Effect of an Excess Intake of Casein Hydrolysate Containing Val-Pro-Pro and Ile-Pro-Pro in Subjects with Normal Blood Pressure, High-Normal Blood Pressure, or Mild Hypertension

Effect of digestive enzymes on the bioactive properties of goat milk protein hydrolysates

“…This enzyme is a key component of the blood pressure regulation process (Johnston, 1992) and its inhibition helps control high blood pressure. Contrary to commercial ACE inhibitory drugs, food derived peptides have not shown any side effects, even at high doses (Ishida et al, 2011). The ACE inhibitory potential of goat milk protein hydrolysates has been reported in previous studies employing subtilisin or trypsin as enzymes Manso & L opez-Fandiño, 2003).…”

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

“…Peptides derived from natural food sources have attracted growing interest because of their potential health benefits associated with low molecular weight, high activity, easy absorption, and little or no negative side effects because of fast clearance from the blood . In fact, oral administration of 5-fold excess of casein protein-derived peptides to hypertensive and normotensive people over a 4-week period resulted in reduced blood pressure (BP) but without any adverse effect in all the groups (Ishida et al, 2011).…”

Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides

“…Therefore, research efforts in the past two decades have attempted to produce natural peptides as alternative inhibitory compounds to currently available ACE and renin inhibitory drugs. This is because, unlike synthetic compounds, antihypertensive natural peptides are likely to produce less severe negative side effects and there is reduced risk of overdose hazards as was shown for casein peptides (Ishida et al, 2011).…”