Effect of an Anticholinergic Agent on Riboflavin Absorption in Man

Levy, Gerhard; Gibaldi, Milo; Procknal, Josephine A.

doi:10.1002/jps.2600610529

Cited by 46 publications

(17 citation statements)

References 9 publications

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“…The effect of propantheline on phenolsulfonphthalein absorption is very similar to that on riboflavin absorption (2). Pretreatment with the anticholinergic agent delayed the absorption of both substances but increased appreciably the total amount absorbed.…”

Section: Discussionsupporting

confidence: 52%

“…During the past few decades, numerous observations have confirmed that, in addition to their classic hormonal functions as regulators of reproduction and general metabolism, steroids also play a decisive role in determining the resistance of the body against the most varied types of injury (2). These adaptive steroids can be classified according to their mechanism of action into two main groups: (a) "syntoxic" steroids, which improve host-tissue tolerance by permitting coexistence with the substrate (e.g., by suppressing nonspecific inflammatory or allergic reactions against it); and (b) "catatoxic" steroids, which enhance the detoxication of endogenous and exogenous toxicants oiu induction, activation, decreased degradation of drugmetabolizing enzymes, and/or accelerated substrate elimination from the body.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Vehicle Viscosity and an Anticholinergic Agent on Bioavailability of a Poorly Absorbed Drug (Phenolsulfonphthalein) in Man

Ashley

Levy²

1973

Journal of Pharmaceutical Sciences

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Effect of Vehicle Viscosity and an Anticholinergic Agent on Bioavailability of a Poorly Absorbed Drug (Phenolsulfonphthalein) in Man

Ashley

Levy²

1973

Journal of Pharmaceutical Sciences

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“…Changes in the rate of absorption of paracetamol (Nimmo, Heading, Tothill & Prescott, 1973), digoxin (Manninen, Melin, Apajalhati & Karesoja, 1973), ampicillin and tetracycline (Gothoni, Pentikainen, Vapaatalo, Hackman & Af Bjorkstein, 1972) and riboflavin (Levy, Gibaldi & Procknal, 1972) have also followed concurrent oral administration of metoclopramide.…”

Section: Effect Of Metoclopramidementioning

confidence: 99%

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

Morris

Parsons

Trounce

et al. 1976

Brit J Clinical Pharma

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I The concurrent administration of levodopa with a decarboxylase inhibitor produced a plasma concentration/time curve comparable with 1/4 to 1/5 of the dose of levodopa given alone. 2 There was no evidence to suggest that the decarboxylase inhibitor slowed the rate of elimination of levodopa from plasma. 3 Metoclopramide (Maxolon) increased the rate of levodopa absorption. Higher plasma concentrations of levodopa during the first 2 h after dosing were followed by lower plasma concentrations during the third and fourth hours. The amount of levodopa absorbed after Larodopa as indicated by the AUC was not altered by adding metoclopramide. 4 None of the current preparations of levodopa produced sustained plasma concentrations. 5In vitro testing confirmed that Brocadopa Temtabs tablets disintegrate and dissolve slowly. In vivo, Brocadopa Temtabs behaved as a slow release preparation but it did not produce sustained plasma concentrations of levodopa.

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“…Numerous studies have shown how pharmacological alteration of gastric emptying time alters the rate of drug absorption. Propantheline delays the absorption of riboflavin (Levy, Gibaldi & Procknal, 1972), digoxin (Mannienen, Apajalahati, Melin & Karejosa, 1973) and paracetamol (Gothoni, Pentikainen, Vapaatalo, Hackman & Af Bjorksten, 1972). Atropine delays the absorption of orally administered lignocaine 62 (Adjepon-Yamoah, Scott & Prescott, 1973) and drugs with atropine-like activity can also show this effect.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Thiethylperazine on the Absorption of Effervescent Aspirin in Migraine

Wainscott

Kaspi

1976

Brit J Clinical Pharma

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I The absorption of effervescent aspirin was studied in three groups of patients during attacks of migraine. The first group received intramuscular thiethylperazine 10 min before effervescent aspirin; the second group received intramuscular metoclopramide 10 min before effervescent aspirin; and the third group received effervescent aspirin alone. 2 Where possible each patient was retested when headache-free but under conditions which were otherwise as similar as possible to those during the acute attack. 3 Intramuscular metoclopramide corrected the impairment of drug absorption that occurred during a migraine attack, whereas thiethylperazine did not. 4 In the group of patients treated with thiethylperazine and aspirin, the impairment of absorption did not correlate with the duration of the symptoms, nor with the severity of the headache and nausea. 5 Patients treated with thiethylperazine and aspirin tended to take longer to recover than those patients treated with metoclopramide and aspirin. However, in the thiethylperazine treated group, the time to recover did not correlate with the salicylate level achieved.

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Effect of an Anticholinergic Agent on Riboflavin Absorption in Man

Cited by 46 publications

References 9 publications

Effect of Vehicle Viscosity and an Anticholinergic Agent on Bioavailability of a Poorly Absorbed Drug (Phenolsulfonphthalein) in Man

Effect of Vehicle Viscosity and an Anticholinergic Agent on Bioavailability of a Poorly Absorbed Drug (Phenolsulfonphthalein) in Man

Plasma Dopa Concentrations After Different Preparations of Levodopa in Normal Subjects

The Influence of Thiethylperazine on the Absorption of Effervescent Aspirin in Migraine

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