Effect of an Intra-Uterine Plastic Coil on the Oestrous Cycle of the Heifer

Ginther, O.J.; Woody, C. O.; Janakiraman, K; Casida, L. E.

doi:10.1530/jrf.0.0120193

Cited by 45 publications

(23 citation statements)

References 3 publications

(3 reference statements)

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“…The findings are consistent with those demonstrated in the ewe by injecting a suspension of E. coli (Brins¬ field & Hawk, 1968) or benzyl alcohol (Woody, Ginther & Pope, 1969) into the uterus, and are also essentially in agreement with those reported by Ginther et al (1966), who inserted a polyethylene plastic coil into the uterus of the cow. …”

supporting

confidence: 90%

Local Effect of Intrauterine Injection of Iodine Solution on the Life-Span of the Corpus Luteum of the Cow

Nakahara¹,

Domeki²,

Yamauchi³

1971

Reproduction

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supporting

confidence: 90%

Local Effect of Intrauterine Injection of Iodine Solution on the Life-Span of the Corpus Luteum of the Cow

Nakahara¹,

Domeki²,

Yamauchi³

1971

Reproduction

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“…The minimal effective intrauterine (IU) dose of PGF (1-2 mg [6]) when given into the uterine horn ipsilateral to the corpus luteum (CL) in cattle is about one tenth of the minimal systemic dose (15 mg [7]). The IU effectiveness in cattle results from a unilateral utero-ovarian pathway [8,9]. Surgical anastomoses of the uterine vein or the ovarian artery ipsilateral of an intact uterine horn to the corresponding vessel on the unilaterally hysterectomized side have demonstrated that a venoarterial unilateral pathway adequately accounts for the local luteolytic effect of a uterine horn on the CL in the adjacent ovary [10].…”

Section: Introductionmentioning

confidence: 99%

Necessity of Sequential Pulses of Prostaglandin F2alpha for Complete Physiologic Luteolysis in Cattle1

Ginther

Araújo

Palhão

et al. 2009

Biology of Reproduction

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The luteolytic effects of exogenous prostaglandin F2alpha (PGF) that did and did not simulate natural 13,14-dihydro-15-keto-PGF (PGFM) pulses were studied during mid-diestrus in 42 Holstein heifers. Plasma concentrations of PGF were assessed by assay of PGFM. In experiment 1, a single intrauterine injection of 4.0 mg of PGF into the uterine horn ipsilateral to the corpus luteum resulted in a precipitous progesterone decline, whereas sequential injections of 0.25 or 1.0 mg every 12 h resulted in a stepwise decrease (P < 0.05) following each injection. A progesterone increase occurred during the first 5 min before the luteolytic decrease but only for the 4.0-mg dose. From the results of experiment 2, a 2-h intrauterine infusion of a total of 0.5 mg of PGF was judged to best simulate a natural PGFM pulse. In experiment 3, simulation of sequential pulses at 12-h intervals resulted in a continuous precipitous decrease in progesterone to <1 ng/ml by the beginning of the fourth simulated pulse. In contrast, a single simulated pulse resulted in a 6-h progesterone decrease to a constant concentration for 3 days after treatment, followed by a return to control concentrations. The mean +/- SEM interval between the pretreatment and posttreatment ovulations was shorter (P < 0.05) in the group with sequential simulated pulses (14 +/- 1 day) than in the group with a single pulse (21 +/- 1 day). Results indicated that excessive PGF doses may stimulate nonphysiologic progesterone responses and supported the hypothesis that sequential PGF pulses are required to stimulate natural luteolysis in cattle.

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“…The intrauterine effectiveness results from a unilateral utero-ovarian luteolytic pathway in cattle [12,13]; the PGF is transferred into the ovarian artery after intrauterine administration [14] through a local venoarterial pathway between the utero-ovarian vein and the ovarian artery [15].…”

Section: Introductionmentioning

confidence: 99%

Temporal Associations among Pulses of 13,14-Dihydro-15-keto-PGF2alpha, Luteal Blood Flow, and Luteolysis in Cattle1

Ginther

Silva²,

Araújo³

et al. 2007

Biology of Reproduction

140

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Luteal blood flow was studied in heifers by transrectal color-Doppler ultrasound. Data were normalized to the decrease in plasma progesterone to <1 ng/ml (Day 0 or Hour 0). Blood flow in the corpus luteum (CL) was estimated by the percentage of CL area with color flow signals. Systemic prostaglandin F2alpha (PGF) treatment (25 mg; n=4) resulted in a transient increase in CL blood flow during the initial portion of the induced decrease in progesterone. Intrauterine treatment (1 or 2 mg) was done to preclude hypothetical secondary effects of systemic treatment. Heifers were grouped into responders (luteolysis; n=3) and nonresponders (n=5). Blood flow increased transiently in both groups; induction of increased blood flow did not assure the occurrence of luteolysis. A transient increase in CL blood flow was not detected in association with spontaneous luteolysis when examinations were done every 12 h (n=6) or 24 h (n=10). The role of PGF pulses was studied by examinations every hour during a 12-h window each day during expected spontaneous luteolysis. At least one pulse of 13,14-dihydro-15-keto-PGF2alpha (PGFM) was identified in each of six heifers during the luteolytic period (Hours -48 to -1). Blood flow increased (P<0.02) during the 3-h ascending portion of the PGFM pulse, remained elevated for 2 h after the PGFM peak, and then decreased (P<0.03) to baseline. Results supported the hypothesis that CL blood flow increased and decreased with individual PGFM pulses during spontaneous luteolysis.

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Effect of an Intra-Uterine Plastic Coil on the Oestrous Cycle of the Heifer

Cited by 45 publications

References 3 publications

Local Effect of Intrauterine Injection of Iodine Solution on the Life-Span of the Corpus Luteum of the Cow

Local Effect of Intrauterine Injection of Iodine Solution on the Life-Span of the Corpus Luteum of the Cow

Necessity of Sequential Pulses of Prostaglandin F2alpha for Complete Physiologic Luteolysis in Cattle1

Temporal Associations among Pulses of 13,14-Dihydro-15-keto-PGF2alpha, Luteal Blood Flow, and Luteolysis in Cattle1

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