Effect of an Implantable Gentamicin-Collagen Sponge on Sternal Wound Infections Following Cardiac Surgery&lt;subtitle&gt;A Randomized Trial&lt;/subtitle&gt;

Bennett‐Guerrero, Elliott; Ferguson, T. Bruce; Lin, Min; Garg, Jyotsna; Mark, Daniel B.; Scavo, Vincent A.; Kouchoukos, Nicholas T.; Richardson, John B.; Pridgen, Renee L.; Corey, G. Ralph

doi:10.1001/jama.2010.1152

Cited by 130 publications

(130 citation statements)

References 25 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…Some studies have reported that an antibiotic-collagen sponge was effective for the prevention of DSWI. However, the results from different studies have been controversial (12,13,28,29). In this study, we showed that the group treated with intravenous antibiotic, sternal debridement and flap reconstruction had a better prognosis than the group treated with intravenous antibiotic and sternal debridement (30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 78%

Deep sternal wound infection after cardiac surgery in the Chinese population: a single-centre 15-year retrospective study

Pan¹,

Mo²,

Zhou³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Deep sternal wound infection (DSWI) is a severe complication following cardiac surgery. A retrospective study was implemented to determine the risks and clinical characteristics of DSWI after cardiac operation in the Chinese population.Methods: We analysed 7,944 consecutive patients who underwent cardiac surgery via median sternotomy from January 2002 to December 2016 at our institution. Multiple logistic regression analysis was used to identify risk factors for DSWI.Results: A total of 106 patients (1.33%) suffered from DSWI; significant risk factors included body mass index (BMI) (P=0.02; OR=1.08; 95% CI: 1.01-1.16) and reoperation (P<0.01; OR=5.93; 95% CI: 2.88-12.25).The most common bacterium involved in DSWI was staphylococcus aureus (23%). Among all DSWI patients, the overall survival rate of the group treated with flap reconstruction was significantly higher than that in the group treated with intravenous antibiotics and sternal debridement (87% vs. 59%, P=0.01).Conclusions: DSWI was associated with several risk factors. Effective intervention strategies could improve the outcome of patients undergoing cardiac surgery.

show abstract

Section: Discussionmentioning

confidence: 78%

Deep sternal wound infection after cardiac surgery in the Chinese population: a single-centre 15-year retrospective study

Pan¹,

Mo²,

Zhou³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…Sternal stabilization using rigid plates was compared to that using wire sternal closure and statistically significantly less common mediastinal infections were found in the group managed with plates (3). Furthermore, use of antibiotic soaked sponge inserted between sternal fragments was evaluated, but no difference was found as compared to the control group with regard to incidence of superficial or deep infections (4). Autologous platelet gel rich in growth factors applied topically on the sternum and in the subcutaneous tissue was analyzed and no difference was found with regard to incidence of infections between the study and control groups (5).…”

mentioning

confidence: 99%

Preliminary Outcome of Treatment of Postoperative Primarily Closed Sternotomy Wounds Treated Using Negative Pressure Wound Therapy

Witt-Majchrzak¹,

Żelazny²,

Snarska³

2015

Polish Journal of Surgery

View full text Add to dashboard Cite

Hospital infections, and in particular infections of the surgical site are a common problem of the procedural departments. Due to continuous progress of surgical techniques and patient population getting older with multiple co-morbidities, multidirectional actions need to be taken to avoid these infections or, if they do occur, achieve optimal treatment outcomes. Vacuum wound therapy is one of the directions that has been developed over the recent years.evaluate wound healing in patients after an off-pump coronary artery bypass grafting procedure, using the internal mammary artery, treated with negative pressure wound therapy system.This prospective, open label study evaluated healing of postoperative sternotomy wounds after their primary closure with negative pressure wound therapy, using continuous negative pressure of -80 mmHg in 40 patients and 40 patients in a control group in whom conventional dressings were applied in the postoperative period.The number of patients in whom primary wound healing occurred without complications was significantly higher in the negative pressure wound therapy group versus the control group (xNegative pressure wound therapy after primary wound closure reduces the risk of superficial infections in the population with multiple risk factors of complications in the sternotomy wound healing.

show abstract

“…In this context, new strategies have been developed to try to lower the SSI rate: preoperative mupirocin, collagen-gentamicin implants and triclosan-coated sutures. Hopes raised by these approaches have not yet been fulfilled [10][11][12]. It seems that the research concerning antibiotic prophylaxis has been left by the wayside, despite the numerous unanswered questions.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative vs 24-Hour Administration of Cefamandole to Prevent Deep Sternal Wound Infection and Endocarditis after Adult Cardiac Surgery

Maillet¹,

Thierry²,

Oghina³

et al. 2013

OJAnes

View full text Add to dashboard Cite

Background and Objectives: Duration of antibiotic prophylaxis for cardiac surgery is still debated and controversial. International guidelines are vague: French guidelines recommend an intraoperative administration, while the Society of Thoracic Surgeons' guidelines suggest that optimal postoperative prophylactic antibiotics be given for 48 hours or less. Very few studies have compared the same antibiotic with 2 different administration durations. The study was designed to compare the efficacy of 24-hour administration of cefamandole vs intraoperative cefamandole to prevent deep sternal wound infection and endocarditis after cardiac surgery. Methods: This retrospective and observational study compared the rates of severe surgical site infections (deep sternal wound infection, endocarditis) after cardiac surgery between period 1, 01/01/2008-31/08/2008, with 24-hour administration of cefamandole, and period 2, 01/09/2008-30/04/2009 with intraoperative cefamandole. Results: Among 933 patients, 14 patients (1.5%) developed surgical site infection during the 16-month study: 1.3% during the first period and 1.7% during the second (ns). The populations (470 patients in period 1 and 463 in period 2) were homogeneous and comparable for pre-, intra-and postoperative characteristics. Surgical site infection characteristics (pathogens involved, time to diagnosis) and consequences (longer hospital stay, outcomes) were comparable in the 2 groups. Conclusions: Intraoperative cefamandole was as safe as its 24-hour administration to prevent deep sternal wound infection and endocarditis after adult cardiac surgery.

show abstract

Effect of an Implantable Gentamicin-Collagen Sponge on Sternal Wound Infections Following Cardiac Surgery<subtitle>A Randomized Trial</subtitle>

Cited by 130 publications

References 25 publications

Deep sternal wound infection after cardiac surgery in the Chinese population: a single-centre 15-year retrospective study

Deep sternal wound infection after cardiac surgery in the Chinese population: a single-centre 15-year retrospective study

Preliminary Outcome of Treatment of Postoperative Primarily Closed Sternotomy Wounds Treated Using Negative Pressure Wound Therapy

Intraoperative vs 24-Hour Administration of Cefamandole to Prevent Deep Sternal Wound Infection and Endocarditis after Adult Cardiac Surgery

Contact Info

Product

Resources

About