Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents

Abstract

3-Butyl-1-methyl-1H-imidazol-3-iumbis((trifluoromethyl)sulfonyl)amide [Bmim][Tf 2 N] as an environmentalfriendly solvent was added to the reaction media for synthesis of some new azole compounds as antifungal agents. The effect of [Bmim][Tf 2 N] on the rate of reactions was studied using NMR analysis. The results show remarkable increasing in the progress of the reactions. As in recent years the developments of resistance to currently available antifungal azoles in Candida spp., as well as clinical failures in the treatment of fungal infections have been reported therefore intense efforts in antifungal drug discovery are still needed to develop more promising and effective antifungal agents for use in the clinical arena. We present a synthetic route for producing antifungal that is improved by using an ionic liquid.