Effect of an experimental desensitizing agent on reduction of bleaching-induced tooth sensitivity

Parreiras, Sibelli Olivieri; Szesz, Anna Luiza; Coppla, Fabiana Madalozzo; Martini, Eveline Claudia; Farago, Paulo Vítor; Loguércio, Alessandro Dourado; Reis, Alessandra

doi:10.1016/j.adaj.2017.10.025

Cited by 27 publications

(37 citation statements)

References 41 publications

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“…observed in previous studies [19][20][21]30]. This marked sensitivity during bleaching treatments is directly related to the effect of H 2 O 2 particles on pulp cells, which leads to the release of inflammatory mediators [9,39,46]. These mediators are soluble and diffusible molecules that act locally in the inflammatory area, causing vasodilatation, increased vascular permeability, phagocytosis, apoptosis, and pain sensation [47,48].…”

Section: Plos Onementioning

confidence: 80%

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Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

et al. 2021

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Objective This split-mouth randomized controlled clinical trial assessed the effect of 10% strontium chloride in combination with photobiomodulation (PBM) for the control of tooth sensitivity (TS) post-bleaching. Methods The upper/lower, right and left quadrants of fifty volunteers were randomized and allocated to four groups (n = 25): PLACEBO—placebo gel + simulation of PBM; Placebo + PBM; STRONTIUM—10% strontium chloride + simulation of PBM; and PBM + STRONTIUM—10% strontium chloride + PBM. All groups received tooth bleaching treatment with 35% hydrogen peroxide. For the PBM treatment, the laser tip was positioned in the apical and cervical regions of the teeth bleached in the respective hemi-arch. The laser system was operated in continuous mode, using 1.7 J of energy. A dose of 60 J/cm2 was applied to each point for 16 seconds under 808 nm near-infrared light (100mW of power), with a point area of 0.028 cm2. TS was assessed during a 21-day follow-up, using the modified visual analogue scale. Results In the intragroup assessment, the Friedman test indicated that PBM + STRONTIUM promoted the greatest reduction in TS after the second week of treatment (p ≤ 0.05). The Wilcoxon-Mann-Whitney test indicated that the groups Placebo + PBM, STRONTIUM, and STRONTIUM + PBM did not differ statistically (p ≥ 0.05) in the first and third weeks of treatment The group PLACEBO exhibited the greatest TS in the first three days after each bleaching session. Conclusion The combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, the combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, it did not differ from the individual use of Placebo + PBM or STRONTIUM groups assessed after 21 days of follow-up.

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Section: Plos Onementioning

confidence: 80%

“…To that end, a split-mouth model was used. The experimental groups were randomly distributed on both sides of the dental arch [39]. This type of study does not consider inter-individual variability in estimates of treatment effect [40], also increasing its power without the need of large sample sizes [41].…”

Section: Plos Onementioning

confidence: 99%

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

et al. 2021

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“…Based on the positive results related to the topical application of desensitizers before or after in‐office bleaching, 15,20‐22 and in order to reduce the application time, desensitizers such as potassium nitrate and sodium fluoride have been incorporated into the bleaching agents 24,35,40 . The bleaching gel used in this study contains potassium nitrate in a concentration not reported by the manufacturer.…”

Section: Discussionmentioning

confidence: 99%

“…In an attempt to reduce the risk and intensity of TS, several therapies have been proposed, such as the application of desensitizing agents, 11,12,20‐22 administration of analgesic or anti‐inflammatory drugs, 23 incorporation of desensitizers into bleaching gel composition, 24 use of low‐concentrated agents 25 and decreasing of the contact time or in the number of bleaching gel applications 9,13,26 . Previous in vitro 16,18,19 or in animal 27 studies evaluated the toxicity or inflammatory responses of dental pulp after different in‐office bleaching protocols with HP gels.…”

Section: Introductionmentioning

confidence: 99%

Effects of a reduced in‐office bleaching protocol with 37.5% hydrogen peroxide on effectiveness and tooth sensitivity: A double‐blind randomized clinical trial

Meireles

Santos

Lustosa

et al. 2021

J Esthet Restor Dent

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Objective This randomized clinical trial evaluated the effectiveness and tooth sensitivity (TS) of 37.5% hydrogen peroxide (37.5HP) in‐office bleaching with reduced protocol. Materials and methods Forty participants with shade mean C2 or darker for the six maxillary anterior teeth were randomly allocated into two treatment groups (n = 20): two (37.5HP2) or three (37.5HP3) 8 min applications/clinical session. Three clinical sessions were performed with a 1 week interval. Color evaluations were done with a spectrophotometer at baseline and 1 week post‐bleaching. TS was measured during and up to 48 h after bleaching using a five‐point numeric rating scale. Color change was evaluated by Student's t‐test for independent samples. The absolute risk and intensity of TS were analyzed by Fisher's and Mann–Whitney/Friedman tests (p < 0.05). Result Both treatment groups resulted in a significant tooth whitening 1 week post‐bleaching (p < 0.001). There were no significant differences between 37.5HP2 and 37.5HP3 for ΔE*ab, ΔE00 and ∆WID. Also, there were not differences between groups regarding high absolute risk (p = 1.0) and low intensity of TS at all time assessments (p > 0.7). Conclusions The in‐office bleaching with two 37.5% HP applications produced the same whitening degree, risk and intensity of TS to that performed with three gel applications. Clinical significance Clinicians should opt to use a neutral 37.5% HP in‐office bleaching gel for two 8 min applications/clinical session because produces the same whitening effectiveness, risk and low intensity of TS as the protocol proposed by manufacturer (three 8 min applications).

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“…Then, we measured the distance in millimeters from the 0 end with the aid of a millimeter ruler. For each side of arch was measured pain by these scales and we emphasized to the participants that we were interested in differences between the right and left sides 9,11,38,39 …”

Section: Methodsmentioning

confidence: 99%

Assessment of the effect of experimental bleaching agent with nano‐bioactive material on postoperative sensitivity: A randomized, triple blind clinical trial

Burey

Sutil

Aldaz

et al. 2021

J Esthet Restor Dent

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Objectives This clinical study aimed to evaluate the effect of incorporating bioactive nanoparticles (n‐Bm) inside an in‐office bleaching gel on the risk and intensity of tooth sensitivity (TS) and on bleaching effectiveness. Materials and methods Sixty‐six participants were selected and randomly assigned into two groups: control–only in‐office gel and experimental‐in‐office gel with n‐Bm. Teeth were bleached in two sessions (3 × 15‐min). TS was recorded using a VAS and NRS. The color change was evaluated by subjective (VITA Classical and VITA Bleachedguide) and objective (Easyshade spectrophotometer) methods at baseline and 30 days after the end of treatment. The TS was evaluated by McNemar, Wilcoxon Signed Rank, and paired t test. The color changes between groups were compared using paired t test (α = 0.05). Results No significant differences between the groups were observed in the risk (control = 27% [95%IC 18–39]; experimental = 21% [95%IC 13–32]) and intensity of TS, as well as in the color change (p >0.05) for any color measurement. Conclusion The inclusion of n‐Bm into the bleaching agents did not affect the whitening effectiveness, as well as the risk and intensity of TS between groups. However, the results of the absolute risk of TS were low for both in‐office gels used. Clinical significance Despite no significant differences between groups, both experimental bleaching agents present suitable results with low values for TS.

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Effect of an experimental desensitizing agent on reduction of bleaching-induced tooth sensitivity

Cited by 27 publications

References 41 publications

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial

Effects of a reduced in‐office bleaching protocol with 37.5% hydrogen peroxide on effectiveness and tooth sensitivity: A double‐blind randomized clinical trial

Assessment of the effect of experimental bleaching agent with nano‐bioactive material on postoperative sensitivity: A randomized, triple blind clinical trial

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