Effect of an Antenatal Lifestyle Intervention on Dietary Inflammatory Index and Its Associations with Maternal and Fetal Outcomes: A Secondary Analysis of the PEARS Trial

Killeen, Sarah Louise; Phillips, Catherine M.; Delahunt, Anna; Yelverton, Cara A.; Shivappa, Nitin; Hébert, James R.; Kennelly, Maria A.; Cronin, Martina; Mehegan, John; McAuliffe, F

doi:10.3390/nu13082798

Cited by 7 publications

(13 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we did not find differences between neonatal LDL‐cholesterol and the degree of adherence to the MD diet during gestation. In agreement with our results, Killeen et al (2021) found no associations between the maternal inflammatory potential of the diet and triglycerides, HDL‐C, LDL‐C, total cholesterol and glucose in the cord blood. Furthermore, a maternal diet that promoted fish, low‐fat meats and dairy products, oils, whole grains, fruits, vegetables, and legumes decreased maternal cholesterol concentrations, but not cord and neonatal lipids or inflammatory markers (Khoury et al, 2005, 2007), which is in agreement with our findings.…”

Section: Discussionsupporting

confidence: 93%

“…Our findings of an association between MD adherence and maternal cardiometabolic markers throughout gestation were generally consistent with results from other studies (Asemi et al, 2013; Khoury et al, 2005; Martin et al, 2016). Previous randomized controlled trials (Asemi et al, 2013; Khoury et al, 2005; Killeen et al, 2021) and observational studies (Eshriqui et al, 2020; Martin et al, 2016) found an association between healthier maternal dietary patterns and lower total cholesterol, higher HDL‐C, lower LDL‐C, LDL‐C/HDL‐C ratio and triglycerides. Regarding MD adherence, pregnant women in the second trimester of pregnancy (22–26th g.w.)…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Association of Mediterranean diet adherence during pregnancy with maternal and neonatal lipid, glycemic and inflammatory markers: The GESTAFIT project

Flor‐Alemany

Acosta‐Manzano

Migueles

et al. 2022

Maternal & Child Nutrition

View full text Add to dashboard Cite

To examine the association of Mediterranean diet (MD) adherence during pregnancy with maternal and neonatal lipid, glycemic, and inflammatory markers. This study included 152 women from the GESTAFIT trial and a subsample of 35 newborns. The Mediterranean Diet Score, derived from food frequency questionnaires, was employed to assess MD adherence. Total cholesterol, high-density lipoproteincholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, and glucose were assessed in the mother (at the 16th and 34th gestational weeks [g.w.]) and in cord arterial and venous serum with standard procedures using an autoanalyzer. Pro-inflammatory and anti-inflammatory cytokines (interleukin [IL]−6, IL-8, IL-10, IL-1beta, interferon gamma, and tumour necrosis factor alpha [TNF-α]) were measured with Luminex xMAP technology. A greater MD adherence was associated with higher HDL-C and lower LDL-C, LDL-C/HDL-C ratio, triglycerides, triglycerides/HDL-C ratio, and TNF-α in the mother at the 16th and the 34th g.w. (|β|: 0.191-0.388, p < 0.05). A higher intake of whole grain cereals, fruits, vegetables and fish and a lower intake of sweets were associated with higher HDL-C and lower LDL-C, LDL-C/HDL-C ratio, triglycerides, triglycerides/HDL-C ratio, and TNF-α at the 16th and 34th g.w. (|β|: 0.188-0.334, p < 0.05). No

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Association of Mediterranean diet adherence during pregnancy with maternal and neonatal lipid, glycemic and inflammatory markers: The GESTAFIT project

Flor‐Alemany

Acosta‐Manzano

Migueles

et al. 2022

Maternal & Child Nutrition

View full text Add to dashboard Cite

show abstract

“…In our analysis, the maternal E-DII score was positively associated with PW. This is in contrast to findings from secondary analysis of the PEARS RCT ( n = 434) which showed no association between the E-DII score and PW ( 20 ). It should be noted that the PEARS trial comprised women with overweight and obesity, which represent only 24% of the Lifeways subsample, indicating potentially distinct placental inflammatory pathways depending on maternal BMI as previously suggested by Aye et al ( 54 ).…”

Section: Discussioncontrasting

confidence: 99%

“…However, there are no comparative studies conducted thus far which have examined the relationship between maternal dietary scores and placental outcomes in humans. In the one study available, secondary analysis of the PEARS RCT ( n = 434) showed no association between the E-DII score and placental weight ( 20 ).…”

Section: Introductionmentioning

confidence: 96%

Associations between maternal dietary scores during early pregnancy with placental outcomes

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background and aimsIndividual macronutrient and micronutrient effects on placental growth have been widely investigated. However, the influence of overall maternal diet is relatively unknown. Therefore, the aim of this study is to examine associations between a range of maternal dietary scores during early pregnancy with placental outcomes, and to investigate whether there is evidence of sexual dimorphism.MethodsThis analysis of the Lifeways Cross-Generational Cohort includes 276 mother–child pairs. A validated 148-item semi-quantitative food frequency questionnaire assessed maternal diet in early pregnancy. Dietary scores reflecting dietary quality [Healthy Eating Index (HEI-2015), Dietary Approaches to Stop Hypertension (DASH)], dietary inflammatory potential [Dietary Inflammatory Index (DII) and the energy adjusted DII (E-DII)], dietary antioxidant status [Dietary Antioxidant Quality (DAQ)], and glycemic and insulinemic loads/indices (GL/GI, IL/II) were calculated. Linear regression analyses assessed maternal dietary score relationships with untrimmed placental weight (PW) and birth weight:placental weight (BW:PW) ratio.ResultsIn fully adjusted models, maternal E-DII and GI were positively associated, and HEI-2015 and DAQ were negatively associated with PW (B: 12.31, 95% CI: 0.41, 24.20, p = 0.04, B: 4.13, 95% CI: 0.10, 8.17, p = 0.04, B: −2.70, 95% CI: −5.03, −0.35, p = 0.02 and B: −15.03, 95% CI: −28.08, −1.98, p = 0.02, for E-DII, GI, HEI-2015 and DAQ respectively). Maternal DAQ associations with BW:PW ratio were attenuated. When stratified by sex, maternal GI and pregnancy-specific DAQ were associated with PW in female offspring (B: 5.61, 95% CI: 0.27, 10.96, p = 0.04 and B: −15.31, 95% CI: −30.35, −0.27, p = 0.046). Maternal E-DII and HEI-2015 were associated with PW in males (B: 24.31, 95% CI: 5.66, 42.96, p = 0.01 and B: −3.85, 95% CI: −7.47, −0.35, p = 0.03 respectively).ConclusionThe results of this novel investigation suggest that maternal diet may influence placental development. Female fetuses may be more sensitive to increased glucose levels whereas male fetuses may be more susceptible to in-utero stresses that are regulated by inflammatory pathways and overall diet quality. Hence, early pregnancy offers an opportune time for a mother to prioritize dietary changes that focus on reducing inflammatory and glycemic responses.

show abstract

“…kg., Hamburg, Germany). Height was measured to the nearest 0.1 cm using a wall-mounted stadiometer after removal of footwear ( 31 ). Height at baseline and early pregnancy weight were used to calculate maternal BMI (kg/m²).…”

Section: Methodsmentioning

confidence: 99%

Maternal Glycaemic and Insulinemic Status and Newborn DNA Methylation: Findings in Women With Overweight and Obesity

Lecorguillé

McAuliffe

Twomey

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

Context Maternal dysglycaemia and prepregnancy obesity are associated with adverse offspring outcomes. Epigenetic mechanisms such as DNA methylation (DNAm) could contribute. Objective To examine relationships between maternal glycaemia, insulinemic status, and dietary glycemic indices during pregnancy and an antenatal behavioral-lifestyle intervention with newborn DNAm. Methods We investigated 172 women from a randomized controlled trial of a lifestyle intervention in pregnant women who were overweight or obese. Fasting glucose and insulin concentrations and derived indices of insulin resistance (HOMA-IR), β-cell function (HOMA-%B), and insulin sensitivity were determined at baseline (15) and 28 weeks’ gestation. Dietary glycemic load (GL) and index (GI) were calculated from 3-day food diaries. Newborn cord blood DNAm levels of 850K CpG sites were measured using the Illumina Infinium HumanMethylationEPIC array. Associations of each biomarker, dietary index and intervention with DNAm were examined. Results Early pregnancy HOMA-IR and HOMA-%B were associated with lower DNAm at CpG sites cg03158092 and cg05985988, respectively. Early pregnancy insulin sensitivity was associated with higher DNAm at cg04976151. Higher late pregnancy insulin concentrations and GL scores were positively associated with DNAm at CpGs cg12082129 and cg11955198 and changes in maternal GI with lower DNAm at CpG cg03403995 (Bonferroni corrected P < 5.99 × 10−8). These later associations were located at genes previously implicated in growth or regulation of insulin processes. No effects of the intervention on cord blood DNAm were observed. None of our findings were replicated in previous studies. Conclusion Among women who were overweight or obese, maternal pregnancy dietary glycemic indices, glucose, and insulin homeostasis were associated with modest changes in their newborn methylome. Trial registration ISRCTN29316280

show abstract

Effect of an Antenatal Lifestyle Intervention on Dietary Inflammatory Index and Its Associations with Maternal and Fetal Outcomes: A Secondary Analysis of the PEARS Trial

Cited by 7 publications

References 51 publications

Association of Mediterranean diet adherence during pregnancy with maternal and neonatal lipid, glycemic and inflammatory markers: The GESTAFIT project

Association of Mediterranean diet adherence during pregnancy with maternal and neonatal lipid, glycemic and inflammatory markers: The GESTAFIT project

Associations between maternal dietary scores during early pregnancy with placental outcomes

Maternal Glycaemic and Insulinemic Status and Newborn DNA Methylation: Findings in Women With Overweight and Obesity

Contact Info

Product

Resources

About