Effect of anatomic injection site, age and smoking on the immune response to hepatitis B vaccination

Shaw, Frederic E.; Guess, Harry A.; Roets, J.M.; Mohr, F.E.; Coleman, Patrick J.; Mandel, Eric J.; Roehm, Robert R.; Talley, W.S.; Hadler, Stephen C.

doi:10.1016/0264-410x(89)90157-6

Cited by 239 publications

(143 citation statements)

References 21 publications

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“…In addition, high levels of alcohol consumption have been linked to reduced vaccine efficacy [61] and alcoholics have been shown to have poorer responses to some serotypes of the pneumococcal vaccine than non-alcoholic controls [62]. Similarly, cigarette smoking has been linked to reduced response to influenza [63,64], and hepatitis B vaccinations [65][66][67]. It has also been suggested that nutritional status may influence vaccine efficacy; supplementation with zinc, selenium [68], and vitamin E [69] improved the response to influenza vaccination in institutionalised elderly participants.…”

Section: Indirect Mechanismsmentioning

confidence: 99%

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymusdependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

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Section: Indirect Mechanismsmentioning

confidence: 99%

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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“…Therefore, we do not know whether these factors were evenly distributed within the 3 groups, and whether the negative results had any association with these factors. 34,35 Besides, the generalizability of these results is limited as a result of possible volunteer bias in this study.…”

Section: Discussionmentioning

confidence: 86%

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

Yao

Chen

et al. 2015

Human Vaccines & Immunotherapeutics

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y These authors equally contributed to this work. Keywords: Hepatitis B vaccine, immunization, adults, ChinaThe purpose of this study was to compare the response of hepatitis B vaccination with different vaccination schedules among seronegative adults, and to provide suitable vaccination schedules for floating and fixed population. The study included adults aged 20 to 39 y without prior history of vaccination with hepatitis B vaccine. The serum samples were collected and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels. Out of all, 686 adults who were negative for anti-HBs, anti-HBc and HBsAg were vaccinated with 10 ug hepatitis B vaccine at 0, 1 and 3, 6 or 12 month schedules, and their antibody titers were monitored. The rates of completion of the vaccination in floating and fixed population were 90.4% and 94.1% respectively (p D 0.061). The anti-HBs positive rates in adults vaccinated at 0, 1 and 3 ,6 or12 month were 83.9%, 88.2% and 94.2% respectively (P D 0.0003). The corresponding geometric mean titers (GMTs) were 61.19 (95%CI:47.10-81.23) mIU/mL, 214.04(95%CI:157.14-291.61) mIU/mL and 345.78(95%CI:251.25-475.77) mIU/mL, respectively ( P < 0.0001). Vaccination of hepatitis B with both 0-1-6 and 0-1-12 month schedules in adults result in better level of immune responses. Also, a longer vaccination schedule (0-1-12 month) may be more suitable for floating population and 0-1-6 month schedule is recommended for the fixed population.

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“…The well known historical factors include male sex, advanced age, smoking, obesity, alcohol intake, injection site and storage conditions, cirrhosis, immune suppression, diabetes mellitus, chronic renal failure and genetically determined resistance, [17][18][19][20][21][22][23] apart from the dosage and immunization schedules. In our investigation, the 1 month GMT was significantly higher in females than in males without significant difference of seroconversion, which was consistent with other research.…”

Section: Discussionmentioning

confidence: 99%

“…24 Furthermore, advanced age was the main demographic variable with a significant impact on the seroconversion rates and GMT, regardless of the dose and number of doses administered, which is in agreement with other trials. 17,19 Given that younger adults had good immunization, hepatitis B vaccine is recommended for younger individuals. In terms of the vaccination schedule, all 3 of the 3-dose schedules induced high seroconversion rates, while the 0-1-12 schedule was the first choice due to its higher sero-protective rate at 12 months and GMT at both time points.…”

Section: Discussionmentioning

confidence: 99%

Optimal vaccination program for healthy adults in China

Yao

Qiu

Chen

et al. 2015

Human Vaccines & Immunotherapeutics

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These authors equally contributed to this work. Keywords: adult vaccination, anti-HBs titers, hepatitis B vaccine, immunogenicityThere is still no suitable routine hepatitis B immunization strategy for adults in China. To establish an optimal vaccination schedule for healthy adults, we investigated various schedules in healthy adults. In this randomized 5143 healthy adults received 10 mg hepatitis B vaccine at 0, 1 and 3 months(group A), 0, 1 and 6 months(group B), or 0, 1 and 12 months(group C). Blood samples were collected after 1 month and 12 months after the third dose. The geometric mean titer (GMT), seroconversion rate (levels of anti-HBs 10 mIU/mL) and high response rate (levels of antiHBs 100 mIU/mL) were assayed. In our study, 2438 healthy adults finished the full vaccination program and follow-up. The seroconversion/sero-protective rate of groups A-C at one and 12 month after administration of the third vaccine dose was 100%, 99.9% and 97.9% verse 64.9%, 75.7% and 79.0%, respectively. GMT for anti-HBs tested in group A to C within 1 or 12 month after the third vaccination was 213.16, 432.58 and 451.47 mIU/ml verse 22.07, 46.70 and 56.18 mIU/ml, respectively. There were significant differences of seroconversion/sero-protective rate and GMT among the 3 groups (p < 0.01). Given the high anti-HBs seroconversion rate and GMT in all 3 groups, a flexible schedule for Hepatitis B vaccine should be recommended to adults, but 0-1-12 schedule is a better choice.

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Effect of anatomic injection site, age and smoking on the immune response to hepatitis B vaccination

Cited by 239 publications

References 21 publications

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

Optimal vaccination program for healthy adults in China

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