Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome

Welgan, Peter R.; Meshkinpour, Hooshang; Beeler, Michael

doi:10.1016/0016-5085(88)90006-6

Cited by 205 publications

(103 citation statements)

References 11 publications

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“…A further confounding factor may be the effect of exogenous stimuli such as stress. Many patients claim that stress exacerbates their symptoms, and it has been shown that stress increases colonic motility in patients with irritable bowel syndrome, 2,18,19 although in some studies this response has been shown to be no more exaggerated than in normal healthy volunteers. 4,20 Emotion, in the form of anger, has also been shown to enhance rectal visceral sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Houghton¹,

Rogers

Whorwell³

et al. 1997

Aliment Pharmacol Ther

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The pathophysiology of irritable bowel syndrome is poorly understood, but studies have suggested that disordered motility of both the small 1±3 and large bowel, 4±8 and abnormalities in gut visceral sensation, 9±15 may play important roles. The most consistent motor abnormality in the small bowel is a marked increase in`cluster activity' seen in the wakeful state but not during sleep, 1±3 whilst in the colon motility in many patients appears to be exaggerated, particularly after meals. 4±8 The main defect of visceral sensation appears to be hypersensitivity, and this has been demonstrated in the entire length of the gastrointestinal tract in patients with irritable bowel syndrome. 3, 9±15 Current therapy is far from satisfactory, ranging from modi®cations in diet to pharmacological intervention. SUMMARYBackground: Zamifenacin is a new potent gut M 3 selective muscarinic antagonist developed for possible use in irritable bowel syndrome. Methods: In this multicentre, double-blind, parallel group, placebo-controlled study, the effect of a single dose of zamifenacin 10 mg or 40 mg on both fasting (30 min) and fed (60 min) colonic motor activity was assessed in 36 patients with irritable bowel syndrome (aged 25±68 years; 19 male). Colonic motility was recorded using a ®ve-channel solid-state catheter introduced by colonoscopy to a depth of 35 cm in an unprepared colon. Results: Zamifenacin 40 mg profoundly reduced colonic motility, particularly after the meal (P < 0.05). This was re¯ected by a signi®cant reduction in the mean amplitude of contractions, number of contractions,

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Section: Discussionmentioning

confidence: 99%

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Houghton¹,

Rogers

Whorwell³

et al. 1997

Aliment Pharmacol Ther

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show abstract

“…Cold presser test stress, interviews and arithmetic calculations increased colonic motility as measured by both manometry and EGG (Chaudhary and Truelove, 1961;Nruducci et al, 1985;Rao et al, 1998;Welgan et al, 1985). Psychological stressors producing anger and anxiety also increased the colonic motility in normal healthy controls and irritable bowel syndrome patients (Welgan et al, 1985(Welgan et al, , 1988. MDT-related Table 2 (1).…”

Section: Colonic Activitymentioning

confidence: 99%

Local differences in electrogastrographic responses to the stress of the mirror drawing test (MDT) as determined by multichannel electrogastrography

Homma

2012

J. Smooth Muscle Res.

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Electrogastrograms (EGGs) were recorded in human subjects (n=58) at 16 locations on the thoraco-abdominal surface before (at rest) and during the stress of the mirror drawing test (MDT) and after having a test meal. The power amplitude ratios and power content ratios of MDT to rest (MDT/rest) and postprandial state to rest (PPR/rest) were compared between gastric channels 5 and 8, and the infraumbilical channels 12, 13, 14, 15, and 16. Generally, the ratio of the 3-cpm group in channels 5 and 8 was lower than that of the infraumbilical channels 12-16 during MDT. In contrast, the ratios were higher in the epigastric channels than in the infraumbilical channels after a test meal. Significant differences between the epigstric and infraumbilical channels were found in the comparisons of the power content ratios. The infraumbilical channels were facilitated and the epigastric channels inhibited during MDT. After eating a meal, in contrast, the postprandial epigastric 3-cpm EGGs were facilitated. The epigastric 3-cpm EGG activity reflects gastric myoelectric activity, while the infraumbilical 3-cpm activity reflects that of the colon. Therefore, it is suggested that the acute stress of the MDT generally inhibited the gastric EGG and facilitated the colonic EGG, indicating gastric inhibition and colonic facilitation. The topographic EGG maps of the power content ratios and the absolute power ratios visually confirmed these findings.

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“…33 CRF can induce an increase in colonic motility and in IBS this motility effect is markedly increased compared to normal individuals. 34 The exact neural and hormonal pathways that increased excess gut sensitivity and altered contractility during stress are not defined. Psychological stress can lead to permanent alterations in the HPA axis, the descending pain modulatory system, the immune system and the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Study evaluating chronic abdominal pain and functional abdominal pain syndrome

Gupta¹,

Gupta²,

Sharda³

et al. 2015

Int J Res Med Sci

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Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome

Cited by 205 publications

References 11 publications

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Local differences in electrogastrographic responses to the stress of the mirror drawing test (MDT) as determined by multichannel electrogastrography

Study evaluating chronic abdominal pain and functional abdominal pain syndrome

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Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome

Cited by 205 publications

References 11 publications

Zamifenacin (UK‐76, 654), a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Zamifenacin (UK‐76, 654), a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Local differences in electrogastrographic responses to the stress of the mirror drawing test (MDT) as determined by multichannel electrogastrography

Study evaluating chronic abdominal pain and functional abdominal pain syndrome

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Product

Resources

About

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome

Zamifenacin (UK‐76, 654), a potent gut M₃ selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome