Effect of ancillary ligands on the topoisomerases II and transcription inhibition activity of polypyridyl ruthenium(II) complexes

The Anticancer Activities of Some Nitrogen Donor Ligands Containing bis-Pyrazole, Bipyridine, and Phenanthroline Moiety Using Docking Methods

“…The HOMO has the poorest correlation with the binding activities of the ligands which range from 0.00 to 0.18. The better correlation of the LUMO with the receptor interactions further supports the hypothesis that the lower the LUMO energy of inhibitors the easier the overlapping of it with the HOMO of the DNA [ 54 ]. However, other factors like the hydrophobicity and electronic effect of the ligands play significant roles in their inhibitory activities [ 54 ].…”

In vitro DNA and BSA-binding, cell imaging and anticancer activity against human carcinoma cell lines of mixed ligand copper(II) complexes

“…Investigation of new complexes by using various metals and ligands is necessary to understand role and importance of the effect factors on the medicinal properties. The effect of ancillary ligands on the biological and anticancer activity of polypyridyl complexes has also been examined [20,21]. It is found that ancillary ligands with the higher planarity and hydrophobicity are beneficial in biological and anticancer activity of their complexes.…”

Inhibition of in vitro transcription by 2-arylidene derivatives of thiazolo[3,2-α]benzimidazol-3(2H)-one

“…Moreover, the structure of its active site is similar to that of other viral, bacterial and eukaryotic polymerases [5,6]. T7 RNAP is thus a reliable in vitro model used for the studies of transcription [3][4][5][6] and mechanism of action of DNAbinding drugs [7][8][9][10]. This system was proposed in our previous papers for the screening of nucleic acids synthesis inhibitors [11][12][13].…”