Effect of androgen level on the abortion rate in chinese women after assisted reproduction technology

Abstract

OBJECTIVE: To determine the effect of androgen level on the abortion rate during in vitro fertilization embryo transfer (IVF-ET).DESIGN: A retrospective cohort study. MATERIALS AND METHODS: Total 7374 infertile women who received IVF-day 3 embryo transfer fresh cycles with autologous oocytes from January 2009 to December 2016 at the Center for Reproductive Medicine in Peking University Third Hospital were included. Only the first infertility treatment ended with early intrauterine pregnancies was eligible for the study. Patients were divided into two groups: hyperandrogenism (HA, n ¼ 1275) and normal androgen (non-HA, n ¼ 6099).RESULTS: a total of 6290 women resulted in live births and gave birth to 4471 live birth singletons and 1819 twins. 1070 women ended with abortion and 14 women ended with stillbirth. Live-birth rates in HA group was significantly lower than that in non-HA group. The abortion rate in HA group was significantly higher than that in non-HA group (17.18% vs. 13.95%, P¼0.003). The risk ratio suggested a 27.9% increase in abortion with HA women compared with non-HA group. The increased risk of abortion rate was largely driven by high risks associated with late abortion rate in HA group than that in non-HA group (36.53% vs. 27.03%, P¼0.006). There was no significant difference in the preterm rate, cesarean section (CS) rate, and live-birth sex ratio between groups stratified by androgen level.CONCLUSIONS: Androgen level was significantly influential factors on the abortion rate in Chinese women after assisted reproduction technology.