Effect of Anemia in High-Risk Groups of Patients With Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention

Kurek, Tomasz; Lenarczyk, Radosław; Kowalczyk, Jacek; Świątkowski, Andrzej Marian; Kowalski, Oskar; Stabryła-Deska, Joanna; Honisz, Grzegorz; Lekston, Andrzej; Kalarus, Zbigniew; Kukulski, Tomasz

doi:10.1016/j.amjcard.2009.10.036

Cited by 45 publications

(46 citation statements)

References 24 publications

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“…However, the precise mechanisms by which the adverse effects of anemia on in-hospital outcomes are augmented, especially in AMI patients with a Killip 2-4 status remain uncertain. A recent report by Polish investigators demonstrated that, in AMI patients treated with PCI in the acute phase, the presence of anemia on admission is independently associated with higher short-and long-term mortality rates, particularly in subgroups with multivessel disease and incomplete revascularization (18). According to that report, among AMI patients with left ventricular dys-function (ejection fraction <40%), the presence of anemia on admission tends to be associated with long-term mortality (HR 1.61, 95% CI 1.36-1.86, p=0.0578) (18).…”

Section: Discussionmentioning

confidence: 99%

Predictors of In-hospital Outcomes after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with a High Killip Class

et al. 2014

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Objective The predictors of in-hospital outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated with heart failure or cardiogenic shock at presentation remain unclear. Methods Using the AMI-Kyoto Multi-Center Risk Study database, the clinical background characteristics, angiographic findings, primary PCI results, and in-hospital prognoses were retrospectively compared between primary PCI-treated AMI patients with a Killip class status of ! 2 (Killip 2-4 patients, n=390) and those with a Killip class 1 status (Killip 1 patients, n=1,057). Results The Killip 2-4 patients were more likely to have a higher age and proportion of women and exhibited a higher prevalence of previous myocardial infarction, diabetes mellitus and chronic kidney disease or anemia on admission, lower systolic blood pressure (SBP) values on admission, a higher rate of multivessels or left main trunk as the culprit artery, a larger number of diseased vessels, a lower Thrombolysis In Myocardial Infarction (TIMI) grade in the infarct-related artery (IRA) before/after primary PCI and a significantly higher in-hospital mortality rate than the Killip 1 patients. According to a multivariate analysis, age was found to be an independent positive predictor of in-hospital mortality, while admission SBP was an independent positive predictor of in-hospital survival in both groups. In contrast, anemia on admission was found to be an independent predictor of in-hospital death, while the TIMI 3 flow in the IRA after PCI was found to be an independent factor for survival in the Killip 2-4 patients, but not the Killip 1 patients. Conclusion Anemia on admission and the final TIMI 3 flow in the IRA are critical determinants of inhospital death in AMI patients with a Killip class status of ! 2 undergoing primary PCI.

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Section: Discussionmentioning

confidence: 99%

Predictors of In-hospital Outcomes after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with a High Killip Class

et al. 2014

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“…[5][6][7]9,[23][24][25][26] The multiple regression models showed that this relationship persisted even after adjustment with GRACE risk score. 18 Sabatine et al 3 did not find an increase in cardiovascular mortality, myocardial infarction, or recurrent ischemia in non-STEMI patients until hemoglobin values dropped below 10 g/dL.…”

Section: Mortalitymentioning

confidence: 99%

Impact of Anemia on In-Hospital, One-Month and One-Year Mortality in Patients with Acute Coronary Syndrome from the Middle East

Sulaiman¹,

Panduranga²,

Al‐Zakwani³

et al. 2012

Clinical Medicine & Research

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“…It is obvious that patients after AMI with anemia have greater cardiovascular risk [1][2][3][4][5][6], whereas in patients without anemia at admission the risk stratification remains equivocal. Easy and cheap parameters that would help in a better determination of prognosis are needed.…”

Section: Introductionmentioning

confidence: 99%

Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

et al. 2015

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Effect of Anemia in High-Risk Groups of Patients With Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention

Cited by 45 publications

References 24 publications

Predictors of In-hospital Outcomes after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with a High Killip Class

Predictors of In-hospital Outcomes after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Patients with a High Killip Class

Impact of Anemia on In-Hospital, One-Month and One-Year Mortality in Patients with Acute Coronary Syndrome from the Middle East

Could an analysis of mean corpuscular volume help to improve risk stratification in non-anemic patients with acute myocardial infarction?

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