Effect of an extension tube on the bronchodilator efficacy of terbutaline delivered from a metered dose inhaler.

Gomm, S A; Keaney, N. P.; Winsey, N J; Stretton, T. B.

doi:10.1136/thx.35.7.552

Cited by 36 publications

(9 citation statements)

References 16 publications

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“…The use of a spacer between the inhaler and the patient's mouth can potentially reduce the deposition of the drug on the oropharynx and may be preferred for patients who have difficulty using the inhaler correctly by the conventional method. [18][19][20] Another alternative is the "open mouth" method of administering inhaler medications, although evaluation of the efficiency of this method in drug delivery is still lacking. 21…”

Section: Discussionmentioning

confidence: 99%

An Education Program That Improves the Psychomotor Skills Needed for Metaproterenol Inhaler Use

O'Bey¹,

Jim²,

Gee³

et al. 1982

Drug Intelligence & Clinical Pharmacy

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This is the first report assessing an education program's impact on teaching patients the psychomotor skills needed for proper use of the metaproterenol inhaler. Most patients do not use pressurized inhalers correctly. This inability could lead to suboptimal or ineffective therapy. Pharmacists provided a standardized education program to asthma patients and to those with chronic obstructive pulmonary disease for three clinic visits. Proper use of the inhaler was assessed by evaluating the patient's psychomotor performance for each visit before and after instruction. Of 19 patients, 18 demonstrated a mean improvement of 33.5 percent from preinstruction to postinstruction evaluation at the first visit (Student's t-test, p less than 0.0005). Both preinstruction and postinstruction scores demonstrated an upward trend for all three visits, the postinstruction scores always being higher than the preinstruction scores. These results indicate that our standardized education program helped improve psychomotor performance. Certain instructional aspects that need emphasis in future education programs have been identified.

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Section: Discussionmentioning

confidence: 99%

An Education Program That Improves the Psychomotor Skills Needed for Metaproterenol Inhaler Use

O'Bey¹,

Jim²,

Gee³

et al. 1982

Drug Intelligence & Clinical Pharmacy

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“…Respiratory function parame ters selectively reflecting small airway di ameters were not included in their study. Both Gotnm et al [17] and Poppius [18] failed to find a significant effect of the ex tended mouthpiece. Gomtn et al [17] sug gest that patient selection may be a critical point.…”

Section: Discussionmentioning

confidence: 93%

“…Both Gotnm et al [17] and Poppius [18] failed to find a significant effect of the ex tended mouthpiece. Gomtn et al [17] sug gest that patient selection may be a critical point. As seen in our results, the choice of the respiratory function parameters may also be important.…”

Section: Discussionmentioning

confidence: 93%

Influence of an Extension Tube on the Bronchodilator Efficacy of Terbutaline Delivered from a Metered Dose Inhaler

Pauwels¹,

Lamont²,

Hidinger³

et al. 1984

Respiration

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Pressurized aerosols of sympathomimetic drugs are widely used in the treatment of bronchial asthma. The efficacy of this form of treatment is diminished in a number of patients by difficulties in coordination between the aerosol actuation and the inhalation. In order to improve the intrapulmonary deposition of terbutaline, an extension tube has been adapted to the regular pressurized aerosol device. In a cross-over randomized study we compared the bronchodilatory effect of increasing doses of terbutaline (250, 500 and 750 μg at 25-min intervals) either delivered by the regular pressurized aerosol device or by the device with the extension tube. The study was performed on 11 adult patients with reversible airways obstruction. Spirometry, body plethysmography and flow volume curves were performed. The onset of the bronchodilatory effect of a single dose of 250 μg terbutaline was more rapid after delivery via the extension tube. The addition of the extension tube caused a significantly higher bronchodilator efficacy of aerosolized terbutaline on the small airways. Our results show that the addition of an extension tube improves the bronchodilator efficacy of terbutaline delivered from a pressurized aerosol.

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“…2 This probably increases the potential for vasoactivity of the peripheral part of the vascular bed. 3 In infancy and childhood, abnormal vascular lung growth, associated with chronic hypoxia, was described. In victims of sudden infant death syndrome, increased muscularity of the pulmonary circulation was observed as evidenced by the extension of muscle into arteries not usually muscularized during the first year of life and by an increased thickness of the medial wall.…”

mentioning

confidence: 99%

Bronchodilator Drug Administration

Newhouse¹,

Dolovich²

1983

Am Rev Respir Dis

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Effect of an extension tube on the bronchodilator efficacy of terbutaline delivered from a metered dose inhaler.

Cited by 36 publications

References 16 publications

An Education Program That Improves the Psychomotor Skills Needed for Metaproterenol Inhaler Use

An Education Program That Improves the Psychomotor Skills Needed for Metaproterenol Inhaler Use

Influence of an Extension Tube on the Bronchodilator Efficacy of Terbutaline Delivered from a Metered Dose Inhaler

Bronchodilator Drug Administration

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