Effect of analogues of steroid and thyroxine hormones on wound healing in hamsters

Pirk, F; Elattar, T. M. A.; Roth, Genevieve D.

doi:10.1111/j.1600-0765.1974.tb00684.x

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…44 Although Pirk et al reported no change in wound healing with 1.3 μg/100 mg body weight intraperitoneal T 4 in hamsters, the investigators noted increased rate of fracture repair. 45 Ashton et al also reported increased fracture repair rate in mice given 20 μg/100 mg body weight subcutaneous T 4 . 46 There are also reports of hypothyroid patients who required thyroid hormone to achieve healing of radiation induced neck fistulae.…”

Section: Skin Manifestation Of Thyroid Hormone Action On Other Tissuesmentioning

confidence: 94%

Thyroid hormone action on skin

Safer

2011

Dermato-Endocrinology

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The skin characteristics associated with thyroid hormone are classic. The name "myxedema" refers to the associated skin condition caused by increased glycosaminoglycan deposition in the skin. Generalized myxedema is still the classic cutaneous sign of hypothyroidism. It is caused by deposition of dermal acid mucopolysaccharides, notably hyaluronic acid. Despite its appearance, the skin does not pit with pressure.

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Section: Skin Manifestation Of Thyroid Hormone Action On Other Tissuesmentioning

confidence: 94%

Thyroid hormone action on skin

Safer

2011

Dermato-Endocrinology

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“…Thyroid therapy has been applied for the treatment of hypothyroid patients undergoing radiation-induced neck fistulae in several studies [13]. Although thyroid hormone enhances local response to growth factors and gene expression of keratins 6, 16, and 17 [14], certain studies do not support the therapeutic effects of thyroid hormone on skin wounds [15, 16]. …”

Section: Introductionmentioning

confidence: 99%

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

et al. 2012

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Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

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“…Thyroid hormone is also a collagen stimulator that leads to skin thickening [21,22]. However, the effects of thyroid hormone on wound healing are not well understood or supported [23,24]. …”

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confidence: 99%

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

et al. 2012

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Many research studies report the healing effects of Aloe Vera, thyroid hormone cream and silver sulfadiazine. However, the effects of these therapeutic agents are not well understood and have not been compared in one study. This study aimed at investigating the effects of topical application of an Aloe vera gel, a thyroid hormone cream and a silver sulfadiazine cream on the healing of skin wounds surgically induced in Wistar rats for determining the treatment of choice. In a randomized controlled trial, twelve male rats, aged 120 days and with a mean weight of 250 to 300 g, were divided randomly into 5 groups based on drug treatments: Aloe vera gel (AV), thyroid hormone cream (TC), silver sulfadiazine 1% (S), vehicle (V) and control. To evaluate the efficacy of each treatment technique, a biomechanical approach was used to assess tensile stress after 14 days of treatment. Tensile stress was significantly improved in the Aloe vera gel group as compared with the other four groups (P≤0.05). While the other treatment options resulted in better healing than the control group, this difference was not significant. We conclude that Aloe vera topical application accelerated the healing process more than thyroid hormone, silver sulfadiazine and vehicle in surgically induced incisions in rats.

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Effect of analogues of steroid and thyroxine hormones on wound healing in hamsters

Cited by 15 publications

References 5 publications

Thyroid hormone action on skin

Thyroid hormone action on skin

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

A comparative study of the effects of topical application ofAloe vera,thyroid hormoneandsilver sulfadiazineon skin wounds inWistarrats

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