentiation and functioning of osteoblasts and osteoclasts, as well as engaging in bone remodeling ( Zhang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Covalent immobilization of VEGF on allogeneic bone through polydopamine coating to improve bone regeneration

Huang

Lü

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Objective: Promoting bone regeneration and repairing in bone defects is of great significance in clinical work. Using a simple and effective surface treatment method to enhance the osteogenic ability of existing bone scaffold is a promising method. In this article, we study the application of catecholic amino acid 3,4-dihydroxyphenylalanine (DOPA) surface coating chelated with vascular endothelial growth factor (VEGF) on allogeneic bone.Method: Allogeneic bone is immersed in DOPA solution and DOPA form polydopamine (PDA) with good adhesion. Electron microscopy is used to characterize the surface characteristics of allogeneic bone. MC3T3-E1 cells were tested for biocompatibility and osteogenic signal expression. Finally, a 12-week rabbit bone defect model was established to evaluate bone regeneration capability.Results: We found that the surface microenvironment of DOPA bonded allogeneic bone was similar to the natural allogeneic bone. VEGF loaded allografts exhibited satisfying biocompatibility and promoted the expression of osteogenic related signals in vitro. The VEGF loaded allografts healed the bone defect after 12 weeks of implantation that continuous and intact bone cortex was observed.Conclusion: The PDA coating is a simple surface modification method and has mild properties and high adhesion. Meanwhile, the PDA coating can act on the surface modification of different materials. This study provides an efficient surface modification method for enhancing bone regeneration by PDA coating, which has a high potential for translational clinical applications.

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Dual Photo‐Enhanced Interpenetrating Network Hydrogel with Biophysical and Biochemical Signals for Infected Bone Defect Healing

Jian

Ying

et al. 2023

Adv Healthcare Materials

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The healing of infected bone defects (IBD) is a complex physiological process involving a series of spatially and temporally overlapping events, including pathogen clearance, immunological modulation, vascularization, and osteogenesis. Based on the theory that bone healing is regulated by both biochemical and biophysical signals, in this study, a copper doped bioglass (CuBGs)/methacryloyl‐modified gelatin nanoparticle (MA‐GNPs)/methacrylated silk fibroin (SilMA) hybrid hydrogel is developed to promote IBD healing. This hybrid hydrogel demonstrates a dual‐photocrosslinked interpenetrating network mechanism, wherein the photocrosslinked SilMA as the main network ensures structural integrity, and the photocrosslinked MA‐GNPs colloidal network increases strength and dissipates loading forces. In an IBD model, the hydrogel exhibits excellent biophysical characteristics, such as adhesion, adaptation to irregular defect shapes, and in situ physical reinforcement. At the same time, by sequentially releasing bioactive ions such as Cu2+, Ca2+, and Si2+ ions from CuBGs on demand, the hydrogel spatiotemporally coordinates antibacterial, immunomodulatory and bone remodeling events, efficiently removing infection and accelerating bone repair without the use of antibiotics or exogenous recombinant proteins. Therefore, the hybrid hydrogel can be used as a simple and effective method for the treatment of IBD.

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Effect of Angiogenesis in Bone Tissue Engineering

Cited by 30 publications

References 130 publications

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Covalent immobilization of VEGF on allogeneic bone through polydopamine coating to improve bone regeneration

Dual Photo‐Enhanced Interpenetrating Network Hydrogel with Biophysical and Biochemical Signals for Infected Bone Defect Healing

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